WordNet

of or relating to eosinophil
an inflammation of body tissue (especially that below the skin) characterized by fever and swelling and redness and pain
a leukocyte readily stained with eosin (同)eosinophile

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/03 04:37:09」(JST)

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Eosinophilic cellulitis, also known as Wells' syndrome, is a skin disease that presents with painful, red, raised, and warm patches of skin.^[2] The rash comes on suddenly, lasts for a few weeks, and often repeatedly comes back.^[2] Scar formation does not typically occur.^[1]

Eosinophilic cellulitis is of unknown cause.^[2] It is suspected to be an autoimmune disorder.^[2] It may be triggered by bites from insects such as spiders, fleas, or ticks, or from medications or surgery.^[2] Diagnosis is made after other potential cases are ruled out.^[1] Skin biopsy of the affected areas may show an increased number of eosinophils.^[2] Other conditions that may appear similar include cellulitis, contact dermatitis, and severe allergic reactions such as anaphylaxis.^[2]

Treatment is often with a corticosteroids.^[2] Steroids applied as a cream is generally recommended over the use of steroids by mouth.^[3] Antihistamines may be used to help with itchiness.^[1] Many times the condition goes away after a few weeks without treatment.^[2] The condition is uncommon with about 200 described cases.^[1] It affects both sexes with the same frequency.^[2] It was first described by George Crichton Wells in 1971.^[4]^[1]

Cause

Eosinophilic cellulitis is of unknown cause.^[2] It is suspected to be an autoimmune disorder.^[2] It may be triggered by bites from insects such as spiders, fleas, or ticks, or from medications or surgery.^[2]

Diagnosis

Histology of a skin biopsy from acute phase eosinophilic cellulitis. Note findings of plentiful tissue eosinophils and flame figures at the deeper chorium sections (hematoxylin & eosin, original magnification ×40).

Diagnosis requires ruling out other potential causes.^[1] This includes ruling out vasculitis on skin biopsy.^[1]

Treatment

Treatment is often with a steroids.^[2] This can be either applied as a cream or taken by mouth.^[3] As the condition tends to get better on its own taking steroids by mouth should generally only be tried if the rash covers a large area and it does not get better with other measures.^[3]

References

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k Weins, AB; Biedermann, T; Weiss, T; Weiss, JM (October 2016). "Wells syndrome.". Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. 14 (10): 989–993. PMID 27767278.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u "Familial Eosinophilic Cellulitis - NORD (National Organization for Rare Disorders)". NORD (National Organization for Rare Disorders). 2009. Retrieved 10 April 2017.
^ ^a ^b ^c Räßler, F; Lukács, J; Elsner, P (September 2016). "Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review.". Journal of the European Academy of Dermatology and Venereology : JEADV. 30 (9): 1465–79. PMID 27357601.
^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.

External links

DermNet NZ entry

UpToDate Contents

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1. Hypereosinophilic syndromes: Clinical manifestations, pathophysiology, and diagnosis
2. 好酸球の生物学および好酸球増多症の原因 eosinophil biology and causes of eosinophilia
3. 蕁麻疹性血管炎 urticarial vasculitis
4. クリオピリン関連周期性発熱症候群および関連疾患 cryopyrin associated periodic syndromes and related disorders
5. Antimicrobial stewardship

English Journal

Methodological challenges in monitoring new treatments for rare diseases: lessons from the cryopyrin-associated periodic syndrome registry.

Tilson H, Primatesta P, Kim D, Rauer B, Hawkins PN, Hoffman HM, Kuemmerle-Deschner J, van der Poll T, Walker UA.AbstractBACKGROUND: The Cryopyrin-Associated Periodic Syndromes (CAPS) are a group of rare hereditary autoinflammatory diseases and encompass Familial Cold Autoinflammatory Syndrome (FCAS), Muckle-Wells Syndrome (MWS), and Neonatal Onset Multisystem Inflammatory Disease (NOMID). Canakinumab is a monoclonal antibody directed against IL-1 beta and approved for CAPS patients but requires post-approval monitoring due to low and short exposures during the licensing process. Creative approaches to observational methodology are needed, harnessing novel registry strategies to ensure Health Care Provider reporting and patient monitoring.
Orphanet journal of rare diseases.Orphanet J Rare Dis.2013 Sep 10;8(1):139. [Epub ahead of print]
BACKGROUND: The Cryopyrin-Associated Periodic Syndromes (CAPS) are a group of rare hereditary autoinflammatory diseases and encompass Familial Cold Autoinflammatory Syndrome (FCAS), Muckle-Wells Syndrome (MWS), and Neonatal Onset Multisystem Inflammatory Disease (NOMID). Canakinumab is a monoclonal
PMID 24016338

Wells syndrome and its relationship to Churg-Strauss syndrome.

