eukaryotic topoisomerase I

真核細胞ト・イソメラーゼI

関

eukaryotic type I DNA topoisomerase

WordNet

1. the 9th letter of the Roman alphabet (同)i
2. having cells with `good or membrane-bound nuclei (同)eucaryotic

PrepTutorEJDIC

1. 『私は』私が
2. iodineの化学記号

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 強皮症の概要および分類 overview and classification of scleroderma disorders
• 2. 乳癌におけるHER2と治療の効果予測 her2 and predicting response to therapy in breast cancer
• 3. 急性骨髄性白血病における細胞遺伝学 cytogenetics in acute myeloid leukemia
• 4. 全身性硬化症（強皮症）の危険因子および考えられる原因 risk factors for and possible causes of systemic sclerosis scleroderma
• 5. 消失性白質疾患（Vanishing white matter disease） vanishing white matter disease

English Journal

• Endophytic fungi from Miquelia dentata Bedd., produce the anti-cancer alkaloid, camptothecine.

• Shweta S, Gurumurthy BR, Ravikanth G, Ramanan US, Shivanna MB.SourceSchool of Ecology and Conservation and Department of Crop Physiology, University of Agricultural Sciences, GKVK, Bangalore, India.
• Phytomedicine : international journal of phytotherapy and phytopharmacology.Phytomedicine.2013 Feb 15;20(3-4):337-42. doi: 10.1016/j.phymed.2012.11.015. Epub 2012 Dec 27.
• Camptothecine (Campothecin, CPT), a quinoline alkaloid, is a potent inhibitor of eukaryotic topoisomerase I. Several semi-synthetic derivatives of CPT are in clinical use against ovarian, small lung and refractory ovarian cancers. While CPT is produced by several plant species belonging to the Aster
• PMID 23273751

• Interaction between natural compounds and human topoisomerase I.

• Castelli S, Coletta A, D'Annessa I, Fiorani P, Tesauro C, Desideri A.SourceDepartment of Biology, University of Rome Tor Vergata, Via Della Ricerca Scientifica, I-00133 Rome, Italy.
• Biological chemistry.Biol Chem.2012 Nov;393(11):1327-40. doi: 10.1515/hsz-2012-0240.
• Eukaryotic topoisomerase I (Top1) is a monomeric enzyme that catalyzes the relaxation of supercoiled DNA during important processes including DNA replication, transcription, recombination and chromosome condensation. Human Top1 I is of significant medical interest since it is the unique cellular tar
• PMID 23109546

• Two- and three-dimensional live cell imaging of DNA damage response proteins.

• Beckta JM, Henderson SC, Valerie K.SourceDepartment of Radiation Oncology, Virginia Commonwealth University, USA.
• Journal of visualized experiments : JoVE.J Vis Exp.2012 Sep 28;(67). pii: 4251. doi: 10.3791/4251.
• Double-strand breaks (DSBs) are the most deleterious DNA lesions a cell can encounter. If left unrepaired, DSBs harbor great potential to generate mutations and chromosomal aberrations. To prevent this trauma from catalyzing genomic instability, it is crucial for cells to detect DSBs, activate the D
• PMID 23052275

Japanese Journal

• 4′,6-Dihydroxy-4-methoxyisoaurone Inhibits the HIF-1α Pathway Through Inhibition of Akt/mTOR/p70S6K/4E-BP1 Phosphorylation

• Mi Chunliu,Ma Juan,Shi Hui,Li Jing,Wang Fei,Lee Jung Joon,Jin Xuejun
• Journal of Pharmacological Sciences 125(2), 193-201, 2014
• … This compound markedly decreased the hypoxia-induced accumulation of HIF-1α protein dose-dependently, whereas it did not affect the expressions of HIF-1β and topoisomerase-I (Topo-I). …
• NAID 130004438624

• Inhibitory effect of coenzyme Q_1 on eukaryotic DNA polymerase γ and DNA topoisomerase II activities on the growth of a human cancer cell line

• YONEZAWA Yuko,KURIYAMA Isoko,FUKUOH Atsushi,MUTA Tsuyoshi,KANG Dongchon,TAKEMURA Masaharu,KATO Ikuo,YOSHIDA Hiromi,MIZUSHINA Yoshiyuki
• Cancer science 97(8), 716-723, 2006-08-10
• NAID 10018768119

• Inhibition of Topoisomerase II α Subunit De Novo Synthesis by Specific Antisense Oligonucleotides Suppresses Human Gliomo T98G Cell Growth

• 申 正樹,KIMURA Shoji,NAGAO Seigo
• Neurologia medico-chirurgica 39(3), 199-205, 1999-03-15
• 本実験では様々な抗ガン剤の標的酵素とされるトボイソメラーゼIIに対するアンチセンスオリゴヌクレオタイドを用いて、T98Gヒトグリオーマ培養細胞の増殖を抑制し、その際トボイソメラーゼII酵素活性は低下しトポイソメラーゼI酵素活性は増強される傾向にあることを確かめた。このことよりトポイソメラーゼIIはT98Gヒトグリオーマ細胞が順調に増殖するためには不可欠な酵素の一つで、これを抑制することで細胞増殖を …
• NAID 110002279734

Related Links

• Polynucleotide Ligase Activity of Eukaryotic Topoisomerase I

Introduction of a single ribonucleoside immediately 5′ of the scissile phosphate of a duplex DNA substrate converts eukaryotic topoisomerase I into an endorib ... Figure 2. Topoisomerase Cleavage at a Single Ribonucleoside in ...

• DNA topoisomerase V is a relative of eukaryotic topoisomerase ...

1. Gellert, M. A. Rev. Biochem. 50, 879−910 (1981). | Article | ISI | ChemPort | 2. Wang, J. C. A. Rev. Biochem. 54, 665−697 (1985). | Article | ISI | ChemPort | 3. Maxwell, A. & Gellert, M. Adv. Protein Chem. 38, 68−107 ...

---

★リンクテーブル★

リンク元	「真核細胞トポイソメラーゼI」「eukaryotic type I DNA topoisomerase」
拡張検索	「eukaryotic topoisomerase II」
関連記事	「I」「topoisomerase I」「eukaryotic」「Id」

「真核細胞トポイソメラーゼI」

　　[★]

英

eukaryotic topoisomerase I

関

真核生物ト・イソメラーゼI

「eukaryotic type I DNA topoisomerase」

　　[★]

• 真核生物ト・イソメラーゼI

関

eukaryotic topoisomerase I

「eukaryotic topoisomerase II」

　　[★]

真核細胞ト・イソメラーゼII

「I」

　　[★]

• イソロイシン isoleucine
• イノシン inosine
• 阻害剤 inhibitor
• iodine
• ヨード iodide
• I因子 factor I

　 　 　

「topoisomerase I」

　　[★]

ト・イソメラーゼI

関

DNA topoisomerase、DNA topoisomerase I、type I DNA topoisomerase

「eukaryotic」

　　[★]

• 真核生物の

関

eucaryote、eukaryote、eukaryotic organism

　

「Id」

　　[★]

• イディオタイプ idiotype idiotypic
• inhibitor of DNA binding