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1. 好酸球の生物学および好酸球増多症の原因 eosinophil biology and causes of eosinophilia
2. 原因不明の好酸球増加症患者に対するアプローチ approach to the patient with unexplained eosinophilia
3. 好中球二次顆粒欠損症 neutrophil specific granule deficiency
4. 好酸球増加症候群：臨床症状、病態生理および診断 hypereosinophilic syndromes clinical manifestations pathophysiology and diagnosis
5. 喘息の病因 pathogenesis of asthma

Extracellular Eosinophil Granule Protein Deposition in Ringed Esophagus with Sparse Eosinophils.

Peterson KA1, Cobell WJ, Clayton FC, Krishnamurthy C, Ying J, Pease LF 3rd, Saffari H, Georgelas A, Fang J, Gleich GJ, Leiferman KM.
Digestive diseases and sciences.Dig Dis Sci.2015 Sep;60(9):2646-53. doi: 10.1007/s10620-015-3665-1. Epub 2015 Apr 23.
BACKGROUND: Eosinophilic esophagitis (EoE) remains difficult to classify because of varying presentations. Not uncommonly, patients present with symptoms of esophageal dysfunction and have esophageal changes on endoscopy resembling EoE but without >15 eosinophils/HPF. Patients with low numbers of
PMID 25902747

Bouffi C1, Kartashov AV1, Schollaert KL1, Chen X2, Bacon WC1, Weirauch MT3, Barski A4, Fulkerson PC5.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Aug 12. pii: 1500510. [Epub ahead of print]
The production of mature eosinophils (Eos) is a tightly orchestrated process with the aim to sustain normal Eos levels in tissues while also maintaining low numbers of these complex and sensitive cells in the blood. To identify regulators of homeostatic eosinophilopoiesis in mice, we took a global a
PMID 26268651

Expression and subcellular localization of the Qa-SNARE syntaxin17 in human eosinophils.

Carmo LA1, Dias FF1, Malta KK1, Amaral KB1, Shamri R2, Weller PF2, Melo RC3.
Experimental cell research.Exp Cell Res.2015 Aug 6:ECR15273. doi: 10.1016/j.yexcr.2015.07.003. [Epub ahead of print]
BACKGROUND: SNARE members mediate membrane fusion during intracellular trafficking underlying innate and adaptive immune responses by different cells. However, little is known about the expression and function of these proteins in human eosinophils, cells involved in allergic, inflammatory and immun
PMID 26254897

A novel in-frame deletion in the leucine zipper domain of C/EBPε leads to neutrophil-specific granule deficiency

Wada Taizo,Akagi Tadayuki,Muraoka Masahiro,Toma Tomoko,Kaji Kenzo,Agematsu Kazunaga,Koeffler Phillip,Yokota Takashi,Yachie Akihiro
Journal of Immunology 195(1), 80-86, 2015-07-01
… Neutrophil-specific granule deficiency (SGD) is a rare autosomal recessive primary immunodeficiency characterized by neutrophil dysfunction, bilobed neutrophil nuclei and lack of neutrophil-specific granules. … The ΔRS mutant was defective in its association with Gata1 and PU.1, as well as aberrant cooperative transcriptional activation of eosinophil major basic protein. …
NAID 120005647665

Expression Levels of Eosinophil Granule Protein mRNAs in Induced Sputum Reflect Airway Hyperresponsiveness and Airflow Limitation

Jung Jae-Woo,Kang Hye-Ryun,Lee Hyun-Seung,Park Heung-Woo,Cho Sang Heon,Min Kyung-Up,Sohn Seong-Wook
The Tohoku Journal of Experimental Medicine 233(1), 49-56, 2014
… Activation of eosinophils induces extracellular release of a number of eosinophil granule proteins, including major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO), and eosinophil-derived neurotoxin. …
NAID 130004460127

Eosinophilic Myocarditis due to Churg-Strauss Syndrome With Markedly Elevated Eosinophil Cationic Protein

Hara Tomoya,Yamaguchi Koji,Iwase Takashi,Kadota Muneyuki,Bando Mika,Ogasawara Kozue,Bando Sachiko,Ise Takayuki,Niki Toshiyuki,Ueda Yuka,Tomita Noriko,Taketani Yoshio,Yamada Hirotsugu,Soeki Takeshi,Wakatsuki Tetsuzo,Sata Masataka
International Heart Journal 54(1), 51-53, 2013
… Laboratory data showed leukocytosis, hypereosinophilia (10,450/<I>μ</I>L), troponin T(+), elevated BNP, and markedly elevated eosinophil cationic protein (ECP) (> … Eosinophilic granule proteins, such as ECP and major basic protein, play important roles in the pathogenesis of eosinophilic myocarditis. …
NAID 130003364440