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- 1. エンテロウイルスおよびパレコウイルス感染の臨床症状および診断 clinical manifestations and diagnosis of enterovirus and parechovirus infections
- 2. 関節炎の原因となる特定のウイルス specific viruses that cause arthritis
- 3. ウイルス性筋炎 viral myositis
- 4. エンテロウイルスおよびパレコウイルス感染症の疫学、病因、治療、および予防 epidemiology pathogenesis treatment and prevention of enterovirus and parechovirus infections
- 5. 小児における非定型性発疹 atypical exanthems in children
- Recombination and evolutionary dynamics of human echovirus 6.
- Cabrerizo M1, Trallero G, Simmonds P.Author information 1Enterovirus Unit, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.AbstractEnterovirus (EV) infections are associated with a wide array of often severe disease presentations including aseptic meningitis, encephalitis, and acute flaccid paralysis. Surveillance for polioviruses and other EVs is therefore important as a public health measure both for patient management and epidemiological studies. From 1988 to 2008, echovirus (E) 30 was the predominant genotype in Spain (33.7% of the total typed EVs). E6 was also endemic throughout this period although isolated less frequently (12.5%). In 2009, however, a substantial increase in the incidence of E6 was detected (60%), displacing E30 type (2%). To investigate the evolution and recombination in the epidemiology and transmission of E6 in Spain, a genetic analysis in VP1 and 3Dpol regions of 67 Spanish strains collected during the period 2004-2010 was performed. All VP1 sequences clustered monophyletically in the assigned genogroup C, subgroup 9, currently the predominant circulating strains identified in Europe and elsewhere in the last 10 years. 3Dpol sequences were interspersed with other species B EVs resulting from several recombination events that generated at least 12 different recombinant forms (RFs) among study samples. These showed typically minimal divergence in VP1. The co-circulation of different lineages of E6 in the same geographical area associated with its mainly endemic pattern of transmission may have contributed to the extremely short estimated half-life of E6 RFs (0.87 years). This pattern contrasts markedly with other species B EVs and EV71 where VP1 lineage expansion and extinction occurred in step with defined recombination events and periodic changes in incidence.
- Journal of medical virology.J Med Virol.2014 May;86(5):857-64. doi: 10.1002/jmv.23741. Epub 2013 Sep 23.
- Enterovirus (EV) infections are associated with a wide array of often severe disease presentations including aseptic meningitis, encephalitis, and acute flaccid paralysis. Surveillance for polioviruses and other EVs is therefore important as a public health measure both for patient management and ep
- PMID 24114692
- Coxsackievirus A9 Infects Cells via Nonacidic Multivesicular Bodies.
- Huttunen M1, Waris M, Kajander R, Hyypiä T, Marjomäki V.Author information 1Department of Biological and Environmental Science and NanoScience Center, University of Jyväskylä, Jyväskylä, Finland.AbstractCoxsackievirus A9 (CVA9) is a member of the human enterovirus B species in the Enterovirus genus of the family Picornaviridae. According to earlier studies, CVA9 binds to αVβ3 and αVβ6 integrins on the cell surface and utilizes β2-microglobulin, dynamin, and Arf6 for internalization. However, the structures utilized by the virus for internalization and uncoating are less well understood. We show here, based on electron microscopy, that CVA9 is found in multivesicular structures 2 h postinfection (p.i.). A neutral red labeling assay revealed that uncoating occurs mainly around 2 h p.i., while double-stranded RNA is found in the cytoplasm after 3 h p.i. The biogenesis of multivesicular bodies (MVBs) is crucial for promoting infection, as judged by the strong inhibitory effect of the wild-type form of Hrs and dominant negative form of VPS4 in CVA9 infection. CVA9 infection is dependent on phospholipase C at the start of infection, whereas Rac1 is especially important between 1 and 3 h p.i., when the virus is in endosomes. Several lines of evidence implicate that low pH does not play a role in CVA9 infection. The infection is not affected by Bafilomycin A1. In addition, CVA9 is not targeted to acidic late endosomes or lysosomes, and the MVBs accumulating CVA9 have a neutral pH. Thus, CVA9 is the second enterovirus demonstrated so far, after echovirus 1, that can trigger neutral MVBs, which are important for virus infection.
