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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/06 20:19:18」(JST)

Eprazinone (trade name Eftapan) is a mucolytic and bronchospasm relieving drug.^[1]

References[edit]

^ Spitzer, W. (1980). "The efficacy of eprazinone dihydrochloride (Eftapan) in double-blind studies". Fortschritte der Medizin 98 (22): (871–874). PMID 6997154. edit

This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.

Pharmacophore modeling, virtual screening, and in vitro testing reveal haloperidol, eprazinone, and fenbutrazate as neurokinin receptors ligands.

Krautscheid Y1, Senning CJ, Sartori SB, Singewald N, Schuster D, Stuppner H.
Journal of chemical information and modeling.J Chem Inf Model.2014 Jun 23;54(6):1747-57. doi: 10.1021/ci500106z. Epub 2014 Jun 12.
Neurokinin receptors (NKRs) have been shown to be involved in many physiological processes, rendering them promising novel drug targets, but also making them the possible cause for side effects of several drugs. Aiming to answer the question whether the binding to NKRs could have a share in the side
PMID 24849814

Effects of automated external lubrication on tablet properties and the stability of eprazinone hydrochloride.

Yamamura T1, Ohta T, Taira T, Ogawa Y, Sakai Y, Moribe K, Yamamoto K.
International journal of pharmaceutics.Int J Pharm.2009 Mar 31;370(1-2):1-7. doi: 10.1016/j.ijpharm.2008.11.007. Epub 2008 Nov 18.
We investigated the advantages of an external lubrication technique for tableting. A newly developed external lubricating system was applied to tableting in a rotary tablet press using magnesium stearate. The resulting tablets were compared with tablets produced by the conventional internal lubricat
PMID 19059327

Tanabe K1, Tsuboi H, Maejima H, Arai S, Katsuoka K.
Dermatology online journal.Dermatol Online J.2005 Dec 1;11(3):25.
A 68-year-old woman developed an upper respiratory tract infection in November 2002 and was treated with eprazinone hydrochloride, serrapeptase, carbocysteine and clarithromycin. Three days after the start of treatment, the patient noted erythema on her axilla, buttock and inguinal regions. The eryt
PMID 16409921

加瀬佳年 [他],薬師寺隆,瀬尾量,坂田盛行,鬼頭剛,高浜和夫,宮田健
日本薬理学雑誌 73(5), 605-624, 1977
… 50mg/kg，p.o.）では液量は減少傾向を示したが，fominoben（5，10mg/kg，i.v.），eprazinone（5mg/kg，i.v.; …
NAID 130000758796

高梨茂 [他],日野原好和,東平靖雄,神山博,鈴木秀昂,中野秀樹,扇谷正三郎,作間彰
藥學雜誌 95(8), 1002-1009, 1975-08-25
… Absorption, distribution, and excretion of an antitussive piperazine derivative, Eprazinone hydrochloride (I), in mice, rats, rabbits, and men were studied by autoradiography, liquid scintillation counting, and colorimetry. … The excretion of Eprazinone (Ia) from rat feces was greater than that from urine after both oral and intravenous administration. …
NAID 110003652171

リンク元	「エプラジノン」
拡張検索	「eprazinone hydrochloride」

Eprazinone
Systematic (IUPAC) name
	3-[4-(2-ethoxy-2-phenyl-ethyl)piperazin-1-yl]-2-methyl-1-phenyl-propan-1-one
Clinical data
Trade names	Eftapan
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	10402-90-1
ATC code	R05CB04
PubChem	CID 3245
UNII	883YNL63WU
KEGG	D07902
Chemical data
Formula	C24H32N2O2
Mol. mass	380.523 g/mol
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