エンドセリン受容体、エンドセリンレセプター

WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

=sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/04 20:42:27」(JST)

wiki en

There are at least four known endothelin receptors, ET_A, ET_B1, ET_B2 and ET_C,^[1] all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium,^[2] which constricts the smooth muscles of the blood vessels, raising blood pressure, or relaxes the smooth muscles of the blood vessels, lowering blood pressure, among other functions.

Physiological functions

ET_A is a subtype for vasoconstriction^[1] These receptors are found in the smooth muscle tissue of blood vessels, and binding of endothelin to ET_A increases vasoconstriction (contraction of the blood vessel walls) and the retention of sodium, leading to increased blood pressure.^[3]
ET_B1 mediates vasodilation,^[1] When endothelin binds to ET_B1 receptors, this leads to the release of nitric oxide (also called endothelium-derived relaxing factor), natriuresis and diuresis (the production and elimination of urine) and mechanisms that lower blood pressure.
ET_B2 mediates vasoconstriction^[1]
ET_C has yet no clearly defined function.^[1]
ET receptor are also found in the nervous system where they may mediate neurotransmission and vascular functions.^[4]

Brain and nerves

Widely distributed in the body, receptors for endothelin are present in blood vessels and cells of the brain, choroid plexus and peripheral nerves. When applied directly to the brain of rats in picomolar quantities as an experimental model of stroke, endothelin-1 caused severe metabolic stimulation and seizures with substantial decreases in blood flow to the same brain regions, both effects mediated by calcium channels.^[5]

A similar strong vasoconstrictor action of endothelin-1 was demonstrated in a peripheral neuropathy model in rats.^[6]

Clinical significance

Mutations in the EDNRB gene are associated with ABCD syndrome^[7] and some forms of Waardenburg syndrome.^[8]

References

^ ^a ^b ^c ^d ^e Medical physiology a cellular and molecular approach (2nd ed., International ed.). Philadelphia, PA: Saunders/Elsevier. 2009. p. 480. ISBN 9781437720174. |first1= missing |last1= in Authors list (help)
^ Davenport AP (2002). "International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature". Pharmacol. Rev. 54 (2): 219–26. doi:10.1124/pr.54.2.219. PMID 12037137.
^ Hynynen MM, Khalil RA; Khalil (January 2006). "The vascular endothelin system in hypertension--recent patents and discoveries". Recent Pat Cardiovasc Drug Discov. 1 (1): 95–108. doi:10.2174/157489006775244263. PMC 1351106. PMID 17200683.
^ Barnes K, Turner AJ; Turner (August 1997). "The endothelin system and endothelin-converting enzyme in the brain: molecular and cellular studies". Neurochem. Res. 22 (8): 1033–40. doi:10.1023/A:1022435111928. PMID 9239759.
^ Gross PM, Zochodne DW, Wainman DS, Ho LT, Espinosa FJ, Weaver DF; Zochodne; Wainman; Ho; Espinosa; Weaver (July 1992). "Intraventricular endothelin-1 uncouples the blood flow: metabolism relationship in periventricular structures of the rat brain: involvement of L-type calcium channels". Neuropeptides. 22 (3): 155–65. doi:10.1016/0143-4179(92)90158-S. PMID 1331845.
^ Zochodne DW, Ho LT, Gross PM; Ho; Gross (December 1992). "Acute endoneurial ischemia induced by epineurial endothelin in the rat sciatic nerve". Am. J. Physiol. 263 (6 Pt 2): H1806–10. PMID 1481904.
^ Verheij JB, Kunze J, Osinga J, van Essen AJ, Hofstra RM; Kunze; Osinga; Van Essen; Hofstra (2002). "ABCD syndrome is caused by a homozygous mutation in the EDNRB gene". Am. J. Med. Genet. 108 (3): 223–5. doi:10.1002/ajmg.10172. PMID 11891690.
^ Read AP, Newton VE; Newton (1997). "Waardenburg syndrome". J. Med. Genet. 34 (8): 656–65. doi:10.1136/jmg.34.8.656. PMC 1051028. PMID 9279758.

External links

"Endothelin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Endothelin receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 心不全におけるエンドセリンの役割 role of endothelin in heart failure
2. 成人における肺高血圧症の治療 treatment of pulmonary hypertension in adults
3. 進行性前立腺癌の治療に対する実験的アプローチ investigational approaches for the treatment of advanced prostate cancer
4. 狭心症の新しい治療法 new therapies for angina pectoris
5. ヒト免疫不全ウイルス（HIV）関連肺動脈性高血圧症 pulmonary arterial hypertension associated with human immunodeficiency virus

English Journal

Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent.

Gandía J1, Morató X1, Stagljar I2, Fernández-Dueñas V3, Ciruela F4.
Behavioural brain research.Behav Brain Res.2015 Jul 15;288:103-6. doi: 10.1016/j.bbr.2015.04.001. Epub 2015 Apr 9.
GPR37, also known as parkin associated endothelin-like receptor (Pael-R), is an orphan GPCR that aggregates intracellularly in a juvenile form of Parkinson's disease. However, little is known about the function of this orphan receptor. Here, using a model for parkisonian tremor, the pilocarpine-indu
PMID 25862943

Cerebrovascular endothelin-1 hyper-reactivity is associated with transient receptor potential canonical channels 1 and 6 activation and delayed cerebral hypoperfusion after forebrain ischaemia in rats.

