WordNet

the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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Atrasentan in Patients With Advanced Renal Cell Carcinoma: A Phase 2 Trial of the ECOG-ACRIN Cancer Research Group (E6800).

Carducci MA1, Manola J2, Nair SG3, Liu G4, Rousey S5, Dutcher JP6, Wilding G7.
Clinical genitourinary cancer.Clin Genitourin Cancer.2015 Dec;13(6):531-539.e1. doi: 10.1016/j.clgc.2015.07.002. Epub 2015 Jul 17.
BACKGROUND: Atrasentan, an oral endothelin receptor A antagonist, demonstrated phase 1 activity in patients with renal cell carcinoma (RCC). A phase 2 study was undertaken in patients with measurable or bone-only metastatic RCC in the pre-VEGF/TKI era.METHODS AND MATERIALS: Patients were stratified
PMID 26272427

Endothelin A receptor drives invadopodia function and cell motility through the β-arrestin/PDZ-RhoGEF pathway in ovarian carcinoma.

Semprucci E1, Tocci P1, Cianfrocca R1, Sestito R1, Caprara V1, Veglione M1, Castro VD1, Spadaro F2, Ferrandina G3, Bagnato A1, Rosanò L1.
Oncogene.Oncogene.2015 Nov 2. doi: 10.1038/onc.2015.403. [Epub ahead of print]
The endothelin-1 (ET-1)/ET A receptor (ETAR) signalling pathway is a well-established driver of epithelial ovarian cancer (EOC) progression. One key process promoted by ET-1 is tumor cell invasion, which requires the scaffolding functions of β-arrestin-1 (β-arr1) downstream of the receptor; howeve
PMID 26522724

Endothelin ETA receptor antagonist reverses naloxone-precipitated opioid withdrawal in mice.

Bhalla S1, Pais G1, Tapia M2, Gulati A1.
Canadian journal of physiology and pharmacology.Can J Physiol Pharmacol.2015 Nov;93(11):935-44. doi: 10.1139/cjpp-2015-0022. Epub 2015 Apr 28.
Long-term use of opioids for pain management results in rapid development of tolerance and dependence leading to severe withdrawal symptoms. We have previously demonstrated that endothelin-A (ETA) receptor antagonists potentiate opioid analgesia and eliminate analgesic tolerance. This study was desi
PMID 26440527

Genetic factors associating the effects of habitual exercise on arterial stiffness

Iemitsu Motoyuki
The Journal of Physical Fitness and Sports Medicine 2(3), 325-332, 2013
… Recently, several studies reported that gene polymorphisms, such as atrial natriuretic peptide, endothelial nitric oxide synthase, estrogen receptor-α, endothelin receptor-A, endothelin receptor-B, angiotensinogen, angiotensin-converting enzyme, methylenetetrahydrofolate reductase and fatty acid binding protein 2, were associated with individual variation in the effects of physical exercise or cardiorespiratory fitness on arterial stiffness risks. …
NAID 130003379974

Vascular Endothelial σ1-Receptor Stimulation With SA4503 Rescues Aortic Relaxation via Akt/eNOS Signaling in Ovariectomized Rats With Aortic Banding

Tagashira Hideaki,Matsumoto Takayuki,Taguchi Kumiko,Zhang Chen,Han Feng,Ishida Keiko,Nemoto Shingo,Kobayashi Tsuneo,Fukunaga Kohji
Circulation Journal, 2013
… Background: We previously reported that σ1-receptor (σ1R) expression in the thoracic aorta decreased after pressure overload (PO) induced by abdominal aortic banding in ovariectomized (OVX) rats. … Vascular functions of isolated descending aorta were measured following phenylephrine (PE)- or endothelin-1 (ET-1)-induced vasoconstriction and acetylcholine (ACh)- or clonidine-induced vasodilation. …
NAID 130003361844

Oral Administration of a Novel Long-Acting Prostacyclin Agonist With Thromboxane Synthase Inhibitory Activity for Pulmonary Arterial Hypertension

Nakamura Atsuhiro,Nagaya Noritoshi,Obata Hiroaki,Sakai Katsuya,Sakai Yoshiki,Yoshikawa Masanori,Hamada Kaoru,Matsumoto Kunio,Kimura Hiroshi
Circulation Journal, 2013
… Kaplan-Meier survival curves demonstrated that the effect of ONO-1301 was equivalent to that of an endothelin receptor antagonist and a phosphodiesterase-5 inhibitor. …
NAID 130003361765