English Journal

Mechanochemistry applied to reformulation and scale-up production of Ethionamide: Salt selection and solubility enhancement.

de Melo CC1, da Silva CC2, Pereira CC3, Rosa PC3, Ellena J4.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2016 Jan 1;81:149-56. doi: 10.1016/j.ejps.2015.10.007. Epub 2015 Oct 22.
Ethionamide (ETH), a Biopharmaceutics Classification System class II drug, is a second-line drug manufactured as an oral dosage form by Pfizer to treat tuberculosis. Since its discovery in 1956, only one reformulation was proposed in 2005 as part of the efforts to improve its solubility. Due to the
PMID 26472469

Genotypic Analysis of Genes Associated with Independent Resistance and Cross-Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis Clinical Isolates.

Rueda J1, Realpe T2, Mejia GI3, Zapata E3, Rozo JC4, Ferro BE5, Robledo J2.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2015 Dec;59(12):7805-10. doi: 10.1128/AAC.01028-15. Epub 2015 Sep 14.
Ethionamide (ETH) is an antibiotic used for the treatment of multidrug-resistant (MDR) tuberculosis (TB) (MDR-TB), and its use may be limited with the emergence of resistance in the Mycobacterium tuberculosis population. ETH resistance in M. tuberculosis is phenomenon independent or cross related wh
PMID 26369965

Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase.

Choi J1, Park SJ2, Jee JG3.
European journal of medicinal chemistry.Eur J Med Chem.2015 Dec 1;106:157-66. doi: 10.1016/j.ejmech.2015.10.033. Epub 2015 Oct 19.
Tyrosinase catalyzes two distinct sequential reactions in melanin biosynthesis: the hydroxylation of tyrosine to DOPA followed by the oxidation of DOPA to dopaquinone. The central roles of melanin in living species have motivated researchers to maintain constant efforts to discover new agents that m
PMID 26544630