WordNet

the most powerful female hormone that occurs naturally; synthesized and used to treat estrogen deficiency and breast cancer (同)oestradiol
any salt or ester of benzoic acid

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安息香酸の塩またはエステル

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/03 09:37:33」(JST)

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Estradiol benzoate (INN; brand names Agofollin, Diffolisterol, Progynon-B, many others), or oestradiol benzoate (BAN), is a synthetic ester, specifically the 3-benzoyl ester, of the natural estrogen, estradiol.^[1]^[2] It was the first form of estrogen to be marketed, patented by Schering-Kahlbaun in 1936 in an oil preparation for injectable use and introduced later that year as Progynon-B.^[3]^[4] Though it is still in widespread use today, it has been mostly superseded by newer forms of estradiol with improved pharmacokinetics that require less frequent administration such as estradiol cypionate and estradiol valerate.^[5]

A single dose of 2.5 mg estradiol benzoate by intramuscular injection was found to produce plasma estradiol levels of >400 pg/mL, measured 24 hours post-injection, in a group of patients with minimal baseline levels of estradiol (due to GnRH analogue therapy with triptorelin).^[6]

References

^ A. D. Roberts (1991). Dictionary of Steroids: Chemical Data, Structures, and Bibliographies. CRC Press. p. 414. ISBN 978-0-412-27060-4. Retrieved 20 May 2012.
^ Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 406. ISBN 978-3-88763-075-1. Retrieved 20 May 2012.
^ Enrique Raviña; Hugo Kubinyi (16 May 2011). The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs. John Wiley & Sons. p. 175. ISBN 978-3-527-32669-3. Retrieved 20 May 2012.
^ Folley SJ (December 1936). "The effect of oestrogenic hormones on lactation and on the phosphatase of the blood and milk of the lactating cow" (PDF). The Biochemical Journal 30 (12): 2262–72. PMC 1263335. PMID 16746289.
^ Oriowo MA, Landgren BM, Stenström B, Diczfalusy E (April 1980). "A comparison of the pharmacokinetic properties of three estradiol esters". Contraception 21 (4): 415–24. doi:10.1016/s0010-7824(80)80018-7. PMID 7389356.
^ Vizziello G, D'Amato G, Trentadue R, Fanizza G (1993). "[Estradiol benzoate test in the study of pituitary block induced by triptorelin]". Minerva Ginecol (in Italian) 45 (4): 185–9. PMID 8506068.

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1. エストロゲン・プロゲスチン避妊剤の使用に関する概要 overview of the use of estrogen progestin contraceptives
2. 閉経期のホルモン療法で用いる製剤 preparations for menopausal hormone therapy
3. 緊急避妊剤 emergency contraception
4. 経皮吸収避妊パッチ transdermal contraceptive patch
5. 月経抑制のためのホルモン避妊法 hormonal contraception for suppression of menstruation

English Journal

Effects of preovulatory estradiol on embryo survival and pregnancy establishment in beef cows.

Madsen CA1, Perry GA2, Mogck CL3, Daly RF4, MacNeil MD5, Geary TW6.
Animal reproduction science.Anim Reprod Sci.2015 Jul;158:96-103. doi: 10.1016/j.anireprosci.2015.05.006. Epub 2015 May 16.
The role of preovulatory estradiol on post-fertilization embryo survival and pregnancy establishment has not been well characterized in beef cows. We hypothesized that preovulatory estradiol is important for embryo survival and pregnancy establishment in beef cows. Twenty-four ovariectomized multipa
PMID 26022231

The effects of prenatal PCBs on adult social behavior in rats.

