出典: meddic



  • Crystal Structure of 2A Proteinase from Hand, Foot and Mouth Disease Virus.
  • Mu Z, Wang B, Zhang X, Gao X, Qin B, Zhao Z, Cui S.SourceMOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, 9 Dong Dan San Tiao, Beijing 100730, People's Republic of China.
  • Journal of molecular biology.J Mol Biol.2013 Nov 15;425(22):4530-43. doi: 10.1016/j.jmb.2013.08.016. Epub 2013 Aug 23.
  • EV71 is responsible for several epidemics worldwide; however, the effective antiviral drug is unavailable to date. The 2A proteinase (2A(pro)) of EV71 presents a promising drug target due to its multiple roles in virus replication, inhibition of host protein synthesis and evasion of innate immunity.
  • PMID 23973886
  • Autoprocessing: an essential step for expression and purification of enterovirus 71 3C(pro) in Escherichia coli.
  • Huang S, Lyu Y, Qing X, Wang W, Tang L, Cheng K, Wang W.SourceKey Laboratory of Biosynthesis of Natural Products, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Ministry of Health of PRC, Beijing, 100050, China, ahuanqsq@imm.ac.cn.
  • Biotechnology letters.Biotechnol Lett.2013 Nov;35(11):1845-52. doi: 10.1007/s10529-013-1284-5. Epub 2013 Jul 24.
  • A gene encoding the 3BC of human enterovirus 71 (EV71) was cloned and inserted into a derivative of plasmid pET-32a(+) driven by T7 promoter. The expressed 3C protease (3C(pro)) autocatalytically cleaved itself from the recombinant protein Trx-3BC and the mature 3C(pro) partitioned in the soluble fr
  • PMID 23881322
  • Coxsackievirus B4 can infect human pancreas ductal cells and persist in ductal-like cell cultures which results in inhibition of Pdx1 expression and disturbed formation of islet-like cell aggregates.
  • Sane F, Caloone D, Gmyr V, Engelmann I, Belaich S, Kerr-Conte J, Pattou F, Desailloud R, Hober D.SourceLaboratoire de Virologie/ EA3610, Université Lille 2, Faculté de Médecine, CHRU, 59120, Loos-lez-Lille, France.
  • Cellular and molecular life sciences : CMLS.Cell Mol Life Sci.2013 Nov;70(21):4169-80. doi: 10.1007/s00018-013-1383-4. Epub 2013 Jun 18.
  • The role of enteroviruses, especially Coxsackievirus B (CVB), in type 1 diabetes is suspected, but the mechanisms of the virus-induced or aggravated pathogenesis of the disease are unknown. The hypothesis of an enterovirus-induced disturbance of pancreatic β-cells regeneration has been investigated
  • PMID 23775130


  • 兵庫県の感染症発生動向調査において検出されたエンテロウイルス(2008~2012年)
  • 榎本 美貴,髙井 伝仕,押部 智宏 [他]
  • 兵庫県立健康生活科学研究所健康科学研究センター研究報告 (4), 13-18, 2013
  • NAID 40019749205
  • Molecular Epidemiology of Human Enterovirus 71 Strains in the Nanchang Region of China in 2011
  • Zhou Xianfeng,Fan Guoyin,Xia Wen,He Fenglan,Hu Maohong,Ni Xiansheng,Zhang Yue,Chen Haiying
  • Japanese Journal of Infectious Diseases 66(2), 149-150, 2013
  • … Hand, foot, and mouth disease (HFMD) is caused by enteroviruses, most commonly enterovirus 71 (EV71) and coxsackievirus A16 (CA16). … Enteroviruses were detected in 62.2% (405/651) of the specimens. … EV71, CA16, and other enteroviruses were found in 292, 73, and 40 specimens, respectively. …
  • NAID 130003381658
  • 平成23年に高知県で流行したエンテロウイルス
  • 松本 一繁,鍋島 民,細見 卓司 [他]
  • 高知県衛生研究所報 (58), 31-34, 2012
  • NAID 40019706101







enterovirus, Enterovirus
  • ここではエンテロウイルス属に属するウイルスの総称をエンテロウイルスと呼ぶことにする



  • 不顕性感染となるのは99%らしい (SMB.43)


  • 夏~初秋
  • 小児多いが大人も発症




  • エンテロウイルスxx型 (xx:通し番号)


  • 血清型非特異的なその他のエンテロウイルスによる感染症(血清型が非常に多い)
  • 特定の血清型による感染症


  [★] エンテロウイルス

WordNet   license wordnet

「any of a group of picornaviruses that infect the gastrointestinal tract and can spread to other areas (especially the nervous system)」