epidermal growth factor domains

出典: meddic


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英文文献

  • PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.
  • Jeong J1, VanHouten JN1, Dann P1, Kim W1, Sullivan C2, Yu H3, Liotta L4, Espina V4, Stern DF5, Friedman PA6, Wysolmerski JJ7.
  • Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2016 Jan 19;113(3):E282-90. doi: 10.1073/pnas.1516138113. Epub 2016 Jan 4.
  • In the lactating mammary gland, the plasma membrane calcium ATPase2 (PMCA2) transports milk calcium. Its expression is activated in breast cancers, where high tumor levels predict increased mortality. We find that PMCA2 expression correlates with HER2 levels in breast cancers and that PMCA2 interact
  • PMID 26729871
  • Molecular and functional characterization of the vitellogenin receptor in oriental river prawn, Macrobrachium nipponense.
  • Bai H1, Qiao H2, Li F1, Fu H3, Jiang S2, Zhang W2, Yan Y4, Xiong Y2, Sun S2, Jin S5, Gong Y2, Wu Y2.
  • Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2016 Jan 7. pii: S1095-6433(16)00003-9. doi: 10.1016/j.cbpa.2015.12.008. [Epub ahead of print]
  • A complementary DNA (cDNA) that encodes the vitellogenin receptor (VgR) in the oriental river prawn, Macrobrachium nipponense, was cloned using expressed sequence tag analysis and a rapid amplification of cDNA ends approach. The coding region consists of 5920 base pairs (bp) that encode a 1902 amino
  • PMID 26773480
  • KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation.
  • Han XR1,2,3, Zha Z1,2,3, Yuan HX1,2, Feng X1,2,3, Xia YK1,2,3, Lei QY1,4, Guan KL1,2,4,5, Xiong Y1,2,3,6.
  • Oncogene.Oncogene.2016 Jan 4. doi: 10.1038/onc.2015.482. [Epub ahead of print]
  • KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis. KDM2B contains multiple functional domains, including a JmjC domain that catalyzes H3K36 demethylation and a CxxC zinc-finger that recognizes CpG islands and recruits the polyc
  • PMID 26725323

和文文献

  • Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation
  • Fukaya Shinji,Matsui Yuki,Tomaru Utano,Kawakami Ai,Sogo Sayuri,Bohgaki Toshiyuki,Atsumi Tatsuya,Koike Takao,Kasahara Masanori,Ishizu Akihiro
  • Laboratory Investigation 93(1), 72-80, 2013-01
  • … TNF-α converting enzyme (TACE) can cleave transmembrane proteins, such as TNF-α, TNF receptors, and epidermal growth factor receptor (EGFR) ligands, to release the extracellular domains from the cell surface. …
  • NAID 120005301697
  • A Brief History of Tumor Necrosis Factor α – converting Enzyme: An Overview of Ectodomain Shedding
  • Horiuchi Keisuke
  • The Keio Journal of Medicine 62(1), 29-36, 2013
  • … Many membrane-bound molecules are cleaved at the cell surface, thereby releasing their extracellular domains. … Tumor necrosis factor α (TNFα)-converting enzyme (TACE/ADAM17) was originally identified as an enzyme responsible for releasing the membrane-bound TNFα precursor. …
  • NAID 130003366388
  • Effects of Halogenation on Tyrosine Phosphorylation and Peptide Binding to the Src Homology 2 Domain of Lymphocyte-Specific Protein Tyrosine Kinase
  • Okamura Toshimitsu,Kikuchi Tatsuya,Nodaira Mika [他],Odaka Kenichi,Fukushi Kiyoshi,Irie Toshiaki
  • Biological and Pharmaceutical Bulletin 35(3), 433-437, 2012
  • … It has been reported that nitration of tyrosine residue caused peptides to be a poor substrate for PTK and that nitrotyrosine residues could bind to SH2 domains as a phosphotyrosine mimic to activate Src family kinase. … We examined the phosphorylation of model peptides containing 3-halotyrosine or 3-nitrotyrosine using typical receptor tyrosine kinase, epidermal growth factor receptor (EGFR), and nonreceptor tyrosine kinase, lymphocyte-specific protein tyrosine kinase (Lck). …
  • NAID 130001872328

関連リンク

Epidermal growth factor (red) and its receptor (blue). The inactive form (left) dimerizes when it binds to the hormone (right). The cell membrane is shown ... The cells in your body constantly communicate with each other, negotiating ...
Figure 1 Schematic structure of EGFR. The EGFR monomer possesses an extracellular domain consisting of two ligand-binding subdomains (L1 and L2) and two cysteine-rich domains (S1 and S2), of which S1 ...

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★リンクテーブル★
関連記事grow」「growth」「factor」「fact」「domain

grow」

  [★]

  • v.
(過去: grew-過去分詞: grown)
extendgrowthoutgrowoutgrowthstretch

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「cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here"」
raise, farm, produce

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「come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts"」
develop, produce, get, acquire

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「become attached by or as if by the process of growth; "The tree trunks had grown together"」

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「become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"」

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「cause to grow or develop; "He grows vegetables in his backyard"」

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「increase in size by natural process; "Corn doesn''t grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesn''t grow much anymore"」

PrepTutorEJDIC   license prepejdic

「『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)」

growth」

  [★]

  • n.
  • 成長


WordNet   license wordnet

「(biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children"」
growing, maturation, development, ontogeny, ontogenesis

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「(pathology) an abnormal proliferation of tissue (as in a tumor)」

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「a progression from simpler to more complex forms; "the growth of culture"」

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「something grown or growing; "a growth of hair"」

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「vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"」

PrepTutorEJDIC   license prepejdic

「〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)」

factor」

  [★]

  • n.
elementelementaryfactorialparameter

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「be a contributing factor; "make things factor into a company''s profitability"」

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「any of the numbers (or symbols) that form a product when multiplied together」

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「an independent variable in statistics」

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「anything that contributes causally to a result; "a number of factors determined the outcome"」

PrepTutorEJDIC   license prepejdic

「(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize」

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「consider as relevant when making a decision; "You must factor in the recent developments"」
factor in, factor out

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「resolve into factors; "a quantum computer can factor the number 15"」
factor in, factor out

fact」

  [★]

  • n.
actualactuallyin factin practiceindeedpractically

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「an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"」

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「a concept whose truth can be proved; "scientific hypotheses are not facts"」

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「a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"」

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「a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"」

PrepTutorEJDIC   license prepejdic

「〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行」

domain」

  [★]

  • n.
arearealmregionregionalsegregationterritoryuniverse

WordNet   license wordnet

「territory over which rule or control is exercised; "his domain extended into Europe"; "he made it the law of the land"」
demesne, land

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「(mathematics) the set of values of the independent variable for which a function is defined」
domain of a function

PrepTutorEJDIC   license prepejdic

「(国の)領地,領土;(個人の)所有地 / (関心・活動などの)範囲,分野 / (個人・一族の)所有地 / (数学で)変域(関数の独立変数がとる値の集合)」




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