early growth response protein 2

初期増殖応答タンパク質2

関

Egr-2

WordNet

1. very young; "at an early age"
2. before the usual time or the time expected; "she graduated early"; "the house was completed ahead of time" (同)ahead of time, too soon
3. in good time; "he awoke betimes that morning" (同)betimes
4. belonging to the distant past; "the early inhabitants of Europe"; "former generations"; "in other times" (同)former, other
5. at or near the beginning of a period of time or course of events or before the usual or expected time; "early morning"; "an early warning"; "early diagnosis"; "an early death"; "took early retirement"; "an early spring"; "early varieties of peas and tomatoes mature before most standard varieties"
6. being or occurring at an early stage of development; "in an early stage"; "early forms of life"; "early man"; "an early computer"
7. expected in the near future; "look for an early end to the negotiations"
8. of an early stage in the development of a language or literature; "the Early Hebrew alphabetical script is that used mainly from the 11th to the 6th centuries B.C."; "Early Modern English is represented in documents printed from 1476 to 1700"
9. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
10. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
11. become attached by or as if by the process of growth; "The tree trunks had grown together"
12. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
13. cause to grow or develop; "He grows vegetables in his backyard"
14. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
15. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
16. (pathology) an abnormal proliferation of tissue (as in a tumor)
17. a progression from simpler to more complex forms; "the growth of culture"
18. something grown or growing; "a growth of hair"
19. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
20. a result; "this situation developed in response to events in Africa"
21. a phrase recited or sung by the congregation following a versicle by the priest or minister
22. the manner in which an electrical or mechanical device responds to an input signal or a range of input signals
23. fruiting spike of a cereal plant especially corn (同)spike, capitulum
24. attention to what is said; "he tried to get her ear"
25. good hearing; "he had a keen ear"; "a good ear for pitch"
26. the sense organ for hearing and equilibrium

PrepTutorEJDIC

1. (時間・時期が)『早い』,『初期の』 / 昔の / (普通より,予定より)早い / 近い将来の / (時間・時期的に)『早く』 / (予定・ふだんより)早く
2. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
3. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
4. 〈C〉(…に対する)『返事』,『返答』《+『to』+『名』》 / 〈C〉〈U〉(…に対する)『反応』,『反響』《『to』+『名』》 / 〈C〉応答歌,応唱(牧師にならって合唱隊・会衆が短い祈り・歌を応答すること)
5. 〈C〉『耳』 / 《単数形で》『聴覚』,聴力,音感 / 《単数形で》じっと聞くこと,傾聴 / 〈C〉耳の形をした物
6. (麦・とうもろこしなどの)穂

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/18 11:56:13」(JST)

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Early growth response 2
PDB rendering based on 1a1i.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1a1i, 1a1j, 1a1k, 1a1l, 1aay, 1jk1, 1jk2, 1p47, 1zaa
Identifiers
Symbols	EGR2 ; AT591; CMT1D; CMT4E; KROX20
External IDs	OMIM: 129010 MGI: 95296 HomoloGene: 20123 GeneCards: EGR2 Gene
Gene ontology Molecular function • RNA polymerase II activating transcription factor binding • chromatin binding • sequence-specific DNA binding transcription factor activity • protein binding • ligase activity • ubiquitin protein ligase binding • transcription regulatory region DNA binding • metal ion binding • HMG box domain binding Cellular component • nucleus • cytoplasm Biological process • transcription from RNA polymerase II promoter • protein export from nucleus • brain development • peripheral nervous system development • learning or memory • rhythmic behavior • motor neuron axon guidance • cell death • Schwann cell differentiation • protein sumoylation • facial nerve structural organization • rhombomere 3 formation • rhombomere 5 formation • regulation of ossification • response to insulin • brain segmentation • skeletal muscle cell differentiation • myelination • negative regulation of apoptotic process • fat cell differentiation • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • regulation of neuronal synaptic plasticity • cellular response to cAMP • cellular response to gonadotropin stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1959	13654
Ensembl	ENSG00000122877	ENSMUSG00000037868
UniProt	P11161	P08152
RefSeq (mRNA)	NM_000399	NM_010118
RefSeq (protein)	NP_000390	NP_034248
Location (UCSC)	Chr 10: 64.57 – 64.68 Mb	Chr 10: 67.54 – 67.54 Mb
PubMed search	[1]	[2]

Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene.

Function

The early growth response protein 2 is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1D, Dejerine–Sottas disease, and Congenital Hypomyelinating Neuropathy

