有効性の分析、有効性の解析

WordNet

an investigation of the component parts of a whole and their relations in making up the whole
the abstract separation of a whole into its constituent parts in order to study the parts and their relations (同)analytic thinking
a branch of mathematics involving calculus and the theory of limits; sequences and series and integration and differentiation
a form of literary criticism in which the structure of a piece of writing is analyzed
the use of closed-class words instead of inflections: e.g., `the father of the bride instead of `the brides father
capacity or power to produce a desired effect; "concern about the safety and efficacy of the vaccine" (同)efficaciousness

PrepTutorEJDIC

(内容・状況などの)『分析』,分解;(詳細な)検討 / (化学・物理で)分析;《米》(心理学で)[精神]分析;(数学で)解析
(…に対する,における)効きめ,効力《+『against』(『in』)+『名』》

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1. 費用対効果分析入門 a short primer on cost effectiveness analysis
2. 成人におけるクローン病治療のためのナタリズマブ natalizumab for treatment of crohn disease in adults
3. 切除可能非小細胞肺癌における全身補助化学療法 adjuvant systemic therapy in resectable non small cell lung cancer
4. うつ病の成人に対する対人関係療法（IPT）：適応、理論基盤、一般概念と有効性 interpersonal psychotherapy ipt for depressed adults indications theoretical foundation general concepts and efficacy
5. 不整脈の評価およびマネージメントにおける加算平均心電図の利用 use of the signal averaged electrocardiogram in arrhythmia evaluation and management

English Journal

Confirmed efficacy of topical nifedipine in the treatment of facial wrinkles.

Calabrò G, De Vita V, Patalano A, Mazzella C, Lo Conte V, Antropoli C.Author information Department of Dermatology, University of Naples Federico II , Naples , Italy.AbstractIntroduction: Over the past two decades, there has been increasing demand for aesthetic procedures to reverse the effects of aging, particularly in the facial area. Recently, topical nifedipine has been proposed for its anti-wrinkle efficacy. Objective: To confirm the anti-wrinkle efficacy of a 0.5% nifedipine-based topical formulation. Materials and methods: A randomized study was conducted in 20 healthy female volunteers, aged between 45 and 60 years, with moderate to moderately severe facial wrinkles. 10 volunteers applied a 0.5% nifedipine cream and 10 volunteers applied a good moisturizer twice daily for 90 days. The aesthetic improvement was evaluated by a blinded investigator using the Wrinkle Severity Rating Scale (WSRS). Anti-wrinkles effectiveness was also objectively assessed by measuring transepidermal water loss (TEWL), moisture levels of the stratum corneum, skin viscoelasticity and skin folding capacity by instrumental analysis. Results: Post-treatment WSRS score was significantly lower than the baseline WSRS score only in the nifedipine group. The mean WSRS score at T0 was 3.85 and at T3 1.84 in the nifedipine group, while the mean WSRS score at T0 was 3.78 and at T3 3.36 in the control group. Corneometry showed significant increases in measures of skin hydration and TEWL values decreased in all the patients of both groups, indicating a trend toward improved integrity of skin. Dermolab® recorded significant increases in measures of skin hydration in the nifedipine group and a lower increase in the control group. The colorimetric evaluation showed that use of the tested product resulted in significant overall lightening of the skin during use compared with baseline, while the moisturizer didn't produce any change of skin lightening parameters. Conclusion: The tested topical preparation is effective in reducing facial wrinkles' depth and in increasing skin hydration and elasticity.
The Journal of dermatological treatment.J Dermatolog Treat.2014 Aug;25(4):319-25. doi: 10.3109/09546634.2013.802759. Epub 2013 Jun 2.
Introduction: Over the past two decades, there has been increasing demand for aesthetic procedures to reverse the effects of aging, particularly in the facial area. Recently, topical nifedipine has been proposed for its anti-wrinkle efficacy. Objective: To confirm the anti-wrinkle efficacy of a 0.5%
PMID 23688162

Physicochemical and structural characterization of iron-sucrose formulations: a comparative study.

