紅色肥厚症
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/25 10:58:34」(JST)
[Wiki en表示]
| Erythroplakia |
| Classification and external resources |
| ICD-10 |
K13.2 |
| ICD-9 |
528.79 |
| DiseasesDB |
30783 |
Erythroplakia (also known as "Erythroplasia"[1]:734) is a flat red patch or lesion in the mouth[2] that cannot be attributed to any other pathology.[3]:805
A similar term is "erythroplasia", which has a papular appearance.[4]
Contents
- 1 Diagnosis and associated conditions
- 2 Causes
- 3 Presentation
- 4 Treatment
- 5 See also
- 6 References
Diagnosis and associated conditions[edit]
There are many other conditions that are similar in appearance and must be ruled out before a diagnosis of erythroplakia is made. Sometimes, a diagnosis is delayed for up to two weeks in order to see if the lesion spontaneously regresses on its own or if another cause can be found. Erythroplakia frequently is associated with dysplasia, and is thus a precancerous lesion.
Causes[edit]
Erythroplakia has an unknown cause but researchers presume it to be similar to the cause of squamous cell carcinoma. Carcinoma is found in almost 40% of erythroplakia.[5] It is mostly found in elderly men around the ages of 65 - 74. It is commonly associated with smoking.
Alcohol and tobacco use have been described as risk factors.[6]
Presentation[edit]
The most common areas in the mouth where erythroplakia is found are the floor of the mouth, the tongue, and the soft palate. It appears as a red macule or plaque with well-demarcated borders. The texture is characterized as soft and velvety. An adjacent area of leukoplakia may be found along with the erythroplakia.
Microscopically, the tissue exhibits severe epithelial dysplasia, carcinoma-in-situ, or invasive squamous cell carcinoma in 90% of cases. There is an absence of keratin production and a reduced number of epithelial cells. Since the underlying vascular structures are less hidden by tissue, erythroplakia appears red when viewed in a clinical setting.
Treatment[edit]
Treatment involves biopsy of the lesion to identify extent of dysplasia. Complete excision of the lesion is sometimes advised depending on the histopathology found in the biopsy. Even in these cases, recurrence of the erythroplakia is common and, thus, long-term monitoring is needed.
See also[edit]
- List of cutaneous conditions
References[edit]
- ^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
- ^ "erythroplakia" at Dorland's Medical Dictionary
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ "erythroplasia" at Dorland's Medical Dictionary
- ^ Ridge JA, Glisson BS, Lango MN, et al. "Head and Neck Tumors" in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer Management: A Multidisciplinary Approach. 11 ed. 2008.
- ^ Hashibe M, Mathew B, Kuruvilla B, et al (July 2000). "Chewing tobacco, alcohol, and the risk of erythroplakia". Cancer Epidemiol. Biomarkers Prev. 9 (7): 639–45. PMID 10919731.
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Oral and maxillofacial pathology (K06, K11–K14, 523, 527–529)
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| Lips |
Cheilitis (Angular · Actinic · Plasma cell) · Herpes labialis · Trumpeter's wart
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| Tongue |
Glossitis (Geographic tongue · Median rhomboid glossitis · Transient lingual papillitis) · Fissured tongue · Black hairy tongue · Caviar tongue · Macroglossia · Hypoglossia · Ankyloglossia · Crenated tongue · Osseous choristoma of the tongue
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| Oral mucosa |
Oral ulceration · Stomatitis (Aphthous · Herpetic · Nicotinic · Denture-related) · Erythroplakia · Leukoplakia · Hairy leukoplakia · Leukoedema · White sponge nevus · Burning mouth syndrome · Fordyce spots · Lichen planus · Morsicatio buccarum · Linea alba · Behçet syndrome · Angina bullosa haemorrhagica · Melanocytic oral lesion · Oral melanosis · Recurrent intraoral herpes simplex infection · Plasmoacanthoma · Oral florid papillomatosis · Oral candidiasis
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Teeth
(pulp, dentin, enamel) |
Dental caries · Dentin hypersensitivity · Pulpitis · Pulpal necrosis · Pulp polyp · Pulp calcification · Fluorosis · Hypodontia · Hyperdontia · Macrodontia · Microdontia · Dilaceration · Taurodontism · Fusion · Gemination · Concrescence · Amelogenesis imperfecta · Dentinogenesis imperfecta · Dentinal dysplasia · Regional odontodysplasia · Attrition · Abrasion · Erosion · Resorption · Premature eruption · Delayed eruption · Impaction · Odontome (Dens in dente) · Odontogenic tumors (Keratocystic odontogenic tumour)
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Periodontium
