eicosanoids

出典: meddic

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/08 08:16:11」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

英文文献

  • Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies.
  • Record M, Carayon K, Poirot M, Silvente-Poirot S.Author information INSERM-UMR 1037, Cancer Research Center of Toulouse (CRCT), Team "Sterol Metabolism and Therapeutic Innovation in Oncology", BP3028, CHU Purpan, Toulouse F-31300, France; Institut Claudius Regaud, 20-24 Rue du Pont Saint-Pierre, 31052 Toulouse Cedex, France; Université Paul Sabatier Toulouse 3, 118 Route de Narbonne, Toulouse, France. Electronic address: michel.record@inserm.fr.AbstractExosomes are nanovesicles that have emerged as a new intercellular communication system between an intracellular compartment of a donor cell towards the periphery or an internal compartment of a recipient cell. The bioactivity of exosomes resides not only in their protein and RNA contents but also in their lipidic molecules. Exosomes display original lipids organized in a bilayer membrane and along with the lipid carriers such as fatty acid binding proteins that they contain, exosomes transport bioactive lipids. Exosomes can vectorize lipids such as eicosanoids, fatty acids, and cholesterol, and their lipid composition can be modified by in-vitro manipulation. They also contain lipid related enzymes so that they can constitute an autonomous unit of production of various bioactive lipids. Exosomes can circulate between proximal or distal cells and their fate can be regulated in part by lipidic molecules. Compared to their parental cells, exosomes are enriched in cholesterol and sphingomyelin and their accumulation in cells might modulate recipient cell homeostasis. Exosome release from cells appears to be a general biological process. They have been reported in all biological fluids from which they can be recovered and can be monitors of specific pathophysiological situations. Thus, the lipid content of circulating exosomes could be useful biomarkers of lipid related diseases. Since the first lipid analysis of exosomes ten years ago detailed knowledge of exosomal lipids has accumulated. The role of lipids in exosome fate and bioactivity and how they constitute an additional lipid transport system are considered in this review.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jan;1841(1):108-20. doi: 10.1016/j.bbalip.2013.10.004. Epub 2013 Oct 16.
  • Exosomes are nanovesicles that have emerged as a new intercellular communication system between an intracellular compartment of a donor cell towards the periphery or an internal compartment of a recipient cell. The bioactivity of exosomes resides not only in their protein and RNA contents but also i
  • PMID 24140720
  • A phospholipase A2 gene is linked to Jack bean urease toxicity in the Chagas' disease vector Rhodnius prolixus.
  • Defferrari MS, Lee DH, Fernandes CL, Orchard I, Carlini CR.Author information Graduate Program in Cellular and Molecular Biology, Center of Biotechnology, Institute of Biosciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: marina.defferrari@ufrgs.br.AbstractBACKGROUND: Ureases are multifunctional enzymes that display biological activities independent of their enzymatic function, including exocytosis induction and insecticidal effects. The hemipteran Rhodnius prolixus is one of the known susceptible models for this toxicity. It has been shown that Jack bean urease (JBU) has deleterious effects on R. prolixus, and these effects are modulated by eicosanoids, which are synthesized in a cascade involving phospholipase A2 (PLA2) enzymes.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jan;1840(1):396-405. doi: 10.1016/j.bbagen.2013.09.016. Epub 2013 Sep 18.
  • BACKGROUND: Ureases are multifunctional enzymes that display biological activities independent of their enzymatic function, including exocytosis induction and insecticidal effects. The hemipteran Rhodnius prolixus is one of the known susceptible models for this toxicity. It has been shown that Jack
  • PMID 24055375

和文文献

  • 脂質由来メディエーターの種類・構造と生体での役割
  • 横溝 岳彦
  • 内分泌・糖尿病・代謝内科 36(6), 540-547, 2013-06
  • NAID 40019739302
  • 呼吸不全 (特集 高齢者の救急医療 : その病態特徴と基本管理) -- (高齢者内因性の救急疾患と処置)

関連リンク

脂肪酸代謝では、炭素数20の脂肪酸で二重結合を4個もつアラキドン酸と、二重結合を5個もつエイコサペンタエン酸(EPA)からさまざまな生理活性物質が生成されてくる。この生理活性物質をエイコサノイド(eicosanoids)と呼び ...
eicosanoids a family of compounds derived from arachidonic acid (eicosatetraenoic acid). Includes prostaglandins, prostacyclin and thromboxanes, the principal mediators of inflammation. ei·co·sa·noids (ī'kō-să-noydz), The ...

関連画像

Figure 2 Synthesis of eicosanoids from drugs acting on eicosanoids of Eicosanoids in T Cells | T Cell BiologyEicosanoids & Vascular Pharmacology



★コメント★

[メモ入力エリア]
※コメント5000文字まで
ニックネーム:
コメント:




表示
個人用ツール


  meddic.jp

リンク
連絡
週間・日々の人気記事
最近7日間の人気記事
 タイトル表示
1マーフィー徴候 18
2narrow segment 16
3" wounds are made"  15
4グレイ症候群 15
5"phenoxypolyethoxylethanol" 15
6ロイシンエンケファリン 13
7硝酸ミコナゾール 11
8Common Laboratory Equipment 11
9content 10
10だいすいたいしんけい 9
11粟粒結核と肉下種 9
12全身性ヒマン細胞小 9
13細胞内寄生菌 9
14kligler培地 原理 9
15不整脈  9
16角膜反射 中枢 9
17膜性骨化 8
18ソルデム 8
19ハプロ不全 疾患 8
20日本多毛 8

昨日の人気記事
 タイトル表示
1" wounds are made"  15
2kligler培地 原理 9
3kligler培地 硫化鉄 4
4ǸCαꥦ륹ΤǤ뤳ȤŦƤ֤Ƥ 4
5歳の女性。右目の疼痛、充血および霧視を主訴に来院した。眼底に異常を認めない。視力は右 0.9 (矯正不能)、左 1.2 (矯正不能)。眼圧は右 11 mmHg、左 12 mmHg。フルオレセイン染色後の前眼部写真 (別冊No. 5) を別に示す。 治療薬として適切なのはどれか。 4
6胃癌 borrmann分類 3
7回復過程 3
8ジェンドラシック法 メカニズム 3
9しょうすいたいしんけい 3
10ラリンゲルマスク ゼリー 3
11ハッセルバッハ三角 3
12白内障 grade 3
13フォンギールケ病 3
14マッコーネルサイン 3
15小児骨折 好発部位 3
16咽頭神経叢 3
17低アルドステロン症 3
18フロマン徴候 3
19オーグメンチン 販売中止 3
20クスマウル徴候 3