The interaction of a series of benzothiadiazides with human serum albumin (HSA) was investigated by equilibrium dialysis (ED) and spectroscopic methods including circular dichroism (CD). The primary binding site of benzothiadiazides was designated site II, the diazepam site on the HSA molecule, as i
Epimerization and racemization of some chiral drugs in the presence of human serum albumin.
Aso Y1, Yoshioka S, Takeda Y.
Chemical & pharmaceutical bulletin.Chem Pharm Bull (Tokyo).1990 Jan;38(1):180-4.
Epimerization and racemization of carbenicillin, ethiazide, etoposide and oxazepam acetate were examined kinetically in the presence of human serum albumin (HSA). The concentration of both optical isomers of each drug was determined by stereospecific high-performance liquid chromatography. The appar
Epimerization and racemization of some chiral drugs in the presence of cyclodextrin and liposomes.
Aso Y, Yoshioka S, Takeda Y.
Chemical & pharmaceutical bulletin.Chem Pharm Bull (Tokyo).1989 Oct;37(10):2786-9.
The effects of alpha-, beta-, gamma- and dimethyl-beta-cyclodextrins (alpha-, beta-, gamma- and DM-beta-CyDs) and liposomes on epimerization or racemization of etoposide, ethiazide and carbenicillin were examined kinetically. alpha- and beta-CyDs accelerated both epimerization and hydrolysis of carb
Ethiazide の長期連続投与による毒性について Chronic Toxicity Test of Ethiazide 久田 四郎 [他] HISADA SHIRO 名古屋市立大学医学部薬理学教室 Department of Pharmacology, Nagoya City University Medical School 中島 敏夫 ...