English Journal

Superior activity of a new histone deacetylase inhibitor (ZYJ-34c) in inhibiting growth of human leukemia cells by inducing p21WAF1 expression and cell cycle arrest.

Yang H1, Xu W, Li Y, Lan P, Zhang J, Zhang Y, Zhang C.
Anti-cancer drugs.Anticancer Drugs.2014 Aug;25(7):767-77. doi: 10.1097/CAD.0000000000000101.
Histone deacetylase inhibitors are a new class of anticancer agents that inhibit cancer cell proliferation and induce apoptosis and cell cycle arrest in various cancer cells. Recently, we identified ZYJ-34c, a modified histone deacetylase inhibitor that showed significantly higher antitumor activity
PMID 24686006

The cytotoxicity of the anticancer drug elesclomol is due to oxidative stress indirectly mediated through its complex with Cu(II).

Hasinoff BB1, Yadav AA2, Patel D2, Wu X2.
Journal of inorganic biochemistry.J Inorg Biochem.2014 Aug;137:22-30. doi: 10.1016/j.jinorgbio.2014.04.004. Epub 2014 Apr 16.
Elesclomol is an anticancer drug that is currently undergoing clinical trials. Elesclomol forms a strong 1:1 complex with Cu(II) and may exert its anticancer activity through the induction of oxidative stress and/or its ability to transport copper into the cell. A UV-vis spectrophotometric titration
PMID 24798374

Niflumic acid affects store-operated Ca(2+)-permeable (SOC) and Ca (2+)-dependent K (+) and Cl (-) ion channels and induces apoptosis in K562 cells.

Kucherenko YV1, Lang F.
The Journal of membrane biology.J Membr Biol.2014 Jul;247(7):627-38. doi: 10.1007/s00232-014-9680-x. Epub 2014 May 25.
Non-steroidal anti-inflammatory drugs (NSAIDs) are known to induce apoptosis in a variety of cancer cells. However, the precise mechanisms by which NSAIDs facilitate apoptosis in tumor cells are not clear. In the present study, we show that niflumic acid (NA), a member of the fenamates group of NSAI
PMID 24858951

Japanese Journal

Oxidative Stress Induces GSTP1 and CYP3A4 Expression in the Human Erythroleukemia Cell Line, K562 (Biochemistry/Molecular Biology)

Nagai Fusako,Kato Eriko,Tamura Hiro-omi
Biological & pharmaceutical bulletin 27(4), 492-495, 2004-04-01
… To explore the effects of oxidative stress on metabolizing enzymes in blood cells, we examined the effect of hydrogen peroxide (H_2O_2) on glutathione S-transferase (GST) and cytochrome P450 (CYP) expression in a human erythroleukemic cell line, K562. …
NAID 110003608792

Phorbol myristate acetate stimulates degradation of a structural analogue of platelet-activating factor to a neutral lipid in human leukemic K562 cells: Relevance to the release of lipids

Tsutsumi Toshihiko,Tokumura Akira,Yamaguchi Masaya [他],Kitazawa S,Tanigawara Y
Biological & pharmaceutical bulletin 27(1), 24-28, 2004-01-01
… In our attempt to investigate the mechanism of the release of platelet-activating factor (PAF) from cells, the erythroleukemic cell line K562 was preloaded with a radiolabeled PAF analogue having an ethylcarbamyl residue, 1-O-octadecyl-2-O-ethylcarbamyl-sn-glycero-3-phosphocholine (ethylcarbamyl-PAF), that is resistant to the hydrolytic action of PAF acetylhydrolase. …
NAID 110003608612