WordNet

(medicine) the act of caring for someone (as by medication or remedial training etc.); "the quarterback is undergoing treatment for a knee injury"; "he tried every treatment the doctors suggested"; "heat therapy gave the best relief"
any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

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Lacosamide Serum Concentrations in Adult Patients With Epilepsy: The Influence of Gender, Age, Dose, and Concomitant Antiepileptic Drugs.

Markoula S1, Teotonio R, Ratnaraj N, Duncan JS, Sander JW, Patsalos PN.Author information 1*Epilepsy Society, Chalfont Centre for Epilepsy, Chalfont St Peter; †Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology; and ‡National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.AbstractOBJECTIVE:: Lacosamide (LCM), a new antiepileptic drug (AED) approved as adjunctive therapy for the treatment of patients with partial-onset seizures, has limited pharmacokinetic and drug interaction data. The main objectives of the present study were to investigate the effects of dose, age, gender, and hepatic enzyme-inducing AEDs on the pharmacokinetics of LCM as assessed by steady state serum LCM values.
Therapeutic drug monitoring.Ther Drug Monit.2014 Feb 19. [Epub ahead of print]
OBJECTIVE:: Lacosamide (LCM), a new antiepileptic drug (AED) approved as adjunctive therapy for the treatment of patients with partial-onset seizures, has limited pharmacokinetic and drug interaction data. The main objectives of the present study were to investigate the effects of dose, age, gender,
PMID 24562047

Enzyme-inducing Anticonvulsants Increase Plasma Clearance of Dexmedetomidine: A Pharmacokinetic and Pharmacodynamic Study.

Flexman AM1, Wong H, Riggs KW, Shih T, Garcia PA, Vacas S, Talke PO.Author information 1From the Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada (A.M.F.); Drug Metabolism and Pharmacokinetics, Genentech Inc., San Francisco, California (H.W.); Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (K.W.R.); and Department of Neurology (T.S., P.A.G.), Department of Anesthesia and Perioperative Care (S.V., P.O.T.), University of California San Francisco, San Francisco, California.AbstractBACKGROUND:: Dexmedetomidine is useful during mapping of epileptic foci as it facilitates electrocorticography unlike most other anesthetic agents. Patients with seizure disorders taking enzyme-inducing anticonvulsants appear to be resistant to its sedative effects. The objective of the study was to compare the pharmacokinetic and pharmacodynamic profile of dexmedetomidine in healthy volunteers with volunteers with seizure disorders receiving enzyme-inducing anticonvulsant medications.
Anesthesiology.Anesthesiology.2014 Jan 30. [Epub ahead of print]
BACKGROUND:: Dexmedetomidine is useful during mapping of epileptic foci as it facilitates electrocorticography unlike most other anesthetic agents. Patients with seizure disorders taking enzyme-inducing anticonvulsants appear to be resistant to its sedative effects. The objective of the study was to
PMID 24487703

Chemotherapy and immunotherapy of brain tumors: what the epileptologist must know.

Rogers LR.Author information Department of Neurology, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, Ohio, U.S.A.AbstractI present an overview of therapy for the most common brain tumors encountered in clinical practice if adult patients. Current therapy paradigms and evolving therapies are reviewed. The introduction of non-enzyme-inducing antiepileptic drugs (NEIADs) has simplified the approach to combined medical treatment of epilepsy and brain tumors, but the major interactions between enzyme-inducing antiepileptic drugs (EIAEDs) are included, to serve as guidance in selecting these medications if they are required.
Epilepsia.Epilepsia.2013 Dec;54 Suppl 9:105-8. doi: 10.1111/epi.12453.
I present an overview of therapy for the most common brain tumors encountered in clinical practice if adult patients. Current therapy paradigms and evolving therapies are reviewed. The introduction of non-enzyme-inducing antiepileptic drugs (NEIADs) has simplified the approach to combined medical tr
PMID 24328882