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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/23 10:57:10」(JST)

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Etretinate (trade name Tegison) is a medication developed by Hoffmann–La Roche that was approved by the FDA in 1986 to treat severe psoriasis. It was subsequently removed from the United States market in 1998 and the Canadian market in 1996, due to the high risk of birth defects.

Properties[edit]

Etretinate has a low therapeutic index and a long elimination half-life (t_1/2) of 120 days, which make dosing difficult.

Etretinate is an aromatic retinoid, and therefore highly lipophilic. It is stored and released from adipose tissue, so its effects can continue long after dosage stops. It is detectable in the plasma for up to three years following therapy.

Etretinate has been replaced by acitretin, a safer metabolite of etretinate.

Precautions[edit]

Etretinate is a teratogen, and may cause birth defects long after use. Therefore, birth control is advised during therapy, and for at least three years after therapy has stopped.
Etretinate should be avoided in children, as it may interfere with bone growth.

If a patient has ever taken etretinate, he or she is not eligible to donate blood, due to the risk of birth defects.^[1]

Side effects[edit]

Hepatitis
Pseudotumor cerebri
Diffuse idiopathic skeletal Hyperostosis

References[edit]

^ UK Blood Transfusion and Tissue Transplantation Services[1]

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UpToDate Contents

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1. 掌蹠膿疱症：治療 palmoplantar pustulosis treatment
2. 膿疱性乾癬：マネージメント pustular psoriasis management
3. 難治性円板状ループスおよび亜急性皮膚ループスのマネージメント management of refractory discoid lupus and subacute cutaneous lupus
4. 供血者スクリーニング：病歴 blood donor screening medical history
5. 妊娠時の乾癬のマネージメント management of psoriasis in pregnancy

English Journal

Clinical and laboratory features in acute generalized pustular psoriasis: a retrospective study of 34 patients.

Borges-Costa J, Silva R, Goncalves L, Filipe P, Soares de Almeida L, Marques Gomes M.SourceClinical University of Dermatology of Lisbon, Portugal. joaobc77@hotmail.com
American journal of clinical dermatology.Am J Clin Dermatol.2011 Aug 1;12(4):271-6. doi: 10.2165/11586900-000000000-00000.
BACKGROUND: Acute generalized pustular psoriasis (AGPP) is a rare variant of psoriasis that can be lethal without proper treatment. It can be caused by the withdrawal of corticosteroids and, among its extra-cutaneous manifestations, liver abnormalities are frequently under-reported or attributed to
PMID 21495733

Relative developmental toxicity potencies of retinoids in the embryonic stem cell test compared with their relative potencies in in vivo and two other in vitro assays for developmental toxicity.

Louisse J, Gonen S, Rietjens IM, Verwei M.SourceDivision of Toxicology, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands. jochem.louisse@wur.nl
Toxicology letters.Toxicol Lett.2011 May 30;203(1):1-8. Epub 2011 Feb 26.
The present study determines the relative developmental toxicity potencies of retinoids in the embryonic stem (ES)-D3 cell differentiation assay of the embryonic stem cell test, and compares the outcomes with their relative potencies in in vivo and two other in vitro assays for developmental toxicit
PMID 21362465

Japanese Journal

エトレチナートが著効したグルカゴノーマを伴った壊死性遊走性紅斑の1例 (特集紅斑症)

森下恵理,根岸晶,相原道子 [他]
皮膚科の臨床 53(6), 827-831, 2011-06
NAID 40018873457

尋常性乾癬患者に生じた股関節症に対して人工股関節全置換術を施行した1例

峯岸洋次郎,内山勝文,福島健介,高平尚伸,南谷淳,糸満盛憲
関東整形災害外科学会雑誌 41(4), 171-176, 2010-08-01
NAID 10026502345

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リンク元	「エトレチナート」「エトレチネート」

「エトレチナート」

Etretinate
Systematic (IUPAC) name
	ethyl 9-(4-methoxy-2,3,6-trimethyl-phenyl)- 3,7-dimethyl-nona- 2,4,6,8-tetraenoate
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601010
Legal status	?
Routes	Oral
Pharmacokinetic data
Half-life	120 days
Identifiers
CAS number	54350-48-0
ATC code	D05BB01
PubChem	CID 5282375
DrugBank	DB00926
ChemSpider	4445538
UNII	65M2UDR9AG
KEGG	D00316
ChEBI	CHEBI:4913
ChEMBL	CHEMBL464
Chemical data
Formula	C23H30O3
Mol. mass	354.483 g/mol
	SMILES O=C(OCC)\C=C(\C=C\C=C(\C=C\c1c(cc(OC)c(c1C)C)C)C)C;
	InChI InChI=1S/C23H30O3/c1-8-26-23(24)14-17(3)11-9-10-16(2)12-13-21-18(4)15-22(25-7)20(6)19(21)5/h9-15H,8H2,1-7H3/b11-9+,13-12+,16-10+,17-14+ ; Key:HQMNCQVAMBCHCO-DJRRULDNSA-N ;
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