endoglin

Endoglin
Identifiers
Symbols	ENG; CD105; END; HHT1; ORW; ORW1
External IDs	OMIM: 131195 MGI: 95392 HomoloGene: 92 GeneCards: ENG Gene
Gene Ontology
Molecular function	• transmembrane signaling receptor activity; • transforming growth factor beta-activated receptor activity; • transforming growth factor beta receptor, cytoplasmic mediator activity; • type II transforming growth factor beta receptor binding; • type II transforming growth factor beta receptor binding; • protein binding; • protein binding; • galactose binding; • glycosaminoglycan binding; • glycosaminoglycan binding; • type I transforming growth factor beta receptor binding; • type I transforming growth factor beta receptor binding; • protein homodimerization activity; • protein homodimerization activity; • activin binding; • transforming growth factor beta binding;
Cellular component	• extracellular space; • membrane fraction; • nucleus; • nucleolus; • cytoplasm; • external side of plasma membrane; • cell surface; • transforming growth factor beta receptor homodimeric complex; • endothelial microparticle;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • chronological cell aging; • chronological cell aging; • patterning of blood vessels; • vasculogenesis; • response to hypoxia; • positive regulation of protein phosphorylation; • negative regulation of endothelial cell proliferation; • heart looping; • positive regulation of systemic arterial blood pressure; • cell migration involved in endocardial cushion formation; • regulation of transcription, DNA-dependent; • cell adhesion; • transforming growth factor beta receptor signaling pathway; • transforming growth factor beta receptor signaling pathway; • positive regulation of pathway-restricted SMAD protein phosphorylation; • positive regulation of pathway-restricted SMAD protein phosphorylation; • cell migration; • regulation of transforming growth factor beta receptor signaling pathway; • central nervous system vasculogenesis; • extracellular matrix disassembly; • regulation of cell adhesion; • negative regulation of cell migration; • BMP signaling pathway; • negative regulation of transforming growth factor beta receptor signaling pathway; • positive regulation of BMP signaling pathway; • negative regulation of protein autophosphorylation; • wound healing; • regulation of cell proliferation; • regulation of phosphorylation; • positive regulation of transcription from RNA polymerase II promoter; • smooth muscle tissue development; • artery morphogenesis; • venous blood vessel morphogenesis; • cell motility; • negative regulation of nitric-oxide synthase activity; • cell chemotaxis; • negative regulation of pathway-restricted SMAD protein phosphorylation; • detection of hypoxia;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/08/27 17:57:14」(JST)

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[Wiki en表示]

Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.

The protein consists of a homodimer of 180 kDA with disulfide links. ^[1] It has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells.

Endoglin has been found to be part of the TGF-beta1 receptor complex. It thus may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. Beside TGF-beta signaling endoglin may have other functions. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. ^[2] Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development . Experimental mice without the endoglin gene die due to cardiovascular abnormalities.^[2]

In humans endoglin may be involved in the autosomal dominant disorder known as hereditary hemorrhagic telangiectasia type 1.^[1] This condition leads to frequent nose bleeds, telangiectases on skin and mucosa and may cause arteriovenous malformations in different organs including brain, lung, and liver.

Endoglin levels have been found to be elevated in pregnant women who subsequently develop preeclampsia.^[3]

Interactions

Endoglin has been shown to interact with TGF beta receptor 2^[4]^[5] and TGF beta receptor 1.^[4]^[5]

References

^ ^a ^b Michelle Letarte. "Structure and function of endoglin, a component of the TGF- beta receptor, etc". University of Toronto. Archived from the original on 2006-09-29. http://web.archive.org/web/20060929141224/http://www.immunology.utoronto.ca/English/Structure-and-function-of-endoglin-a-component-of-the-TGF--beta-receptor-expressed-on-endothelial-cells-and-activated-monocytes-and-the-target-gene-for-the-vascular-dominant-genetic-disorderetc.html. Retrieved 2006-08-28.
^ ^a ^b Sanz-Rodriguez, Francisco; Mercedes Guerrero-Esteo, Luisa-Maria Botella, Denis Banville (2004). "Endoglin Regulates Cytoskeletal Organization through Binding to ZRP-1, a Member of the Lim Family of Proteins". J. Biol. Chem. 279 (31): 32858–68. doi:10.1074/jbc.M400843200. PMID 15148318.
^ Venkatesha, S; Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, Stillman IE, Roberts D, D'Amore PA, Epstein FH, Sellke FW, Romero R, Sukhatme VP, Letarte M, Karumanchi SA. (2006). "Soluble endoglin contributes to the pathogenesis of preeclampsia". Nat Med 12 (6): 642–9. doi:10.1038/nm1429. PMID 16751767.
^ ^a ^b Guerrero-Esteo, Mercedes; Sanchez-Elsner Tilman, Letamendia Ainhoa, Bernabeu Carmelo (Aug. 2002). "Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II". J. Biol. Chem. (United States) 277 (32): 29197–209. doi:10.1074/jbc.M111991200. ISSN 0021-9258. PMID 12015308.
^ ^a ^b Barbara, N P; Wrana J L, Letarte M (Jan. 1999). "Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily". J. Biol. Chem. (UNITED STATES) 274 (2): 584–94. doi:10.1074/jbc.274.2.584. ISSN 0021-9258. PMID 9872992.

