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1. 食物中の微量ミネラルの概要overview of dietary trace minerals [show details]
… Chronic fluoride toxicity (fluorosis) is usually caused by high fluoride concentrations… goiter was endemic in certain parts of the world and the Midwestern United States. In one study, administration of iodine treated and prevented goiter in children in goiter-endemic areas of Ohio .…
2. 骨軟化症の疫学および病因epidemiology and etiology of osteomalacia [show details]
…Fluoride, which can cause osteomalacia when ingested in excessive quantities, as may occur in endemic fluorosis and with ingestion of fluoride toothpastes and certain teas . Hypophosphatasia is a rare …
3. 乳幼児への予防的デンタルケアおよびカウンセリングpreventive dental care and counseling for infants and young children [show details]
… 2002 . The dental effect of mild fluorosis is limited to surface appearance A 2010 systematic review found that mild fluorosis is not a cosmetic concern . Mild fluorosis is indicated by a white flecked …
4. 歯の発達障害developmental defects of the teeth [show details]
…enamel or fluorosis . The hypomineralization makes the teeth more susceptible to wear and breakage . Mild fluorosis is indicated by a white flecked or lacy appearance to the enamel ; severe fluorosis is indicated …
5. 血液透析に使用される水の混入物質contaminants in water used for hemodialysis [show details]
…considered safe for the general population, although fluoride has been associated with skeletal fluorosis in certain populations and possible kidney damage in children . The situation regarding patients …

English Journal

Dental fluorosis and oral health in the African Esophageal Cancer Corridor: Findings from the Kenya ESCCAPE case-control study and a pan-African perspective.

Menya D, Maina SK, Kibosia C, Kigen N, Oduor M, Some F, Chumba D, Ayuo P, Middleton DRS, Osano O, Abedi-Ardekani B, Schüz J, McCormack VA.
International journal of cancer. 2019 Jul;145(1)99-109.
There are no studies of oral health in relation to esophageal cancer in Africa, or of Eastern Africa's endemic dental fluorosis, an irreversible enamel hypo-mineralization due to early-life excessive fluoride intake. During 2014-18, we conducted a case-control study of squamous cell esophageal cance
PMID 30582155

[Level of exposure to fluorides by the consumption of different types of milk in residents from an area of Mexico with endemic hydrofluorosis].

Valdez Jiménez L, Calderón Hernández J, Córdova Atilano RI, Sandoval Aguilar SY, Alegría Torres JA, Costilla Salazar R, Rocha Amador D.
Anales de pediatria (Barcelona, Spain : 2003). 2019 Jun;90(6)342-348.
Several studies have shown the presence of fluorosis (DF) in primary dentition, suggesting an exposure to fluorides (F) in early childhood. Breast milk is recommended as an exclusive food until 6 months of age. Although it is mentioned that only a small amount of F can be eliminated by breast milk,
PMID 30660388

Silencing GSK3β instead of DKK1 can inhibit osteogenic differentiation caused by co-exposure to fluoride and arsenic.

Zeng Q, Xu Y, Yu X, Yang J, Hong F, Zhang A.
Bone. 2019 Jun;123()196-203.
Chronic exposure to combined fluoride (F) and arsenic (As) continues to be a major public health problem worldwide, attracting the attention of an increasing number of researchers. While bone is the main target organ of syndrome of endemic arsenic poisoning and fluorosis (SEAF), the specific mechani
PMID 30890376

Japanese Journal

Prevalence of Brick Tea-Type Fluorosis in the Tibet Autonomous Region

Fan Zhipeng,Gao Yanhui,Wang Wei,Gong Hongqiang,Guo Min,Zhao Shengcheng,Liu Xuehui,Yu Bing,Sun Dianjun
Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ 26(2), 57-63, 2016
… Background: The prevalence of brick tea-type fluorosis is high in Tibet because of the habit of drinking brick tea in this region. … Brick tea-type fluorosis has become an urgent public health problem in China. Methods: A cross-sectional survey was conducted to investigate prevalence of brick tea-type fluorosis in all districts of Tibet using a stratified cluster sampling method. …
NAID 130005124683

Why dose fluorosed dentine show a higher susceptibility for caries : An ultra-morphological explanation

Waidyasekera Kanchana,二階堂徹,Weerasinghe Dinesh,渡辺昭彦,市野瀬志津子,Tay Franklin,田上順次
Journal of Medical and Dental Sciences = Journal of medical and dental sciences 57(1), 17-23, 2010-03
… Background-Chronic endemic dental fluorosis is a malformation of teeth caused by excessive ingestion of fluoride during period of tooth development. … Information relating the effect of dental fluorosis with dentine crystallite and collagen structure is currently unavailable. …
NAID 120006409920

Why does fluorosed dentine show a higher susceptibility for caries:An ultra- morphological explanation

Kanchana Waidyasekera,二階堂徹,Dinesh Weerasinghe,Watanabe Akihiko,市野瀬志津子,Franklin Tay,田上順次
Journal of Medical and Dental Sciences 57(1), 17-23, 2010
… Background-Chronic endemic dental fluorosis is amalformation of teeth caused by excessiveingestion of fluoride during period of toothdevelopment. …
NAID 110007544680