References

Further reading

• Rangnekar VM, Aplin AC, Sukhatme VP (May 1990). "The serum and TPA responsive promoter and intron-exon structure of EGR2, a human early growth response gene encoding a zinc finger protein". Nucleic Acids Research 18 (9): 2749–57. doi:10.1093/nar/18.9.2749. PMC 330760. PMID 2111009. 
• Chavrier P, Janssen-Timmen U, Mattéi MG, Zerial M, Bravo R, Charnay P (Feb 1989). "Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos". Molecular and Cellular Biology 9 (2): 787–97. PMC 362656. PMID 2496302. 
• Joseph LJ, Le Beau MM, Jamieson GA, Acharya S, Shows TB, Rowley JD et al. (Oct 1988). "Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure". Proceedings of the National Academy of Sciences of the United States of America 85 (19): 7164–8. doi:10.1073/pnas.85.19.7164. PMC 282144. PMID 3140236. 
• Topilko P, Schneider-Maunoury S, Levi G, Baron-Van Evercooren A, Chennoufi AB, Seitanidou T et al. (Oct 1994). "Krox-20 controls myelination in the peripheral nervous system". Nature 371 (6500): 796–9. doi:10.1038/371796a0. PMID 7935840. 
• Sham MH, Vesque C, Nonchev S, Marshall H, Frain M, Gupta RD et al. (Jan 1993). "The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation". Cell 72 (2): 183–96. doi:10.1016/0092-8674(93)90659-E. PMID 8093858. 
• Levi G, Topilko P, Schneider-Maunoury S, Lasagna M, Mantero S, Pesce B et al. (Jun 1996). "Role of Krox-20 in endochondral bone formation". Annals of the New York Academy of Sciences 785: 288–91. doi:10.1111/j.1749-6632.1996.tb56286.x. PMID 8702157. 
• Warner LE, Mancias P, Butler IJ, McDonald CM, Keppen L, Koob KG et al. (Apr 1998). "Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies". Nature Genetics 18 (4): 382–4. doi:10.1038/ng0498-382. PMID 9537424. 
• Warner LE, Svaren J, Milbrandt J, Lupski JR (Jul 1999). "Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies". Human Molecular Genetics 8 (7): 1245–51. doi:10.1093/hmg/8.7.1245. PMID 10369870. 
• Timmerman V, De Jonghe P, Ceuterick C, De Vriendt E, Löfgren A, Nelis E et al. (Jun 1999). "Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype". Neurology 52 (9): 1827–32. doi:10.1212/wnl.52.9.1827. PMID 10371530. 
• Bellone E, Di Maria E, Soriani S, Varese A, Doria LL, Ajmar F et al. (Oct 1999). "A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease". Human Mutation 14 (4): 353–4. doi:10.1002/(SICI)1098-1004(199910)14:4<353::AID-HUMU17>3.0.CO;2-4. PMID 10502832. 
• Pareyson D, Taroni F, Botti S, Morbin M, Baratta S, Lauria G et al. (Apr 2000). "Cranial nerve involvement in CMT disease type 1 due to early growth response 2 gene mutation". Neurology 54 (8): 1696–8. doi:10.1212/wnl.54.8.1696. PMID 10762521. 
• Gambardella L, Schneider-Maunoury S, Voiculescu O, Charnay P, Barrandon Y (Sep 2000). "Pattern of expression of the transcription factor Krox-20 in mouse hair follicle". Mechanisms of Development 96 (2): 215–8. doi:10.1016/S0925-4773(00)00398-1. PMID 10960786. 
• Yoshihara T, Kanda F, Yamamoto M, Ishihara H, Misu K, Hattori N et al. (Mar 2001). "A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot--Marie--Tooth disease type 1". Journal of the Neurological Sciences 184 (2): 149–53. doi:10.1016/S0022-510X(00)00504-9. PMID 11239949. 
• Boerkoel CF, Takashima H, Bacino CA, Daentl D, Lupski JR (Jul 2001). "EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy". Neurogenetics 3 (3): 153–7. doi:10.1007/s100480100107. PMID 11523566. 
• Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD (May 2002). "HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter". The Journal of Biological Chemistry 277 (22): 19482–7. doi:10.1074/jbc.M201687200. PMID 11909874. 
• Vandenberghe N, Upadhyaya M, Gatignol A, Boutrand L, Boucherat M, Chazot G et al. (Dec 2002). "Frequency of mutations in the early growth response 2 gene associated with peripheral demyelinating neuropathies". Journal of Medical Genetics 39 (12): e81. doi:10.1136/jmg.39.12.e81. PMC 1757229. PMID 12471219. 
• Musso M, Balestra P, Taroni F, Bellone E, Mandich P (Feb 2003). "Different consequences of EGR2 mutants on the transactivation of human Cx32 promoter". Neurobiology of Disease 12 (1): 89–95. doi:10.1016/S0969-9961(02)00018-9. PMID 12609493. 
• Unoki M, Nakamura Y (Apr 2003). "EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK". Oncogene 22 (14): 2172–85. doi:10.1038/sj.onc.1206222. PMID 12687019. 
• Numakura C, Shirahata E, Yamashita S, Kanai M, Kijima K, Matsuki T et al. (Jun 2003). "Screening of the early growth response 2 gene in Japanese patients with Charcot-Marie-Tooth disease type 1". Journal of the Neurological Sciences 210 (1-2): 61–4. doi:10.1016/S0022-510X(03)00028-5. PMID 12736090. 

External links

• GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 1
• GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 4
• EGR2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

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Related Links

• Early growth response protein 2 | definition of Early growth ...

Meaning of Early growth response protein 2 medical term. What does Early growth response protein 2 mean? Early growth response protein 2 | definition of Early growth response protein 2 by Medical dictionary http://medical ...

• EGR2 - early growth response 2 - Genetics Home Reference

The EGR2 gene provides instructions for making a protein called early growth response 2, which is part of the early growth response family of proteins. These proteins bind to specific areas of DNA and help control the activity of ...

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★リンクテーブル★

リンク元	「Egr-2」「初期増殖応答タンパク質2」
関連記事	「early」「grow」「response」「growth」「ear」

「Egr-2」

　　[★]

• 初期増殖応答タンパク質2

関

early growth response protein 2

「初期増殖応答タンパク質2」

　　[★]

英

early growth response protein 2、Egr-2

「early」

　　[★]

• adj.

• (比較級earlier-最上級earliest)早期の、初期の

• adv.

• 早く

関

archaic、beginning、early stage、early-stage、initial、initially、preterm、soon

　 　 　 　 　 　 　 　 　

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「response」

　　[★]

• n.

• 返答、応答
• 反応、感応、反響。(刺激に対する)反応

　 　 　 　

「growth」

　　[★]

• n.

• 成長

　 　 　 　 　 　

「ear」

　　[★]

• n.

• 耳