English Journal

Exploring the binding affinities of p300 enzyme activators CTPB and CTB using docking method.

Devipriya B, Parameswari AR, Rajalakshmi G, Palvannan T, Kumaradhas P.SourceLaboratory of Biocrystallography and Computational Molecular Biology, Periyar University, Salem 636011, India.
Indian journal of biochemistry & biophysics.Indian J Biochem Biophys.2010 Dec;47(6):364-9.
CREB binding protein (CBP) and E1A binding protein p300, also known as p300 are functionally related transcriptional co-activators (CoAs) and histone acetyltransferases (HATs). Some small molecules, which target HATs can activate or inhibit the p300 enzyme potently. Here, we report the binding affin
PMID 21355420

Herringbone array of hydrogen-bonded ribbons in 2-ethoxybenzamide from high-resolution X-ray powder diffraction.

Pagola S, Stephens PW.SourceDepartment of Applied Science, College of William and Mary, Williamsburg, VA 23187, USA. spagol@wm.edu
Acta crystallographica. Section C, Crystal structure communications.Acta Crystallogr C.2009 Nov;65(Pt 11):o583-6. doi: 10.1107/S0108270109040803. Epub 2009 Oct 17.
In 2-ethoxybenzamide, C(9)H(11)NO(2), the amide substituents are linked into centrosymmetric head-to-head hydrogen-bonded dimers. Additional hydrogen bonds between adjacent dimers give rise to ribbon-like packing motifs, which extend along the c axis and possess a third dimension caused by twisting
PMID 19893241

Intrinsically fluorescent carbon nanospheres as a nuclear targeting vector: delivery of membrane-impermeable molecule to modulate gene expression in vivo.

Selvi BR, Jagadeesan D, Suma BS, Nagashankar G, Arif M, Balasubramanyam K, Eswaramoorthy M, Kundu TK.SourceTranscription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore-560 064, India.
Nano letters.Nano Lett.2008 Oct;8(10):3182-8. doi: 10.1021/nl801503m. Epub 2008 Sep 19.
In this report, we demonstrate glucose-derived carbon nanospheres to be an emerging class of intracellular carriers. The surfaces of these spheres are highly functionalized and do not need any further modification. Besides, the intrinsic fluorescence property of carbon nanospheres helps in tracking
PMID 18800851

Japanese Journal

Grinding-Induced Equimolar Complex Formation between Thiourea and Ethenzamide

Moribe Kunikazu,Tsuchiya Masami,Tozuka Yuichi [他],YAMAGUCHI Kentaro,OGUCHI Toshio,YAMAMOTO Keiji
Chemical & pharmaceutical bulletin 52(5), 524-529, 2004-05-01
… The complex formation was not observed in the cases where benzamide, salicylamide or 3-ethoxybenzamide was co-ground with thiourea. …
NAID 110003615607

Development of Potent Serotonin-3 (5-HT_3) Receptor Antagonists. I. Structure-Activity Relationships of 2-Alkoxy-4-amino-5-chlorobenzamide Derivatives

原田博史,森江俊哉,広川美視,吉田直之,賀登志朗
Chemical & pharmaceutical bulletin 43(8), 1364-1378, 1995-08-15
… In particular, 4-amino-5-chloro-N-(1,4-dimethylhexahydro-1H-1,4-diazepin-6-yl)-2-ethoxybenzamide (96) and the 1-benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 103 showed potent 5-HT_3 receptor antagonistic activity without 5-HT_4 receptor binding affinity. …
NAID 110003631667

Synthesis and Structure-Activity Relationships of 4-Amino-5-chloro-2-ethoxybenzamides with Six- and Seven-Membered Heteroalicycles as Potential Gastroprokinetic Agents

森江俊哉,賀登志朗,原田博史,吉田直之,藤原厳,松本純一
Chemical & pharmaceutical bulletin 43(7), 1137-1147, 1995-07-15
… Compounds 3b-e, derived by replacement of the morpholine oxygen of 4-amino-N-[(4-benzyl-2-morpholinyl)methyl]-5-chloro-2-ethoxybenzamide (3a) with other atoms (sulfur, nitrogen and carbon), generally exhibited a potent gastric emptying activity. …
NAID 110003631623

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