(gingiva, Periodontal ligament,
cementum, alveolus)
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Gingivitis (Desquamative gingivitis · Plasma cell gingivitis) · Epulis (Pyogenic granuloma) · Gingival overgrowth · Periodontitis · Pericoronitis · Necrotizing periodontal diseases (Acute necrotizing ulcerative gingivitis · Noma) · Periodontal abscess · Hypercementosis · Hypocementosis
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Periapaical, mandibular
and maxillary hard tissues |
Periapical periodontitis · Periapical abscess · Alveolar osteitis · Osteoradionecrosis · Torus palatinus · Torus mandibularis · Cherubism · Paget's disease of bone · Mandibular fracture · Stafne defect · Osteomyelitis of the jaws
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Temporomandibular joints and
muscles of mastication |
Temporomandibular joint dysfunction · Bruxism · Mandibular dislocation
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| Salivary glands |
Sialadenitis (Parotitis) · Sialolithiasis · Mucous cyst of the oral mucosa (Ranula) · Sjögren's syndrome · Sialocele · Benign lymphoepithelial lesion · Necrotizing sialometaplasia · Salivary gland neoplasms (Pleomorphic adenoma)
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| Orofacial soft tissues |
Ludwig's angina · Cutaneous sinus of dental origin · Cystic hygroma · Velopharyngeal inadequacy · Actinomycosis · Orofacial granulomatosis · Melkersson–Rosenthal syndrome · Pyostomatitis vegetans · Oral Crohn's disease · Epulis fissuratum · Perioral dermatitis
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noco/cofa (c)/cogi/tumr, sysi
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UpToDate Contents
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English Journal
- A retrospective analysis of real-life practice of off-label photodynamic therapy using methyl aminolevulinate (MAL-PDT) in 20 Italian dermatology departments. Part 2: oncologic and infectious indications.
- Calzavara-Pinton PG, Rossi MT, Sala R; Italian Group For Photodynamic Therapy.Collaborators (23)Calzavara-Pinton P, Rossi MT, Sala R, Arpaia N, Burtica EC, Amerio P, Virgili A, Rossi R, Buggiani G, Zanca A, Bugatti L, Fai D, Cervadoro E, Cavicchini S, Fantini F, Fabbrocini G, Piaserico S, Cervadoro E, Teoli M, Eibenschutz L, Arcangeli F, Broganelli P, Schena D.
- Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.Photochem Photobiol Sci.2013 Jan;12(1):158-65. doi: 10.1039/c2pp25125f.
- Photodynamic therapy (PDT) with methyl aminolevulinate (MAL) has been suggested as a useful treatment option in a number of skin tumors, other than approved indications, and infections. However, evidence is poor because it is mainly supported by isolated case reports or small case series, often with
- PMID 22949076
- Utility of toluidine blue as a diagnostic adjunct in the detection of potentially malignant disorders of the oral cavity--a clinical and histological assessment.
- Awan Kh, Yang Y, Morgan P, Warnakulasuriya S.SourceOral Medicine and Head & Neck Pathology, Department of Clinical & Diagnostic Sciences, King's College London Dental Institute, London, UK.
- Oral diseases.Oral Dis.2012 Nov;18(8):728-33. doi: 10.1111/j.1601-0825.2012.01935.x. Epub 2012 Apr 24.
- BACKGROUND: The value of chairside adjunctive tests in the detection of oral potentially malignant disorders (OPMDs) remains uncertain.OBJECTIVES: To determine the effectiveness of toluidine blue in detecting leukoplakia and erythroplakia and its accuracy in identifying cases with oral epithel
- PMID 22524200
- Erythroplasia of Queyrat refractory to photodynamic therapy.
- Park JY, Kim SJ, Kim YC.
- Clinical and experimental dermatology.Clin Exp Dermatol.2012 Oct;37(7):795-7. doi: 10.1111/j.1365-2230.2012.04361.x. Epub 2012 Jul 25.
- PMID 22831651
Japanese Journal
- 症例 関節リウマチ患者にQueyrat紅色肥厚症と多発性の日光角化症を併発した1例
- 症例報告 外尿道口に病変を認めたHPV16陽性Queyrat紅色肥厚症
- A case of Erythroplasia of Queyrat
- 千葉 由幸,小川 徹,清水 調
- Ｓｋｉｎ Ｃａｎｃｅｒ 23(3), 364-366, 2008
- … The lesion was pathologically diagnosed as erythroplasia of Queyrat (EQ) by skin biopsy taken in another hospital; …
- NAID 130001078905
Related Links
- Erythroplakia (also known as "Erythroplasia" :734) is a flat red patch or lesion in the mouth that cannot be attributed to any other pathology. :805. A similar term is "erythroplasia", which has a papular appearance.
- erythroplasia /eryth·ro·pla·sia/ (-pla´zhah) a condition of the mucous membranes characterized by erythematous papular lesions. erythroplasia of Queyrat a form of epithelial dysplasia, ranging in severity from mild disorientation of epithelial ...
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