- 同
- EPF
WordNet
- of or relating to eosinophil
- a leukocyte readily stained with eosin (同)eosinophile
- inflammation of a hair follicle
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/17 14:51:20」(JST)
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| Eosinophilic folliculitis |
| Classification and external resources |
| eMedicine |
med/687 |
Eosinophilic folliculitis (also known as "Eosinophilic pustular folliculitis" and "Sterile eosinophilic pustulosis"[1]) is an itchy rash with an unknown cause that is most common among individuals with HIV, though it can occur in HIV-negative individuals where it is known by the eponym Ofuji disease.[2] EF consists of itchy red bumps (papules) centered on hair follicles and typically found on the upper body, sparing the abdomen and legs. The name eosinophilic folliculitis refers to the predominant immune cells associated with the disease (eosinophils) and the involvement of the hair follicles.
Contents
- 1 Epidemiology
- 2 Pathophysiology
- 3 Diagnosis
- 4 Treatment
- 5 See also
- 6 References
Epidemiology
Eosinophilic folliculitis associated with HIV infection typically affects individuals with advanced HIV and low T helper cell counts.[3] It affects both men and women as well as children with HIV and is found throughout the world.
EF may also affect individuals with hematologic disease such as leukemia and lymphoma.[4] It may also affect otherwise normal infants in a self-limited form.[5] HIV-negative individuals can also develop EF — this is more common in Japan.[6]
Pathophysiology
The cause of EF is unknown. A variety of microorganisms have been implicated, including the mite Demodex,[7] the yeast Pityrosporum,[8] and bacteria.[9] An autoimmune process has also been investigated.[10]
Diagnosis
Eosinophilic folliculitis may be suspected clinically when an individual with HIV exhibits the classic symptoms. The diagnosis can be supported by the finding of eosinophilia but a skin biopsy is necessary to establish it. Skin biopsies reveal lymphocytic and eosinophilic inflammation around the hair follicles.
Treatment
Treatment of eosinophilic folliculitis in people with HIV typically begins with the initiation of Highly Active Anti-Retroviral Therapy in order to help reconstitute the immune system. Direct treatment of the EF itself focuses on decreasing the inflammation and itching. Topical corticosteroids and oral antihistamines can alleviate the itching and decrease the size and number of lesions. Treatment with the antifungal drug itraconazole, the antibiotic metronidazole, and the anti-mite drug permethrin may lead to some improvement of symptoms. Other therapies include PUVA, topical tacrolimus, and isotretinoin.[11]
See also
- Eosinophilic pustular folliculitis of infancy
- List of cutaneous conditions
References
- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
- ^ Ofuji, S; Ogino, A; Horio, T; Oseko, T; Uehara, M (1970). "Eosinophilic pustular folliculitis". Acta dermato-venereologica 50 (3): 195–203. PMID 4193219.
- ^ Parker, SR; Parker, DC; McCall, CO (2006). "Eosinophilic folliculitis in HIV-infected women: case series and review". American journal of clinical dermatology 7 (3): 193–200. doi:10.2165/00128071-200607030-00006. PMID 16734507.
- ^ Patrizi, A; Chieregato, C; Visani, G; Morrone, P; Patrone, P (2004). "Leukaemia-associated eosinophilic folliculitis (Ofuji's disease)". Journal of the European Academy of Dermatology and Venereology : JEADV 18 (5): 596–8. doi:10.1111/j.1468-3083.2004.00982.x. PMID 15324404.
- ^ Buckley, DA; Munn, SE; Higgins, EM (2001). "Neonatal eosinophilic pustular folliculitis". Clinical and experimental dermatology 26 (3): 251–5. doi:10.1046/j.1365-2230.2001.00807.x. PMID 11422167.
- ^ Teraki, Y; Nishikawa, T (2005). "Skin diseases described in Japan 2004". Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 3 (1): 9–25. doi:10.1046/j.1439-0353.2005.04076.x. PMID 16353745.
- ^ Bodokh, I; Lacour, JP; Perrin, C; Bourdet, JF; Ortonne, JP (1994). "Papular eruption in AIDS: role of demodectic mites?". Acta dermato-venereologica 74 (4): 320–2. PMID 7976100.
- ^ Ferrándiz, C; Ribera, M; Barranco, JC; Clotet, B; Lorenzo, JC (1992). "Eosinophilic pustular folliculitis in patients with acquired immunodeficiency syndrome". International Journal of Dermatology 31 (3): 193–5. doi:10.1111/j.1365-4362.1992.tb03934.x. PMID 1568818.
- ^ Smith, KJ; Skelton, HG; Yeager, J; Ruiz, N; Wagner, KF (1995). "Metronidazole for eosinophilic pustular folliculitis in human immunodeficiency virus type 1-positive patients". Archives of dermatology 131 (9): 1089–91. doi:10.1001/archderm.131.9.1089. PMID 7661619.
- ^ Fearfield, LA; Rowe, A; Francis, N; Bunker, CB; Staughton, RC (1999). "Itchy folliculitis and human immunodeficiency virus infection: clinicopathological and immunological features, pathogenesis and treatment". The British journal of dermatology 141 (1): 3–11. doi:10.1046/j.1365-2133.1999.02914.x. PMID 10417509.
