efflux pumps

WordNet

1. supply in great quantities; "Pump money into a project"
2. a low-cut shoe without fastenings
3. a mechanical device that moves fluid or gas by pressure or suction
4. deliver forth; "pump bullets into the dummy"
5. draw or pour with a pump
6. flow intermittently
7. move up and down; "The athlete pumps weights in the gym"
8. operate like a pump; move up and down, like a handle or a pedal; "pump the gas pedal"
9. question persistently; "She pumped the witnesses for information"
10. raise (gases or fluids) with a pump

PrepTutorEJDIC

1. 『ポンプ』 / 《単数形で》ポンプで空気(ガス)を入れること / 《副詞[句]を伴って》〈気体・液体〉‘を'『ポンプで入れる』(『出す』) / …‘から'ポンプで水(など)を除く《+『out』+『名』,+『名』+『out』》 / …‘に'ポンプで空気(など)を満たす《+『up』+『名』,+『名』+『up』》 / (ポンプのハンドルのように)…‘を'上下(前後)に動かす / 《話》(…について)〈人〉‘を'あの手この手で問いただす(聞き出す)《+『名』+『for』(『about』)+『名』》 / 《話》(人に)〈知識など〉‘を'詰め込む《+『名』+『into』+『名』〈人〉》;(人から)〈情報など〉‘を'引き出す《+『名』+『out of』+『名』〈人〉》 / ポンプを使う / (ポンプのように)上下に動く,鼓動する / 〈水が〉噴出する
2. パンプス(ひもや金具がなく,甲のあいた靴)
3. (ガス・液体の)流出 / 流出物

UpToDate Contents

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• 1. HDLコレステロール：異常値の臨床的側面 hdl cholesterol clinical aspects of abnormal values
• 2. アシネトバクター感染：治療および予防 acinetobacter infection treatment and prevention
• 3. テトラサイクリン tetracyclines
• 4. アジスロマイシン、クラリスロマイシン、およびテリスロマイシン azithromycin clarithromycin and telithromycin
• 5. ステノトロフォモナス・マルトフィリア stenotrophomonas maltophilia

English Journal

• Mechanisms of antimicrobial resistance in Gram-negative bacilli.

• Ruppé É1, Woerther PL, Barbier F.
• Annals of intensive care.Ann Intensive Care.2015 Dec;5(1):61. doi: 10.1186/s13613-015-0061-0. Epub 2015 Aug 12.
• The burden of multidrug resistance in Gram-negative bacilli (GNB) now represents a daily issue for the management of antimicrobial therapy in intensive care unit (ICU) patients. In Enterobacteriaceae, the dramatic increase in the rates of resistance to third-generation cephalosporins mainly results
• PMID 26261001

• Prevalence and proliferation of antibiotic resistance genes in two municipal wastewater treatment plants.

• Mao D1, Yu S2, Rysz M3, Luo Y4, Yang F5, Li F2, Hou J2, Mu Q2, Alvarez PJ6.
• Water research.Water Res.2015 Nov 15;85:458-66. doi: 10.1016/j.watres.2015.09.010. Epub 2015 Sep 7.
• The propagation of antibiotic resistance genes (ARGs) is an emerging health concern worldwide. Thus, it is important to understand and mitigate their occurrence in different systems. In this study, 30 ARGs that confer resistance to tetracyclines, sulfonamides, quinolones or macrolides were detected
• PMID 26372743

• Mutation of Rv2887, a marR-Like Gene, Confers Mycobacterium tuberculosis Resistance to an Imidazopyridine-Based Agent.

• Winglee K1, Lun S1, Pieroni M2, Kozikowski A3, Bishai W4.
• Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2015 Nov;59(11):6873-81. doi: 10.1128/AAC.01341-15. Epub 2015 Aug 24.
• Drug resistance is a major problem in Mycobacterium tuberculosis control, and it is critical to identify novel drug targets and new antimycobacterial compounds. We have previously identified an imidazo[1,2-a]pyridine-4-carbonitrile-based agent, MP-III-71, with strong activity against M. tuberculosis
• PMID 26303802

Japanese Journal

• Roles of Multidrug Efflux Pumps on the Biofilm Formation of Escherichia coli K-12

• MATSUMURA KAYO,FURUKAWA SOICHI,OGIHARA HIROKAZU,MORINAGA YASUSHI
• Biocontrol Science 16(2), 69-72, 2011
• … We genetically analyzed the roles of multidrug efflux pumps on the biofilm formation of Escherichia coli K-12 BW25113. … We used 22 mutants missing various genes related to the multidrug efflux pumps and found that the biofilm formation of emrD, emrE, emrK, acrD, acre and mdtE-deleted mutants was extremely decreased. …
• NAID 130000723588

Related Links

• importance of efflux pumps in bacterial antibiotic resistance

All bacterial genomes studied contain several different efflux pumps; this indicates their ancestral origins. It has been estimated that ∼5–10% of all bacterial genes are involved in transport and a large proportion of these encode 2, 4

• Multidrug efflux pumps: structure, function and regulation

In this Review, we summarize our current understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria. We discuss their regulation by two-component systems (TCSs ...

• Introduction: Transporters, Porins, and Efflux Pumps

This thematic issue of Chemical Reviews, “Transporters, Porins, and Efflux Pumps”, is focused on the function of biological membranes as a permeability barrier and on the proteins that create, maintain, and bypass this barrier. Effective therapeutic interventions rely on active and passive permeation of various molecules and compounds ...

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関連記事	「efflux」「pump」「pumping」

「efflux」

　　[★]

• n.

• 流出、外向き電流

• v.

• 流出する

関

discharge、outflow、outward current、runoff

　

「pump」

　　[★]

• n.

• ポンプ

• v.

• ポンピングする

関

pumping

　 　 　 　 　 　 　 　 　 　 　 　

「pumping」

　　[★]

• n.

• パンピング、ポンピング

関

pump