Barot BS, Parejiya PB, Mehta DM, Shelat PK, Shah GB.Author information Department of Pharmaceutics, K.B. Institute of Pharmaceutical Education and Research , Kadi Sarva Vishwavidyalaya, Gandhinagar , India.AbstractAbstract Intravenous polynuclear iron formulations are vital components in the treatment of iron deficiency anemia associated with chronic kidney disease as well as other diseases associated with gastro-intestinal and cardio-vascular system. Intravenous iron preparations consist of iron-carbohydrate nanoparticles with iron-oxyhydroxide as a core covered by carbohydrate shell. These preparations should be very well characterized in terms of their physicochemical properties and pharmacological profile in order to establish safety and efficacy. The present research work was aimed to physicochemically characterize a new generic iron-sucrose preparation (IS-Claris) and establish its equivalency with the reference product (Venofer®). Various analytical techniques including gel permeation chromatography (GPC), mass spectroscopy (MALDI-TOF), absorption spectroscopy, X-ray diffraction analysis (XRD), nuclear magnetic resonance spectroscopy (proton and (13)C NMR), Fourier transform infrared spectroscopy (FTIR) and thermal gravimetric analysis (TGA) were employed. It was observed that the specifications of IS-Claris obtained through these analyses reflect those of Venofer® and hence the two formulations were considered comparable.
Pharmaceutical development and technology.Pharm Dev Technol.2014 Aug;19(5):513-20. doi: 10.3109/10837450.2013.795171. Epub 2013 May 24.
Abstract Intravenous polynuclear iron formulations are vital components in the treatment of iron deficiency anemia associated with chronic kidney disease as well as other diseases associated with gastro-intestinal and cardio-vascular system. Intravenous iron preparations consist of iron-carbohydrate
PMID 23701359

Assessing therapeutic effectiveness of scalp treatments for dandruff and seborrheic dermatitis, part 2: the impact of gender and ethnicity on efficacy.

Bacon RA, Mizoguchi H, Schwartz JR.Author information The Procter and Gamble Company , Cincinnati, OH , USA.AbstractBackground: Dandruff and seborrheic dermatitis (D/SD) are common and troublesome scalp conditions that affect individuals independent of gender or ethnicity. Aim: To evaluate whether population gender or ethnic origins impact the magnitude of anti-dandruff therapeutic benefit obtained from use of a potentiated zinc pyrithione shampoo treatment. Methods: A retrospective evaluation of anti-dandruff clinical data covering a single-product technology was conducted to assess whether statistically meaningful differences were observed for gender or ethnic sub-populations. An analysis of covariance was performed on the pooled subject-level data. Results: Meta-analysis of clinical data involving 1114 subjects from seven trials demonstrated the lack of statistically significant impact of gender on flaking or selected biomarker measures. Similarly, a smaller population chosen to assess ethnicity demonstrated the lack of differences between Asian and Caucasian clinical sub-population responses (flaking severity). Conclusion: Through the use of both expert symptom grading and objective biomarker assessments, therapeutic efficacy of a potentiated zinc pyrithione shampoo was found to be independent of gender and ethnicity, being consistent with the lack of functional differences in skin from these populations.
The Journal of dermatological treatment.J Dermatolog Treat.2014 Jun;25(3):237-40. doi: 10.3109/09546634.2012.719077. Epub 2012 Sep 19.
Background: Dandruff and seborrheic dermatitis (D/SD) are common and troublesome scalp conditions that affect individuals independent of gender or ethnicity. Aim: To evaluate whether population gender or ethnic origins impact the magnitude of anti-dandruff therapeutic benefit obtained from use of a
PMID 22866664

Japanese Journal

幼児期の箸の操作方法に関する臨床的検討(第2報)支援方法の効果について

大岡貴史,板子絵美,飯田光雄
小児保健研究 = The journal of child health 72(1), 28-34, 2013-01
NAID 40019559908

Efficacy and safety of aripiprazole in patients with acute manic or mixed episodes of bipolar ？ disorder : Treatment response in subgroup and detailed analysis of side effects

堀輝,中村純,神庭重信
臨床精神医学 42(1), 107-117, 2013-01
NAID 40019550322

Usefulness of fluorine-18 fluorodeoxyglucose-positron emission tomography in management strategy for thymic epithelial tumors

Matsumoto Isao,Oda Makoto,Takizawa Masaya,Waseda Ryuichi,Nakajima Kenichi,Kawano Masaya,Mochizuki Takafumi,Ikeda Hiroko,Watanabe Go
Annals of Thoracic Surgery 95(1), 305-310, 2013-01
… SUVmax accurately reflected therapeutic efficacy in patients with induction therapy. … Univariate analysis revealed Masaoka stages III and IV and pathologically incomplete resection as risk factors for relapse. … On multivariate analysis, independent risk factors for relapse comprised only Masaoka stages III and IV. … FDG-PET is also useful for evaluating induction therapy efficacy and detecting relapse. …
NAID 120005223460