end-stage renal disease

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ESRD
kidney diseasechronic

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/04/28 16:01:04」(JST)

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英文文献

  • A8.32 Regulatory B-cell supress T-cell proliferation through a TGFβ/IDO axis and are deficient in chronic humoral rejection.
  • Nouel A, Segalen I, Jamin C, Pers JO, Le Meur Y, Hillion S.Author information Immunology, EA2216, Brest, France.AbstractIn kidney transplantation, B cell is increasingly identified as an important determinant for graft outcome. Chronic antibody mediated rejection (cABMR) represent today the major complication in clinic. Patients with cABMR display a unique B cell phenotype characterised by a disturbance in B cell distribution. Here, the aim of our study was to research if cABMR B cells present also impaired regulatories functions. Experiments are realised in 12 stable patients (ST) (delay from graft >12 months, no rejection, proteinuria <0.5g/24h, PRA <10%, no DSA and a one year biopsy without allograft glomerulopathy or rejection), 14 patients with cABMR (positive DSA, allograft glomerulopathy and/or C4d staining) and 17 controls (blood donors). B-cell functions were analysed using coculture with B and T cells. Proliferation and Th1 cytokine secretion of isolated CFSE labelled T cells in presence of autologous B cells was compared between the 3 groups. T cells were stimulated with anti CD3 and anti CD28, and co-cultured with CpG-activated B cells. Suppressive cytokines like TGFβ and IL-10 and the regulatory enzyme indoleamine 2,3-dioxygenase (IDO) were evaluated during the course of the culture. First, we have demonstrated that compared with situation of stable graft function and healthy volunteers, B cells from cABMR patients display an impaired regulatory function on T cell proliferation and Th1 production. Furthermore, B cells induce more T regulatory cells (Tregs) in coculture after 4 days in HV and ST groups compared to cABMR group (p<10(-3)). We also evidenced that TGFβ and IDO expressed by B cells are involved in inhibition of T cell proliferation and Treg cells generation in HV and ST patients. We additionally shown that B cells from cABMR patients present a failure of TGFβ and IL-10 secretion in co-culture associated with a significantly decrease of IDO production leading to a defect in the capacity of activated-B cells to induce Treg cells and control T cell responses. Finally, B cells from cABMR patients display functional abnormalities as evidenced by the loss of B cell suppressive activity. This work represents interesting perspectives with the discovered of new cellular targets who can be might guide therapy in transplantation in the future.
  • Annals of the rheumatic diseases.Ann Rheum Dis.2014 Mar 1;73 Suppl 1:A89. doi: 10.1136/annrheumdis-2013-205124.206.
  • In kidney transplantation, B cell is increasingly identified as an important determinant for graft outcome. Chronic antibody mediated rejection (cABMR) represent today the major complication in clinic. Patients with cABMR display a unique B cell phenotype characterised by a disturbance in B cell dis
  • PMID 24489337
  • A8.31 Characterisation of human transitional B-cells though their regulatory functions.
  • Hillion S, Simon Q, Jamin C, Renaudineau Y, Pers JO.Author information Immunology and Immunotherapy, CHRU Morvan, Brest, France.AbstractTransitional B cells represent a cortical link between the initial B cell compartment in bone marrow and the mature peripheral B cell repertoire. The prior characterisation of human transitional B-cells has suggested that this population could be subdivised into two major subsets: the immature T1-Bcells CD19(+) CD10high CD24high CD38high IgMhigh IgDlow CD21low and tne intermediate cells mentionned as T2-B cells CD19(+) CD10 + CD24high CD38high IgMhigh IgDhigh CD21high. Recently B-cell regulation have been shed in light and a lot of evidences suggested that regulatory B cells (Bregs) are contained within the CD24high CD38high transitional B-cell subsets. In this study, we wanted to fully characterised the composition of the CD24high CD38high population using phenotypic and functionnal approaches. First, we used a non manual and non subjective gating technique with 10 color flow cytometry to identify the different subsets contained in the CD24high CD38high population through FLOCK (Flow cytometry without K) algorythm program. We showed that non less than 5 different populations are present in the parent gate. Three population are included in transitional B-cell subset confirmed by in vitro functional analysis. The two other populations belong to memory B-cells. In the second part of the work, the different populations were sorted and their supressive capacities in a coculture model of B cells and activated T-cell were analysed. We demonstrated that B-cell subets have different regulatory potency on the inhibition of T-cell proliferation and Th1 cytokine production. These data bring new clarifications on the precise nature of regulatory B cells in human and their supressive functions. Regulatory B-cell supress T-cell proliferation through a TGFβ/IDO axis and are deficient