- ^ Ellis, E; Scheinfeld, N (2004). "Eosinophilic pustular folliculitis: a comprehensive review of treatment options". American journal of clinical dermatology 5 (3): 189–97. doi:10.2165/00128071-200405030-00007. PMID 15186198.
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Disorders of skin appendages (L60–L75, 703–706)
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|
| Nail |
- thickness: Onychogryphosis
- Onychauxis
- color: Beau's lines
- Yellow nail syndrome
- Leukonychia
- Azure Lunula
- shape: Koilonychia
- Nail clubbing
- behavior: Onychotillomania
- Onychophagia
- other: Ingrown nail
- Anonychia
- ungrouped: Paronychia
- Chevron nail
- Congenital onychodysplasia of the index fingers
- Green nails
- Half and half nails
- Hangnail
- Hapalonychia
- Hook nail
- Ingrown nail
- Lichen planus of the nails
- Longitudinal erythronychia
- Malalignment of the nail plate
- Median nail dystrophy
- Mees' lines
- Melanonychia
- Muehrcke's lines
- Nail–patella syndrome
- Onychoatrophy
- Onycholysis
- Onychomadesis
- Onychomatricoma
- Onychomycosis
- Onychophosis
- Onychoptosis defluvium
- Onychorrhexis
- Onychoschizia
- Platonychia
- Pincer nails
- Plummer's nail
- Psoriatic nails
- Pterygium inversum unguis
- Pterygium unguis
- Purpura of the nail bed
- Racquet nail
- Red lunulae
- Shell nail syndrome
- Splinter hemorrhage
- Spotted lunulae
- Staining of the nail plate
- Stippled nails
- Subungual hematoma
- Terry's nails
- Twenty-nail dystrophy
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| Hair |
|
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| Sweat glands |
| Eccrine |
- Miliaria
- Colloid milium
- Miliaria crystalline
- Miliaria profunda
- Miliaria pustulosa
- Miliaria rubra
- Occlusion miliaria
- Postmiliarial hypohidrosis
- Granulosis rubra nasi
- Ross’ syndrome
- Anhidrosis
- Hyperhidrosis
- Generalized
- Gustatory
- Palmoplantar
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|
| Apocrine |
- Body odor
- Chromhidrosis
- Fox–Fordyce disease
|
|
| Sebaceous |
|
|
|
|
Index of skin appendages
|
|
| Description |
- Anatomy
- Physiology
- Development
|
|
| Disease |
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
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| Treatment |
|
|
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UpToDate Contents
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English Journal
- Eosinophilic Skin Diseases: A Comprehensive Review.
- Long H1, Zhang G1, Wang L2, Lu Q3.
- Clinical reviews in allergy & immunology.Clin Rev Allergy Immunol.2016 Apr;50(2):189-213. doi: 10.1007/s12016-015-8485-8.
- Eosinophilic skin diseases, commonly termed as eosinophilic dermatoses, refer to a broad spectrum of skin diseases characterized by eosinophil infiltration and/or degranulation in skin lesions, with or without blood eosinophilia. The majority of eosinophilic dermatoses lie in the allergy-related gro
- PMID 25876839
- Case of generalized eosinophilic pustular folliculitis induced by allopurinol.
- Fujii M1,2, Takahashi I1, Kishiyama K3, Honma M2, Ishida-Yamamoto A2.
- The Journal of dermatology.J Dermatol.2016 Apr;43(4):458-9. doi: 10.1111/1346-8138.13223. Epub 2015 Dec 15.
- PMID 26666426
- Eosinophilic pustular folliculitis associated with hematological disorders: A report of two cases and review of Japanese literature.
- Takamura S1, Teraki Y1.
- The Journal of dermatology.J Dermatol.2016 Apr;43(4):432-5. doi: 10.1111/1346-8138.13088. Epub 2015 Sep 12.
- Eosinophilic pustular folliculitis (EPF) occurs in patients with hematological disorders. However, clinical information about hematological disorder-associated EPF is scarce. We report two cases of EPF associated with mantle cell lymphoma and reviewed the available published work on Japanese cases.
- PMID 26362415
Japanese Journal
- 症例 タクロリムス軟膏が奏効した好酸球性膿疱性毛包炎の1例
- 好酸球性膿疱性毛包炎 : 最近の病態研究 (特集 最近のトピックス2012 Clinical Dermatology 2012) -- (皮膚疾患の病態)
Related Links
- 10 Aug 2011 ... Eosinophilic Pustular Folliculitis. In 1965, Ise and Ofuji described a 42-year-old Japanese housewife with a possible follicular variant of subcorneal pustular dermatosis.
Related Pictures
★リンクテーブル★
[★]
- 英
- pustulosis
[★]
- 英
- eosinophilic pustular folliculitis
- 同
- 好酸球性膿疱性毛嚢炎？、好酸球性膿疱性皮膚症 eosinophilic pustular dermatosis、太藤病 Ofuji disease
- 関
- 好酸球
[★]
- 同
- eosinophilic pustular folliculitis
[★]
- 好酸球性の、好酸球の、好酸性の、好酸の、エオシン好性の、エオジン好性の
- 関
- acidophil、acidophile、acidophilic、eosinophil
