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neuron-specific enolasephosphopyruvate hydratase

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/08/23 22:48:15」(JST)

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  • Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents.
  • Alvaro-Bartolomé M, García-Sevilla JA.SourceLaboratori de Neurofarmacologia, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears (UIB) and Redes Temáticas de Investigación Cooperativa en Salud (RETICS-RTA), Cra. Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain.
  • Neuroscience.Neuroscience.2013 Sep 5;247:294-308. doi: 10.1016/j.neuroscience.2013.05.035. Epub 2013 May 29.
  • The endocannabinoid system is implicated in the neurobiology of cocaine addiction. This study evaluated the status of cannabinoid (CB) CB1 and CB2 receptors, the endocytic cycle of CB1 receptors, G protein-coupled receptor regulatory kinases (GRK), and associated signaling (mammalian target of rapam
  • PMID 23727505
  • Lipid peroxidation triggers neurodegeneration: A redox proteomics view into the Alzheimer disease brain.
  • Sultana R, Perluigi M, Allan Butterfield D.SourceDepartment of Chemistry, Center of Membrane Sciences, and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.
  • Free radical biology & medicine.Free Radic Biol Med.2013 Sep;62:157-69. doi: 10.1016/j.freeradbiomed.2012.09.027. Epub 2012 Oct 5.
  • Lipid peroxidation involves a cascade of reactions in which production of free radicals occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty acids easily undergo lipid peroxidation chain reactions, which, in turn, lead to the formation of highly reactive electrophi
  • PMID 23044265
  • Loss of caveolin-1 promotes endothelial-mesenchymal transition during sepsis: A membrane proteomic study.
  • Huang X, Pan L, Pu H, Wang Y, Zhang X, Li C, Yang Z.SourceSichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China.
  • International journal of molecular medicine.Int J Mol Med.2013 Sep;32(3):585-92. doi: 10.3892/ijmm.2013.1432. Epub 2013 Jul 5.
  • Sepsis is a clinical syndrome that reflects an uncontrolled systemic inflammatory response to microbial infections. Endothelial cells, which are highly responsive to their extracellular environment, are the primary targets of sepsis-induced damage. Endothelial-mesenchymal transition (EndMT), charact
  • PMID 23836408


  • Proinsulin C-peptide activates α-enolase : implications for C-peptide-cell membrane interaction
  • Ishii Tatsuya,Fukano Keigo,Shimada Kohei [他]
  • Journal of Biochemistry 152(1), 53-62, 2012-07
  • NAID 40019351035
  • Somatic embryogenesis and mass spectrometric identification of proteins related to somatic embryogenesis in Eruca sativa
  • Chen Kan,Wu Hai-Jun,Chen Jian-Feng [他]
  • Plant biotechnology reports 6(2), 113-122, 2012-04
  • NAID 40019231069


Enolase, also known as phosphopyruvate hydratase, is a metalloenzyme responsible for the catalysis of the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis. The chemical reaction ...


Structural equation for EnolaseEnolase converts 2-phosphoglycerate to enolaseEnolase catalyzes: 2-phosphoglycerate Yeast enolase dimer. [1]Enolase (Saccharomyces cerevisiae)

リンク元解糖系」「エノラーゼ」「phosphopyruvate hydratase
拡張検索neuron specific enolase」「neuron-specific enolase」「indophenolase



glycolytic pathway
エムデン-マイヤーホフ経路 Embden-Meyerhof pathway
  • CH(OH)-CH(OH)-C(OH)H-CH(OH)-C(CH2OH)H-O- グルコース (OHが↓↓↑↓↑)
  • CH(OH)-CH(OH)-C(OH)H-CH(OH)-C(CH2O-PO3)H-O- グルコース-6-リン酸 (OHが↓↓↑↓↑)
  • C(CH2OH)OH-C(OH)H-CH(OH)-C(CH2O-PO3)H-O- フルクトース-6-リン酸
  • C(CH2O-PO3)OH-C(OH)H-CH(OH)-C(CH2O-PO3)H-O- フルクトース-1,6-リン酸
glucose 6-phosphate
↓-phosphohexose isomerase
fructose 6-phosphate
fructose 1,6-bisphosphate
glyceraldehyde 3-phosphate
↓-glyceraldehyde-3-phosphate dehydrogenase
↓-phosphoglycerate kinase →ATP
↓-phosphoglyceate mutase
↓-pyruvate kinase → ATP
 -(pyruvate dehydrogenase)→acetyl-CoA
 -(pyruvate carboxylase)→oxaloacetate-(NADH+H+)→malate

解糖系の酵素 (first aid step1 2006 p.87, FASTEP1_87_酵素一覧.xls)

1 galactokinase キナーゼ  
2 galactose-1-phosphate uridyltransferase 転移酵素  
3 hexokinase/glucokinase キナーゼ  
4 glucose-6-phosphatase ホスファターゼ  
5 glucose-6-phosphate dehydrogenase 脱水素酵素  
6 transketolase    
7 phosphofructokinase キナーゼ  
8 fructose-1,6-bisphosphatase ホスファターゼ  
9 fructokinase キナーゼ フルクトキナーゼ
10 aldolase B   アルドラーゼ
11 pyruvate kinase キナーゼ ピルビン酸キナーゼ
12 pyruvate dehydrogenase 脱水素酵素 ピルビン酸デヒドロゲナーゼ
13 HMG-CoA reductase 還元酵素 HMG-CoA還元酵素
14 pyruvate carboxylase カルボキシラーゼ ピルビン酸カルボキシラーゼ
15 PEP carboxykinase キナーゼ PEPカルボキシキナーゼ
16 citrate synthase 合成酵素 クエン酸合成酵素
17 α-ketoglutarate dehydrogenase 脱水素酵素 α-ケトグルタミン酸脱水素酵素
18 ornithine transcarbamylase 転移酵素 オルニチンカルバモイルトランスフェラーゼ



神経特異性エノラーゼ NSE


  • 2-ホスホグリセリン酸を脱水し、ホスホエノールピルビン酸を生じる反応を触媒する解糖系酵素である。
  • 二量体であり、α、β、γサブユニットからなる。赤血球などを多く含む組織(αα型)、骨格筋(αβ型、ββ型)、神経組織(γγ型、αγ型)が見られる。

phosphopyruvate hydratase」



enolaseneuron-specific enolase

neuron specific enolase」

  [★] 神経特異性エノラーゼ NSE

neuron-specific enolase」

  [★] 神経特異性エノラーゼ


  [★] インドフェノラーゼ

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