in chronic humoral rejection In kidney transplantation, B cell is increasingly identified as an important determinant for graft outcome. Chronic antibody mediated rejection (cABMR) represent today the major complication in clinic. Patients with cABMR display a unique B cell phenotype characterised by a disturbance in B cell distribution. Here, the aim of our study was to research if cABMR B cells present also impaired regulatories functions. Experiments are realised in 12 stable patients (ST) (delay from graft >12 months, no rejection, proteinuria <0.5g/24h, PRA <10%, no DSA and a one year biopsy without allograft glomerulopathy or rejection), 14 patients with cABMR (positive DSA, allograft glomerulopathy and/or C4d staining) and 17 controls (blood donors). B-cell functions were analysed using coculture with B and T cells. Proliferation and Th1 cytokine secretion of isolated CFSE labelled T cells in presence of autologous B cells was compared between the 3 groups. T cells were stimulated with anti CD3 and anti CD28, and co-cultured with CpG-activated B cells. Suppressive cytokines like TGFβ and IL-10 and the regulatory enzyme indoleamine 2,3-dioxygenase (IDO) were evaluated during the course of the culture. First, we have demonstrated that compared with situation of stable graft function and healthy volunteers, B cells from cABMR patients display an impaired regulatory function on T cell proliferation and Th1 production. Furthermore, B cells induce more T regulatory cells (Tregs) in coculture after 4 days in HV and ST groups compared to cABMR group (p<10(-3)). We also evidenced that TGFβ and IDO expressed by B cells are involved in inhibition of T cell proliferation and Treg cells generation in HV and ST patients. We additionally shown that B cells from cABMR patients present a failure of TGFβ and IL-10 secretion in co-culture associated with a significantly decrease of IDO production leading to a defect in the capacity of activated-B cells to induce Treg cells and control T cell responses. Finally, B cells from cABMR patients display functional abnormalities as evidenced by the loss of B cell suppressive activity. This work represents interesting perspectives with the discovered of new cellular targets who can be might guide therapy in transplantation in the future.
  • Annals of the rheumatic diseases.Ann Rheum Dis.2014 Mar 1;73 Suppl 1:A88-9. doi: 10.1136/annrheumdis-2013-205124.205.
  • Transitional B cells represent a cortical link between the initial B cell compartment in bone marrow and the mature peripheral B cell repertoire. The prior characterisation of human transitional B-cells has suggested that this population could be subdivised into two major subsets: the immature T1-Bc
  • PMID 24489336
  • Differences in the clinical presentation and the frequency of complications between elderly and non-elderly scrub typhus patients.
  • Jang MO1, Kim JE1, Kim UJ1, Ahn JH1, Kang SJ1, Jang HC1, Jung SI1, Park KH2.Author information 1Department of Internal Medicine, Chonnam National University Hospital, Gwang-ju, Republic of Korea.2Department of Internal Medicine, Chonnam National University Hospital, Gwang-ju, Republic of Korea. Electronic address: iammedkid@naver.com.AbstractAge can affect the clinical features and severity of infectious disorders, such as scrub typhus. We performed this study to examine differences between elderly and non-elderly scrub typhus patients, and to identify risk factors predictive of disease outcomes. This retrospective study included patients admitted to a tertiary hospital with scrub typhus between 2001 and 2011. A total of 615 patients were enrolled in this study, 328 of which were >65 years of age. Of the elderly patients, 46.0% (151/328) experienced at least one complication compared to only 23.0% (66/287) in younger patients. A linear trend was observed between age and complication rates (p=0.002). The most common complication in elderly patients was acute kidney injury (75, 22.9%). Treatment failure was reported in 10 elderly patients (3.0%) compared to one non-elderly patient (0.3%). Mental confusion and dyspnea of clinical manifestations at admission were common in elderly patients. Frequency of fever, rash, and eschar were similar in both groups. The following four factors were significantly associated with severe scrub typhus in elderly patients: (1) white blood cell (WBC) counts>10,000/mm(3) (OR=2.569, CI=1.298-5.086), (2) MDRD GFR<60mL/min (OR=3.525, CI=1.864-6.667), (3) albumin≤3.0g/dL (OR=4.976, CI=2.664-9.294), and (4) acute physiology and chronic health evaluation II (APACHE II) score>10 points (OR=3.304, CI=1.793-60.87). Complications and mortality were more common in elderly patients, often associated with delays in diagnosis and treatment.
  • Archives of gerontology and geriatrics.Arch Gerontol Geriatr.2014 Mar-Apr;58(2):196-200. doi: 10.1016/j.archger.2013.10.011. Epub 2013 Nov 2.
  • Age can affect the clinical features and severity of infectious disorders, such as scrub typhus. We performed this study to examine differences between elderly and non-elderly scrub typhus patients, and to identify risk factors predictive of disease outcomes. This retrospective study included patien
  • PMID 24268946

