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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/12 21:56:19」(JST)

Prostaglandin H2 is a type of prostaglandin derived from arachidonic acid and a precursor for many other biologically significant molecules.

Eicosanoid synthesis - prostaglandin H2 near center

It is acted upon by:

Figure 1: Synthetic pathways from PGH₂ (the parent compound) to prostaglandins, prostacyclin and thromboxanes

This biochemistry article is a stub. You can help Wikipedia by expanding it.

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Effect of body-weight loading onto the articular cartilage on the occurrence of quinolone-induced chondrotoxicity in juvenile rats.

Goto K, Imaoka M, Goto M, Kikuchi I, Suzuki T, Jindo T, Takasaki W.SourceMedicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo 134-8630, Japan. Electronic address: goto.koichi.s7@daiichisankyo.co.jp.
Toxicology letters.Toxicol Lett.2013 Feb 4;216(2-3):124-9. doi: 10.1016/j.toxlet.2012.11.017. Epub 2012 Nov 29.
The effect of body-weight loading onto the articular cartilage on the occurrence of chondrotoxicity was investigated in male juvenile Sprague-Dawley rats given ofloxacin (OFLX) orally once at 900mg/kg. Just after dosing of OFLX, hindlimb unloading was performed for 0, 2, 4, or 8h by a tail-suspensio
PMID 23201441

In vitro evaluation of the cytotoxic and genotoxic effects of artemether, an antimalarial drug, in a gastric cancer cell line (PG100).

Alcântara DD, Ribeiro HF, Cardoso PC, Araújo TM, Burbano RR, Guimarães AC, Khayat AS, de Oliveira Bahia M.SourceHuman Cytogenetics Laboratory, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa, 01, CEP, 66075-110, Belém, PA, Brazil.
Journal of applied toxicology : JAT.J Appl Toxicol.2013 Feb;33(2):151-6. doi: 10.1002/jat.1734. Epub 2011 Sep 23.
Artemisinin is a sesquiterpene lactone endoperoxide, obtained from Artemisia annua, and extensively used as an antimalarial drug. Many studies have reported the genotoxic and cytotoxic effects of artemisinins; however, there are no studies that compare such effects between cancer cell lines and norm
PMID 21953315

中瀬朋夏,髙橋幸一
日本薬理学雑誌 146(3), 130-134, 2015
… にがん幹細胞増殖抑制作用を持つ小分子化合物として初めて同定され，がん幹細胞の撲滅による新しい乳がん治療法に有用である可能性が明らかにされた．他のセスキテルペノイド類においても，構造中のendoperoxide bridgeと鉄イオンとの反応によりフリーラジカル産生能力を持つマラリア特効薬，アルテミシニンやその誘導体において，がん細胞選択的な細胞毒性作用を発揮する．さらに，アルテミシニン誘導体の機能 …
NAID 130005097935

五十嵐和彦,解良洋平,加藤恭丈
日本毒性学会学術年会 39.1(0), S1-3, 2012
… また、MATIIはprostaglandin-endoperoxide synthase 2 (Ptgs2/Cox2)遺伝子の抑制に関わることも見いだした。 …
NAID 130005008948

後藤浩一,今岡尚子,後藤真由美,鈴木貴美,菊池勇,神藤敏正,三分一所厚司
日本毒性学会学術年会 39.1(0), P-154, 2012
… また、関節毒性発現への影響が示唆されているtumor necrosis factor receptor superfamily, member 12a（Tnfrsf12a）、prostaglandin-endoperoxide synthase 2（Ptgs2）、plasminogen activator, urokinase receptor（Plaur）、及びmatrix metalloproteinase 3（Mmp3）遺伝子（Goto et al., Toxicology. …
NAID 130005008754

リンク元	「エンドペルオキシド」「エンドパーオキサイド」
拡張検索	「prostaglandin-endoperoxide synthase」「synthetic prostaglandin endoperoxide」

Prostaglandin H2
Identifiers
CAS number	42935-17-1
PubChem	445049
ChemSpider	392800
MeSH	Prostaglandin+H2
ChEBI	CHEBI:15554
Jmol-3D images	Image 1
	SMILES O=C(O)CCC/C=C\C[C@H]2[C@H]1OO[C@H](C1)[C@@H]2/C=C/[C@@H](O)CCCCC ;
	InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 ; Key: YIBNHAJFJUQSRA-YNNPMVKQSA-N InChI=1/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1; Key: YIBNHAJFJUQSRA-YNNPMVKQBN ;
Properties
Molecular formula	C20H32O5
Molar mass	352.465 g/mol
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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	Infobox references