Johansson SE1, Andersen XE1, Hansen RH2, Povlsen GK1, Edvinsson L1,3.
Acta physiologica (Oxford, England).Acta Physiol (Oxf).2015 Jul;214(3):376-89. doi: 10.1111/apha.12519. Epub 2015 Jun 4.
AIM: In this study, we aimed to investigate whether changes in cerebrovascular voltage-dependent calcium channels and non-selective cation channels contribute to the enhanced endothelin-1-mediated vasoconstriction in the delayed hypoperfusion phase after experimental transient forebrain ischaemia.ME
PMID 25939574

Neuropeptide Y receptor mediates activation of ERK1/2 via transactivation of the IGF receptor.

Lecat S1, Belemnaba L2, Galzi JL3, Bucher B2.
Cellular signalling.Cell Signal.2015 Jul;27(7):1297-304. doi: 10.1016/j.cellsig.2015.03.016. Epub 2015 Mar 25.
Neuropeptide Y binds to G-protein coupled receptors whose action results in inhibition of adenylyl cyclase activity. Using HEK293 cells stably expressing the native neuropeptide Y Y1 receptors, we found that the NPY agonist elicits a transient phosphorylation of the extracellular signal-regulated ki
PMID 25817573

Japanese Journal

Bladder Endothelin-1 Receptor Binding of Bosentan and Ambrisentan

Osano Ayaka,Yokoyama Yoshinari,Hayashi Hideki [他]
Journal of pharmacological sciences 124(1), 86-91, 2014-01
NAID 40019949017

Autoimmune Hepatitis in a Patient with Pulmonary Arterial Hypertension Treated with Endothelin Receptor Antagonists

Naito Akira,Terada Jiro,Tanabe Nobuhiro,Sugiura Toshihiko,Sakao Seiichiro,Kanda Tatsuo,Yokosuka Osamu,Tatsumi Koichiro
Internal Medicine 53(7), 771-775, 2014
A 48-year-old woman was diagnosed with idiopathic pulmonary arterial hypertension (PAH) and administered PAH-specific therapies, including bosentan. Four years after the initiation of treatment with b …
NAID 130003392737

Rolling Nagoya Mouse Strain (PROD-rol/rol) with Classic Piebald Mutation

YOSHIMOTO Takuro,AOYAMA Yo,KIM Tae Yeon,NIIMI Kimie,TAKAHASHI Eiki,ITAKURA Chiitoshi
Journal of Veterinary Medical Science, 2014
… However, mutation analysis of the s locus encoding the endothelin receptor type B (Ednrb) gene in PROD-rol/rol mice had not been performed. …
NAID 130003391327

★リンクテーブル★

リンク元	「エンドセリン受容体」「エンドセリンレセプター」

「エンドセリン受容体」

endothelin receptor type B
Identifiers
Symbol	EDNRB
Alt. symbols	HSCR2, HSCR
Entrez	1910
HUGO	3180
OMIM	131244
RefSeq	NM_000115
UniProt	P24530
Other data
Locus	Chr. 13 q22

endothelin receptor type A
Identifiers
Symbol	EDNRA
Entrez	1909
HUGO	3179
OMIM	131243
RefSeq	NM_001957
UniProt	P25101
Other data
Locus	Chr. 4 q31.2

　　[★]

英: endothelin receptor
関: エンドセリンレセプター

「エンドセリンレセプター」

　　[★]

英: endothelin receptor
関: エンドセリン受容体

[boron-1] Medical physiology a cellular and molecular approach (2nd ed., International ed.). Philadelphia, PA: Saunders/Elsevier. 2009. p. 480. ISBN 9781437720174. |first1= missing |last1= in Authors list (help)

[pmid12037137-2] Davenport AP (2002). "International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature". Pharmacol. Rev. 54 (2): 219–26. doi:10.1124/pr.54.2.219. PMID 12037137.

[pmid17200683-3] Hynynen MM, Khalil RA; Khalil (January 2006). "The vascular endothelin system in hypertension--recent patents and discoveries". Recent Pat Cardiovasc Drug Discov. 1 (1): 95–108. doi:10.2174/157489006775244263. PMC 1351106. PMID 17200683.

[pmid9239759-4] Barnes K, Turner AJ; Turner (August 1997). "The endothelin system and endothelin-converting enzyme in the brain: molecular and cellular studies". Neurochem. Res. 22 (8): 1033–40. doi:10.1023/A:1022435111928. PMID 9239759.

[pmid1331845-5] Gross PM, Zochodne DW, Wainman DS, Ho LT, Espinosa FJ, Weaver DF; Zochodne; Wainman; Ho; Espinosa; Weaver (July 1992). "Intraventricular endothelin-1 uncouples the blood flow: metabolism relationship in periventricular structures of the rat brain: involvement of L-type calcium channels". Neuropeptides. 22 (3): 155–65. doi:10.1016/0143-4179(92)90158-S. PMID 1331845.

[pmid1481904-6] Zochodne DW, Ho LT, Gross PM; Ho; Gross (December 1992). "Acute endoneurial ischemia induced by epineurial endothelin in the rat sciatic nerve". Am. J. Physiol. 263 (6 Pt 2): H1806–10. PMID 1481904.

[pmid11891690-7] Verheij JB, Kunze J, Osinga J, van Essen AJ, Hofstra RM; Kunze; Osinga; Van Essen; Hofstra (2002). "ABCD syndrome is caused by a homozygous mutation in the EDNRB gene". Am. J. Med. Genet. 108 (3): 223–5. doi:10.1002/ajmg.10172. PMID 11891690.

[pmid9279758-8] Read AP, Newton VE; Newton (1997). "Waardenburg syndrome". J. Med. Genet. 34 (8): 656–65. doi:10.1136/jmg.34.8.656. PMC 1051028. PMID 9279758.

匿名

検索

案内

案内

endothelin receptor