Ratzinger G, Zankl J, Zelger B.SourceDepartment of Dermatology and Venereology, Medical University Innsbruck, Anichstrasse 35, Innsbruck, Austria. gudrun.ratzinger@i-med.ac.at
International journal of dermatology.Int J Dermatol.2013 Aug;52(8):949-54. doi: 10.1111/j.1365-4632.2012.05482.x. Epub 2013 Jun 20.
BACKGROUND: Wells syndrome has been described as an inflammatory disorder based on typical clinical appearance combined with the histopathological presence of eosinophilic infiltrates and flame figures in the absence of vasculitis. Churg-Strauss syndrome, on the other hand, is primarily a diffus
PMID 23786445

Eosinophilic annular erythema is a peculiar subtype in the spectrum of Wells syndrome: a multicentre long-term follow-up study.

El-Khalawany M, Al-Mutairi N, Sultan M, Shaaban D.SourceDepartment of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. makhalawany@gmail.com
Journal of the European Academy of Dermatology and Venereology : JEADV.J Eur Acad Dermatol Venereol.2013 Aug;27(8):973-9. doi: 10.1111/j.1468-3083.2012.04616.x. Epub 2012 Jun 25.
BACKGROUND/OBJECTIVE: Eosinophilic annular erythema (EAE) was proposed to describe annular skin lesions associated with tissue eosinophilia, however, its relation to Well's syndrome (WS) remains a source of controversy. We studied a series of patients to increase awareness of this entity and to clar
PMID 22731886

Japanese Journal

症例報告四肢の浮腫と末梢血好酸球増多を呈した2例

佐藤真美,植田郁子,光井千慧 [他]
臨床皮膚科 = Japanese journal of clinical dermatology 68(8), 601-606, 2014-07
NAID 40020150956

臍炎を契機に川崎病様症状を呈した好酸球性蜂窩織炎の1例

大杉康司,森雅亮,大山宜孝 [他],小川真喜子,塩島裕樹,森尾郁子,海老名奏子,藤塚麻子,原田知典,武下草生子,菊池信行,横田俊平
日本小児科学会雑誌 115(12), 1908-1913, 2011-12-01
NAID 10030289140

5.好酸球性膿疱性毛包炎と好酸球性蜂窩織炎(IX.好酸球増多を主徴とする疾患,専門医のためのアレルギー学講座)

信藤肇,田中麻衣子,秀道広
アレルギー 60(6), 667-675, 2011-06-30
NAID 110008673087

Related Pictures

★リンクテーブル★

リンク元	「好酸球性蜂巣炎」
関連記事	「eosinophilic」

「好酸球性蜂巣炎」

Eosinophilic cellulitis
Synonyms	Wells' syndrome, recurrent granulomatous dermatitis with eosinophilia
	Initial rash in eosinophilic cellulitis
Specialty	Dermatology
Symptoms	Painful, red, raised, warm patches of skin
Usual onset	Sudden and recurrent
Duration	Few weeks
Causes	Unknown
Similar conditions	Vasculitis, cellulitis, anaphylaxis
Medication	Corticosteroids, antihistamines
Prognosis	Often goes away by itself
Frequency	~200 documented cases
	[edit on Wikidata]

　　[★]

英: eosinophilic cellulitis

「eosinophilic」

　　[★]

adj.

好酸球性の、好酸球の、好酸性の、好酸の、エオシン好性の、エオジン好性の

関: acidophil、acidophile、acidophilic、eosinophil

[We2016-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k Weins, AB; Biedermann, T; Weiss, T; Weiss, JM (October 2016). "Wells syndrome.". Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. 14 (10): 989–993. PMID 27767278.

[NORD2009-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u "Familial Eosinophilic Cellulitis - NORD (National Organization for Rare Disorders)". NORD (National Organization for Rare Disorders). 2009. Retrieved 10 April 2017.

[Ra2016-3] Räßler, F; Lukács, J; Elsner, P (September 2016). "Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review.". Journal of the European Academy of Dermatology and Venereology : JEADV. 30 (9): 1465–79. PMID 27357601.

[Bol2007-4] Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.

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eosinophilic cellulitis