和文文献

  • サルコイドーシスを原疾患とする慢性腎不全に対して生体腎移植を施行した1例
  • 武田 将司,小林 恭,住吉 真治 [他]
  • 泌尿器科紀要 = Acta urologica Japonica 60(7), 319-322, 2014-07
  • NAID 40020132836
  • Significant Decrease in Plasma N-Acetyl-seryl-aspartyl-lysyl-proline Level in Patients with End Stage Renal Disease after Kidney Transplantation
  • Suzuki Yosuke,Katagiri Fumihiko,Sato Fuminori [他]
  • Biological & pharmaceutical bulletin 37(6), 1075-1079, 2014-06
  • NAID 40020073715
  • 導入免疫抑制剤投与により生体腎移植当日に無顆粒球症をきたした慢性腎不全の1例
  • 松本 敬優,小林 恭,村上 薫,大久保 和俊,根来 宏光,寺田 直樹,杉野 善雄,山﨑 俊成,松井 喜之,井上 貴博,神波 大己,吉村 耕治,小川修
  • 泌尿器科紀要 = Acta urologica Japonica 60(6), 275-278, 2014-06
  • … A 20-year-old man with end-stage renal disease was scheduled to have an ABO-incompatible living kidney transplantation donated by his mother. …
  • NAID 120005456037

関連リンク

End-Stage Renal Disease By Jason Klein BMB Seminar May 3, 1999 Outline I. Kidney: Basic structure and function II. Scope of the Problem III. Causes of End-Stage Renal Disease IV. Metabolic consequences of End-Stage ...
End Stage Renal Disease (ESRD) Advance Care Planning Tool RPA developed this tool to facilitate advance care planning for CKD and ESRD patients. ESRD Guidelines Clinical Practice Guideline on Shared Decision Making in ...

関連画像

Treatment for ESRD (End Stage Renal 2006 Jazz Communications LTD, Used with end stage renal disease Car TuningEnd Stage Renal Disease Treatment, End  year old man with end stage renal diseaseend stage renal disease network


★リンクテーブル★
リンク元chronic kidney failure」「ESRD」「end-stage renal failure」「末期腎不全
拡張検索diabetic end-stage renal disease
関連記事end」「stage」「disease」「ending」「stag

chronic kidney failure」

  [★]

慢性腎不全

chronic renal failurechronic renal insufficiencyend-stage kidney diseaseend-stage renal diseaseend-stage renal failureESRD


ESRD」

  [★]

chronic kidney failurechronic renal failureend-stage kidney diseaseend-stage renal diseaseend-stage renal failure


end-stage renal failure」

  [★]

末期腎不全

chronic kidney failurechronic renal failureend-stage kidney diseaseend-stage renal diseaseESRD


末期腎不全」

  [★]

end-stage renal diseaseend-stage renal failureESRD
慢性腎不全末期腎疾患



diabetic end-stage renal disease」

  [★]

糖尿病性末期腎疾患糖尿病末期腎不全


end」

  [★]

  • n.
  • v.
aimbrinkceasecompleteconcludecornerdistaleventuateextremitygoalobjectobjectivesideterminalterminallyterminatetermination

WordNet   license wordnet

「put an end to; "The terrible news ended our hopes that he had survived"」

WordNet   license wordnet

「a final state; "he came to a bad end"; "the so-called glorious experiment came to an inglorious end"」
destruction, death

WordNet   license wordnet

「the point in time at which something ends; "the end of the year"; "the ending of warranty period"」
ending

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「bring to an end or halt; "She ended their friendship when she found out that he had once been convicted of a crime"; "The attack on Poland terminated the relatively peaceful period after WW I"」
terminate

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「a piece of cloth that is left over after the rest has been used or sold」
remainder, remnant, oddment

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「(American football) a position on the line of scrimmage; "no one wanted to play end"」

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「the part you are expected to play; "he held up his end"」

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「the concluding parts of an event or occurrence; "the end was exciting"; "I had to miss the last of the movie"」
last, final stage

WordNet   license wordnet

「either extremity of something that has length; "the end of the pier"; "she knotted the end of the thread"; "they rode to the end of the line"; "the terminals of the anterior arches of the fornix"」
terminal