External links

GeneReviews/NCBI/NIH/UW entry on Hereditary Hemorrhagic Telangiectasia
CD105+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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1. 子癇前症：病因 preeclampsia pathogenesis
2. 肺動静脈奇形：成人における疫学、病因、および病理 pulmonary arteriovenous malformations epidemiology etiology and pathology in adults
3. 遺伝性出血性毛細血管拡張症（オースラー・ウェーバー・ランデュ症候群） hereditary hemorrhagic telangiectasia osler weber rendu syndrome
4. 全身性硬化症（強皮症）の病因 pathogenesis of systemic sclerosis scleroderma
5. Juvenile polyposis syndrome

English Journal

Evaluation of biochemical markers combined with uterine artery Doppler parameters in fetuses with growth restriction: a case-control study.

Zamarian AC1, Araujo Júnior E2, Daher S1, Rolo LC1, Moron AF1, Nardozza LM1.
Archives of gynecology and obstetrics.Arch Gynecol Obstet.2016 Oct;294(4):715-23. doi: 10.1007/s00404-016-4024-y. Epub 2016 Feb 2.
PURPOSE: Assessing the biochemical markers levels and the uterine artery Doppler (UtA) parameters in fetuses with growth restriction (FGR).METHODS: Prospective case-control study included 66 patients with diagnosis of FGR and 64 healthy pregnancies at 24-41 weeks of gestation. For both groups, mate
PMID 26837385

Elevated placenta growth factor levels in the early second-trimester amniotic fluid are associated with preterm delivery.

Lee H1, Kwon JY1, Lee S2, Kim SJ1, Shin JC1, Park IY1.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.J Matern Fetal Neonatal Med.2016 Oct;29(20):3374-8. doi: 10.3109/14767058.2015.1127345. Epub 2016 Jan 8.
OBJECTIVE: The purpose of this study was to determine how angiogenesis-related factors correlate with preterm delivery.METHODS: A cohort of 382 pregnant women undergoing early second-trimester genetic amniocentesis was enrolled and followed-up until delivery, and the amniotic fluid was collected and
PMID 26634962

Rapid endoglin determination in serum samples using an amperometric magneto-actuated disposable immunosensing platform.

Torrente-Rodríguez RM1, Campuzano S2, Ruiz-Valdepeñas-Montiel V3, Pedrero M4, Fernández-Aceñero MJ5, Barderas R6, Pingarrón JM7.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2016 Sep 10;129:288-93. doi: 10.1016/j.jpba.2016.07.020. Epub 2016 Jul 15.
A sensitive and rapid method for the determination of the clinically relevant biomarker human endoglin (CD105) in serum samples is presented, involving a magneto-actuated immunoassay and amperometric detection at disposable screen-printed carbon electrodes (SPCEs). Micro-sized magnetic particles wer
PMID 27448312

Japanese Journal

MW-5-5 妊娠高血圧腎症患者血清中IgGの妊娠初期絨毛細胞よりのsoluble Endoglin,Cytokaine産生に対する影響(ミニワークショップ5 妊婦高血圧症候群の病態,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)

小林祐介,仲尾岳大,東裕福,中村晃和,市川剛,村瀬隆之,千島史尚,山本樹生
日本産科婦人科學會雜誌 66(2), 437, 2014-02-01
NAID 110009811536

中枢神経系における悪性リンパ腫研究の最近の進歩

杉田保雄
Neuro-Oncologyの進歩 20(1), 1-11, 2014
Primary central nervous system lymphoma (PCNSL) is a rare extranodal lymphomas. Histopathologically, PCNSLs typically show patchy, poorly demarcated, and angiocentric proliferation different from othe …
NAID 130004648348

4) 妊娠36週未満発症の妊娠高血圧腎症の発症予知法の改良 : 血中血管新生関連因子の正常域から疾患発症閾値への展開(シンポジウム2:周産期「妊娠高血圧症候群の基礎と臨床-予防・治療の新戦略に向けて」,第65回日本産科婦人科学会・学術講演会)

大口昭英
日本産科婦人科學會雜誌 65(11), 2604-2615, 2013-11-01
… and LR+s of angiogenesis-related factors, such as placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), soluble endoglin (sEng) and sFlt-1/PlGF ratio, are also<10. …
NAID 110009674984

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