Reilly MP1, Weeks CD2, Topper VY3, Thompson LM1, Crews D4, Gore AC5.
Hormones and behavior.Horm Behav.2015 Jun 17. pii: S0018-506X(15)00107-5. doi: 10.1016/j.yhbeh.2015.06.002. [Epub ahead of print]
Endocrine disrupting chemical (EDC) exposures during critical periods of development may influence neuronal development and the manifestation of sexually dimorphic sociability and social novelty behaviors in adulthood. In this study, we assessed the effects of gestational exposure to PCBs on the soc
PMID 26093262

Aromatase expression is linked to estrogenic sensitivity of periurethral muscles in female rabbits.

de Los Ángeles Carrasco-Ruiz M1,2, García-Villamar V1,3, López-García K1,4, Sánchez-García O1,2, Pacheco P5,6, Cuevas E1, Martínez-Gómez M1,5, Castelán F1.
Cell biochemistry and function.Cell Biochem Funct.2015 Jun;33(4):188-95. doi: 10.1002/cbf.3102. Epub 2015 Apr 7.
Beyond its role in the conversion of androgens to estrogens, the expression of aromatase could influence on the estrogenic signalling in targeted tissues. Considering the well-defined biochemical and physiological differences between the pubococcygeus (Pcm) and bulbospongiosus (Bsm) muscles in femal
PMID 25850953

Japanese Journal

An in vivo mouse model of primary dysmenorrhea

, , ,
Experimental Animals advpub(0), 2015
… Methods: After pretreated with estradiol benzoate (1 mg/kg/d) intraperitoneally (i.p.) for 3 consecutive days, non-pregnant female Imprinting Control Region mice (6–8 weeks old) was injected with 0.4 U of oxytocin to induce the stretching or writhing response which was recorded for a time period of 30 min. During the writhing period, the uterine artery blood flow alterations were examined by Doppler ultrasound detection. …
NAID 130005066236

発情徴候が認められない乳牛におけるPGF₂α製剤と安息香酸エストラジオール製剤との同時併用投与の人工授精率及び繁殖率向上効果 (日本獣医師会雑誌(日獣会誌)) -- (産業動物臨床・家畜衛生関連部門)

山口佳男,下田崇,三好憲一 [他]
日本獣医師会雑誌 = Journal of the Japan Veterinary Medical Association 67(4), 255-258, 2014-04
NAID 40020063907

発情徴候が認められない乳牛におけるPGF2α製剤と安息香酸エストラジオール製剤との同時併用投与の人工授精率及び繁殖率向上効果

山口佳男,下田崇,三好憲一,白砂孔明,宮本明夫
日本獣医師会雑誌 67(4), 255-258, 2014
発情及び発情徴候がない分娩後未授精及び人工授精後不受胎と診断された乳牛にPGF2α15mgと安息香酸エストラジオール（E2B）4mgを同時投与し，授精率と受胎率を調べた．投与後3日以内に授精した牛は79.1％で，受胎率は38.7％であった．血中プロジェステロン濃度が，1ng/ml以上を示す機能性黄体群では授精率100％，受胎率35.3％で，1ng/ml未満では授精率55.6％，受胎率30.0％であ …
NAID 130004888062

Related Pictures

★リンクテーブル★

リンク元	「エストラジオール」「EB」「17 beta-estradiol」「estradiol-17beta」
関連記事	「estradiol」

「エストラジオール」

Estradiol benzoate
Systematic (IUPAC) name
	(17β)-17-hydroxyestra-1,3,5(10)-trien-3-yl benzoate
Clinical data
Legal status	℞ (Prescription only);
Routes of; administration	IM
Identifiers
CAS Number	50-50-0
ATC code	None
PubChem	CID: 222757
ChemSpider	193412
ChEBI	CHEBI:77006
Synonyms	17β-Estradiol-3-benzoate
Chemical data
Formula	C25H28O3
Molecular mass	376.488 g/mol
	SMILES O=C(Oc1cc3c(cc1)[C@H]2CC[C@@]4([C@@H](O)CC[C@H]4[C@@H]2CC3)C)c5ccccc5 ;
	InChI InChI=1S/C25H28O3/c1-25-14-13-20-19-10-8-18(28-24(27)16-5-3-2-4-6-16)15-17(19)7-9-21(20)22(25)11-12-23(25)26/h2-6,8,10,15,20-23,26H,7,9,11-14H2,1H3/t20-,21-,22+,23+,25+/m1/s1 ; Key:UYIFTLBWAOGQBI-BZDYCCQFSA-N ;