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「(football) the person who plays at one end of the line of scrimmage; "the end managed to hold onto the pass"」

WordNet   license wordnet

「a boundary marking the extremities of something; "the end of town"」

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「a final part or section; "we have given it at the end of the section since it involves the calculus"; "Start at the beginning and go on until you come to the end"」

WordNet   license wordnet

「one of two places from which people are communicating to each other; "the phone rang at the other end"; "both ends wrote at the same time"」

WordNet   license wordnet

「the surface at either extremity of a three-dimensional object; "one end of the box was marked `This side up''"」

PrepTutorEJDIC   license prepejdic

「(細いものの)『端』,先端《+『of』+『名』》 / (物語などの)『終り』,終結部《+『of』+『名』》 / (物事・期間の)『最後』《+『of』+『名』》;(…に)結末をつけるもの《+『to』+『名』》 / (…の)端の部分,末端部《『of』+『名』》 / 《しばしば複数形で》『目的』(purpose),目標(aim) / 《遠回しに》死,滅亡 / 《しばしば複数形で》切れ端,くず,残りもの / (事業などの)部門(part) / (フットボールで)エンド)前衛両端の選手または位置) / …‘を'『終わらせる』,終える / 〈物事が〉…‘の'終りとなる,‘を'締めくくる / 『終わる』,終了する(come to an end)」

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「have an end, in a temporal, spatial, or quantitative sense; either spatial or metaphorical; "the bronchioles terminate in a capillary bed"; "Your rights stop where you infringe upon the rights of other"; "My property ends by the bushes"; "The symphony ends in a pianissimo"」
stop, finish, terminate, cease

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「be the end of; be the last or concluding part of; "This sad scene ended the movie"」
terminate


stage」

  [★]

  • n.
gradeperiodphasesteptime

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「perform (a play), especially on a stage; "we are going to stage `Othello''"」
present, represent

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「any scene regarded as a setting for exhibiting or doing something; "All the world''s a stage"--Shakespeare; "it set the stage for peaceful negotiations"」

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「the theater as a profession (usually `the stage'」

PrepTutorEJDIC   license prepejdic

「(劇場・ホールなどの)『舞台』・on stage 舞台上で・《無冠詞》・off stage 舞台の陰で 《無冠詞》:ステージ;演壇;《the~》演劇;俳優業,演劇(舞台)の仕事 / (事件・活動などの)『舞台』,場所 / (発達などの)『段階』,時期 / (駅馬車などの止まる)駅,宿場;休憩地;(旅行における休憩地間の)旅程,行程 / =stagecoach / (多段ロケットの)段 / 〈劇〉‘を'『上演する』,〈試合など〉‘を'公開する / (特に劇的に)…‘を'実行する,やってのける」

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「a section or portion of a journey or course; "then we embarked on the second stage of our Caribbean cruise"」
leg

WordNet   license wordnet

「a small platform on a microscope where the specimen is mounted for examination」
microscope stage

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「a large platform on which people can stand and can be seen by an audience; "he clambered up onto the stage and got the actors to help him into the box"」

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「plan, organize, and carry out (an event); "the neighboring tribe staged an invasion"」
arrange


disease」

  [★]

  • n.
疾患illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)
特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)
  • something that is very wrong with people's attitudes, way of life or with society.
ailailmentdisease entitydisorderillillnessmaladysicksickness
  • 注意
diseaseillnessdisorder


WordNet   license wordnet

「an impairment of health or a condition of abnormal functioning」

PrepTutorEJDIC   license prepejdic

「(体の)『病気』,疾患 / (精神・道徳などの)病気,病弊」

PrepTutorEJDIC   license prepejdic

「女性の話術芸人 =diseur」


ending」

  [★]

  • n.
terminalterminally

WordNet   license wordnet

「event whose occurrence ends something; "his death marked the ending of an era"; "when these final episodes are broadcast it will be the finish of the show"」
conclusion, finish

WordNet   license wordnet

「the end of a word (a suffix or inflectional ending or final morpheme); "I don''t like words that have -ism as an ending"」
termination

PrepTutorEJDIC   license prepejdic

「終り,終了;(物語・映画などの)結末 / (文の)語尾」


stag」

  [★]

WordNet   license wordnet

「attend a dance or a party without a female companion」

PrepTutorEJDIC   license prepejdic

「雄ジカ / 《米話》(社交的な集まりに)婦人を同伴しない男 / 男性用の,男性のみ出席する,男性向けの / 女性を同謀しないで」

WordNet   license wordnet

「adult male deer」




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