English Journal

Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function.

Jimenez-Vargas JM, Restano-Cassulini R, Quintero-Hernandez V, Gurrola GB, Possani LD.SourceDepartment of Molecular Medicine and Bioprocesses, Institute of Biotechnology, National Autonomous University of Mexico, Av. Universidad, 2001, P. O. Box 501-3, Cuernavaca 62210, Mexico. jimenez@ibt.unam.mx
Peptides.Peptides.2011 Mar;32(3):560-7. Epub 2010 Jun 30.
Ergtoxin 1 (ErgTx1) is a 42 amino acid peptide purified from the venom of the Mexican scorpion Centruroides noxius Hoffmann, capable of blocking specifically human potassium channels of the ether-a-go-go-related gene family (hERG). This peptide binds to a partially overlapping site on the channel o
PMID 20600425

Friemel A, Zunkler BJ.SourceFederal Institute for Drugs and Medical Devices, D-53175 Bonn, Germany.
Toxicological sciences : an official journal of the Society of Toxicology.Toxicol Sci.2010 Apr;114(2):346-55. Epub 2010 Jan 13.
Several noncardiovascular drugs have the potential to induce Torsades de Pointes cardiac arrhythmias via blockade of the rapid component of the cardiac delayed rectifier K(+) current (I(Kr)), which is encoded by human ether-a-go-go-related gene (hERG). The aim of the present study was to characteri
PMID 20071423

Japanese Journal

西広吉,堀信顯,勝田信夫
日本薬理学雑誌 82(5), 321-333, 1983
… 人工灌流液中に保生した脳切片標本の誘発電位を指標として，suloctidilおよびdihydro-ergotoxinの低糖負荷時の脳機能保護作用につき検討した．1)モルモットの前梨状葉薄切切片標本を用い，外側嗅索の二連刺激に応答する誘発電位を皮質表面から記録しながら，正常時の約1/3(3mM)のグルコースを含むKrebs-Ringer液で10分間灌流すると，第1刺激に対する誘発電位振幅は5?7分後から著明にかつ可逆的に減少し，安定な実験再現性が …
NAID 130000760841

岡村好幸
岡山医学会雑誌 51(2), 371-383, 1939-02-28
… 4) Ins Blutgefäss injiziertes Histamin, Ergotoxin, Adrenalin, Yohimbin und Pilokarpin führen reichliche Speichelsekretion herbei. …
NAID 120002924164