- Journal of virology.J Virol.2014 May;88(9):5138-51. doi: 10.1128/JVI.03275-13. Epub 2014 Feb 26.
- Coxsackievirus A9 (CVA9) is a member of the human enterovirus B species in the Enterovirus genus of the family Picornaviridae. According to earlier studies, CVA9 binds to αVβ3 and αVβ6 integrins on the cell surface and utilizes β2-microglobulin, dynamin, and Arf6 for internalization. However, t
- PMID 24574401
- An outbreak of echovirus 33 in schools in China in 2013.
- Tan X1, Gao L, Ma X, Nie J, Zhan D, Zhang B, Liu Y, Liu F, Xu W.Author information 1Key Laboratory of Medical Virology of Ministry of Health, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.AbstractEchovirus 33 (E33) has been infrequently detected and is less frequently associated with clinical diseases when compared with other types of enteroviruses (EVs) in China. An outbreak of E33 was identified in four schools in Hunan Province, China, in June 2013. For laboratory diagnosis, throat swabs and/or serum specimens were collected from 27 patients. E33 was isolated in cell culture and typed by molecular methods. Complete VP1 gene sequences were determined and analyzed. Specific E33 antibody was measured by virus neutralization testing. From June 3-20, 108 suspected cases were reported, and 19 were confirmed to be associated with E33 by laboratory testing, with seven virologically confirmed and 12 serologically confirmed cases. The suspected cases were in children aged 3-16 years (mean, 11 years), most of whom (94 %, 102/108) were ≥6 years old. The majority of cases (98 %, 106/108) presented as influenza-like illness (ILI), and two were clinically diagnosed as viral meningitis. Older children aged ≥12 years had a higher hospitalization rate (21 %) than younger children (4 %). A BLAST query of GenBank with the Hunan E33 strain VP1 gene sequence gave a close match to an E33 isolate from Pakistan, based on a partial VP1 gene sequence. Phylogenetic analyses of the complete E33 VP1 gene sequences from our study revealed an independent cluster with nucleotide sequences that diverge from E33 from other countries by >12 %. Due to limited E33 VP1 gene sequence data in GenBank and passive EV surveillance in China and most other parts of the world (excepting hand, foot, and mouth disease surveillance in Asia), the approximate origin of Hunan E33 could not be determined.
- Archives of virology.Arch Virol.2014 Apr 3. [Epub ahead of print]
- Echovirus 33 (E33) has been infrequently detected and is less frequently associated with clinical diseases when compared with other types of enteroviruses (EVs) in China. An outbreak of E33 was identified in four schools in Hunan Province, China, in June 2013. For laboratory diagnosis, throat swabs
- PMID 24696270
- Laboratory and Epidemiology Communications : High Incidence of Human Echovirus Type 3 among Children in Osaka, Japan during the Summer of 2010
- Sekiguchi Jun-ichiro,Kubo Hideyuki,Kaida Atsushi [他]
- Japanese Journal of Infectious Diseases 64(6), 533-535, 2011-11
- NAID 40019126201
- Laboratory and epidemiology communications: Endemic transmission of echovirus 30 in Toyama, Japan in 2010 is verified by environmental surveillance
- Iwai Masae,Horimoto Eiji,Obara Mayumi [他]
- Japanese Journal of Infectious Diseases 64(2), 165-167, 2011-03
- NAID 40018775778
- Dahllund L, Nissinen L, Pulli T, Hyttinen VP, Stanway G, Hyypiä T. The genome of echovirus 11. Virus Res. 1995 Feb. 35(2):215-22. [Medline]. Khetsuriani N, Lamonte-Fowlkes A, Oberst S, Pallansch MA. Enterovirus ...
- Echovirus is one of several families of viruses that affect the gastrointestinal tract. Together, these are called "enteroviruses." These infections are common. In the United States, they are most common in the summer and ...
|リンク元||「エコーウイルス」「coxsackievirus B」「Coxsackie B virus」「human enterovirus B」|