WordNet

of or relating to eosinophil
a leukocyte readily stained with eosin (同)eosinophile
an immature leukocyte normally found in bone marrow

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/15 10:33:26」(JST)

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Basophilic^[1]

Eosinophilic^[2]

Neutrophilic^[3]

A myelocyte is a young cell of the granulocytic series, occurring normally in bone marrow (can be found in circulating blood when caused by certain diseases).

Histology

When stained with the usual dyes, the cytoplasm is distinctly basophilic and relatively more abundant than in myeloblasts or promyelocytes, even though myelocytes are smaller cells.

Numerous cytoplasmic granules are present in the more mature forms of myelocytes. Neutrophilic and eosinophilic granules are peroxidase-positive, while basophilic granules are not.

The nuclear chromatin is coarser than that observed in myelocyte, but it is relatively faintly stained and lacks a well defined membrane.

The nucleus is fairly regular in contour (not indented), and seems to be 'buried' beneath the numerous cytoplasmic granules. (If the nucleus were indented, it would likely be a metamyelocyte.)

Maturation

Myelocytes are derived from promyelocytes and give rise to metamyelocytes.

Measurement

There is an internationally agreed method of counting blasts, with results from M1 upwards.

Additional images

Hematopoiesis

References

^ Histology image:01809loa from Vaughan, Deborah (2002). A Learning System in Histology: CD-ROM and Guide. Oxford University Press. ISBN 978-0195151732.
^ Histology image:01810loa from Vaughan, Deborah (2002). A Learning System in Histology: CD-ROM and Guide. Oxford University Press. ISBN 978-0195151732.
^ Histology image:01804loa from Vaughan, Deborah (2002). A Learning System in Histology: CD-ROM and Guide. Oxford University Press. ISBN 978-0195151732.

External links

Neutrophilic Myelocyte Presented by the University of Virginia
Eosinophilic Myelocyte Presented by the University of Virginia
Basophilic Myelocyte Presented by the University of Virginia
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UpToDate Contents

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1. 好酸球増加症候群の臨床症状、病態生理、および診断 clinical manifestations pathophysiology and diagnosis of the hypereosinophilic syndromes
2. 末梢血塗抹標本の評価 evaluation of the peripheral blood smear
3. 急性骨髄性白血病における細胞遺伝学 cytogenetics in acute myeloid leukemia
4. 正常好中球の発生および動態 normal neutrophil development and kinetics
5. 好中球二次顆粒欠損症 neutrophil specific granule deficiency

English Journal

Basophils and allergic inflammation.

Siracusa MC1, Kim BS, Spergel JM, Artis D.Author information 1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa.AbstractBasophils were discovered by Paul Ehrlich in 1879 and represent the least abundant granulocyte population in mammals. The relative rarity of basophils and their phenotypic similarities with mast cells resulted in this cell lineage being historically overlooked, both clinically and experimentally. However, recent studies in human subjects and murine systems have shown that basophils perform nonredundant effector functions and significantly contribute to the development and progression of TH2 cytokine-mediated inflammation. Although the potential functions of murine and human basophils have provoked some controversy, recent genetic approaches indicate that basophils can migrate into lymphoid tissues and, in some circumstances, cooperate with other immune cells to promote optimal TH2 cytokine responses in vivo. This article provides a brief historical perspective on basophil-related research and discusses recent studies that have identified previously unappreciated molecules and pathways that regulate basophil development, activation, and function in the context of allergic inflammation. Furthermore, we highlight the unique effector functions of basophils and discuss their contributions to the development and pathogenesis of allergic inflammation in human disease. Finally, we discuss the therapeutic potential of targeting basophils in preventing or alleviating the development and progression of allergic inflammation.
The Journal of allergy and clinical immunology.J Allergy Clin Immunol.2013 Oct;132(4):789-801; quiz 788. doi: 10.1016/j.jaci.2013.07.046.
Basophils were discovered by Paul Ehrlich in 1879 and represent the least abundant granulocyte population in mammals. The relative rarity of basophils and their phenotypic similarities with mast cells resulted in this cell lineage being historically overlooked, both clinically and experimentally. Ho
PMID 24075190

Cyclopamine induces eosinophilic differentiation and upregulates CD44 expression in myeloid leukemia cells.

Takahashi T1, Kawakami K, Mishima S, Akimoto M, Takenaga K, Suzumiya J, Honma Y.Author information 1Department of Life Science, Shimane University School of Medicine, 89-1 Enya, Izumo, Shimane 693-8501, Japan.AbstractCyclopamine, a plant-derived steroidal alkaloid, inhibits the hedgehog (Hh) signaling pathway by antagonizing Smoothened. This drug can induce the differentiation of myeloid leukemia cell lines and acute myeloid leukemia (AML) cells in primary culture. The treated cells were stained with Luxol-fast-blue, which is specific for eosinophilic granules. Ligation of CD44 with some specific monoclonal antibodies can reverse the differentiation of AML cells. Combined treatment with cyclopamine and a monoclonal antibody to ligate CD44 more than additively induced the differentiation of HL-60 cells. These results may provide useful information for the development of a CD44-targeted therapy in AML.
Leukemia research.Leuk Res.2011 May;35(5):638-45. doi: 10.1016/j.leukres.2010.09.022. Epub 2010 Oct 23.
Cyclopamine, a plant-derived steroidal alkaloid, inhibits the hedgehog (Hh) signaling pathway by antagonizing Smoothened. This drug can induce the differentiation of myeloid leukemia cell lines and acute myeloid leukemia (AML) cells in primary culture. The treated cells were stained with Luxol-fast-
PMID 20971508

Japanese Journal

犬腫瘍に関する病理学的研究 : III.膵臓の腺房細胞癌(Acinar cell carcinoma)と好酸球の浸潤を伴った細網細胞肉腫(Reticulum cell sarcoma)

安田宣紘,坂本司,河野猪三郎
鹿兒島大學農學部學術報告 32, 125-132, 1982-03-19
犬の膵臓と下顎リンパ節に原発した腫瘍2例について病理学的に検査を行い次の結果をえた.第1例, ブルドック種, 3歳, 雌, 鹿児島市産臨床的に著明な腹水と黄疸症状を示し, 剖検により膵臓, 肝臓, 横隔膜, 大網, 脾臓, 肺に種瘍を認め, とくに膵頭(右葉)のものが最大で, 15×8×9cm大にもよんだ.これらの腫瘍はほぼ同様の組織像を呈し, 蜂巣状に増殖した腫瘍細胞からなり, 腫瘍細胞は円形, …
NAID 110004993219

骨髄組織培養に於ける墨粒貪喰能の研究第二編健康人及び家兎骨髄内細胞の墨粒貪喰能に就て

角南宏
岡山医学会雑誌 68(8), 1179-1189, 1956-08-31
… The results are as follow: 1) The majority of neutrophilic leukocytes such as myeloblast and promyelocyte but a few exceptions of myelocyte exhibited no phagocytosis. … The pseudo-eosinophilic leukocyte of rabbit bone marrow was much weaker in its phagocytic activity than the neutrophilic leukocyte. … Pseudo-eosinophilic leukocyte showed its highest value of the average degree of phagocytosis after 6 hours’ cultivation. …
NAID 120002426716