estrogen therapy

出典: meddic


Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/12/04 15:55:36」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

英文文献

  • Diacylglycerol kinase α mediates 17-β-estradiol-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell line through the G protein-coupled estrogen receptor GPR30.
  • Filigheddu N, Sampietro S, Chianale F, Porporato PE, Gaggianesi M, Gregnanin I, Rainero E, Ferrara M, Perego B, Riboni F, Baldanzi G, Graziani A, Surico N.AbstractIncreased levels of endogenous and/or exogenous estrogens are one of the well known risk factors of endometrial cancer. Diacylglycerol kinases (DGKs) are a family of enzymes which phosphorylate diacylglycerol (DAG) to produce phosphatidic acid (PA), thus turning off and on DAG-mediated and PA-mediated signaling pathways, respectively. DGK α activity is stimulated by growth factors and oncogenes and is required for chemotactic, proliferative, and angiogenic signaling in vitro. Herein, using either specific siRNAs or the pharmacological inhibitor R59949, we demonstrate that DGK α activity is required for 17-β-estradiol (E2)-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell line. Impairment of DGK α activity also influences basal cell proliferation and growth in soft agar of Hec-1A, while it has no effects on basal cell motility. Moreover, we show that DGK α activity induced by E2, as well as its observed effects, are mediated by the G protein-coupled estrogen receptor GPR30 (GPER). These findings suggest that DGK α may be a potential target in endometrial cancer therapy.
  • Cellular signalling.Cell Signal.2011 Dec;23(12):1988-96. Epub 2011 Jul 22.
  • Increased levels of endogenous and/or exogenous estrogens are one of the well known risk factors of endometrial cancer. Diacylglycerol kinases (DGKs) are a family of enzymes which phosphorylate diacylglycerol (DAG) to produce phosphatidic acid (PA), thus turning off and on DAG-mediated and PA-mediat
  • PMID 21802511

和文文献

  • <Case Reports>A case of apocrine ad enocarcinoma in the right axilla
  • Yoshida Masuki,Kawara Shigeru,Kawada Akira
  • Acta Medica Kinki University 36(1), 29-31, 2011-6
  • … Immunohistochemically, the tumor cells were negative for both estrogen and progesterone receptors and positive for CEA and GCDFP-15. … Postoperative radiation therapy or chemotherapy was not administered, and she has been free from metastasis for 4 years since the operation. …
  • NAID 120003291654

関連リンク

1 day ago ... Hormone therapy (HT, HRT, ERT, ET), can ease the symptoms of menopause and protect against osteoporosis.

関連画像


押しても画像が表示されない場合はサーバが混雑しています。2週間ほどあけて、再度押下してください。


★リンクテーブル★
リンク元エストロゲン療法
拡張検索antiestrogen therapy
関連記事therapy」「estrogen

エストロゲン療法」

  [★]

estrogen therapy


antiestrogen therapy」

  [★]

抗エストロゲン療法


therapy」

  [★]

  • n.
carecurecuringpracticepsychotherapyregimenremediationremedytherapeutictreattreatmenttreatment protocol

PrepTutorEJDIC   license prepejdic

「(病気の)治療,療法 / =psychotherapy」

WordNet   license wordnet

「(medicine) the act of caring for someone (as by medication or remedial training etc.); "the quarterback is undergoing treatment for a knee injury"; "he tried every treatment the doctors suggested"; "heat therapy gave the best relief"」


estrogen」

  [★] エストロゲン

WordNet   license wordnet

「a general term for female steroid sex hormones that are secreted by the ovary and responsible for typical female sexual characteristics」
oestrogen

PrepTutorEJDIC   license prepejdic

「エストロゲン(動物の雌を発情させる卵胞ホルモン)(《英》oestrogen)」




★コメント★

[メモ入力エリア]
※コメント5000文字まで
ニックネーム:
コメント:




表示
個人用ツール


  meddic.jp

リンク
連絡