WordNet

very young; "at an early age"
before the usual time or the time expected; "she graduated early"; "the house was completed ahead of time" (同)ahead of time, too soon
in good time; "he awoke betimes that morning" (同)betimes
belonging to the distant past; "the early inhabitants of Europe"; "former generations"; "in other times" (同)former, other
at or near the beginning of a period of time or course of events or before the usual or expected time; "early morning"; "an early warning"; "early diagnosis"; "an early death"; "took early retirement"; "an early spring"; "early varieties of peas and tomatoes mature before most standard varieties"
being or occurring at an early stage of development; "in an early stage"; "early forms of life"; "early man"; "an early computer"
expected in the near future; "look for an early end to the negotiations"
of an early stage in the development of a language or literature; "the Early Hebrew alphabetical script is that used mainly from the 11th to the 6th centuries B.C."; "Early Modern English is represented in documents printed from 1476 to 1700"
fruiting spike of a cereal plant especially corn (同)spike, capitulum
attention to what is said; "he tried to get her ear"
good hearing; "he had a keen ear"; "a good ear for pitch"
the sense organ for hearing and equilibrium
a disorder of the central nervous system characterized by loss of consciousness and convulsions
a British peer ranking below a marquess and above a viscount

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1. 外傷後の痙攣とてんかん post traumatic seizures and epilepsy
2. 新生児てんかん症候群 neonatal epileptic syndromes
3. 若年性ミオクローヌスてんかん juvenile myoclonic epilepsy
4. 成人におけるてんかんのマネージメントの概要 overview of the management of epilepsy in adults
5. 小児痙攣およびてんかんの分類、病因、および臨床的特徴の概要 overview of the classification etiology and clinical features of pediatric seizures and epilepsy

Milanowski P1, Suffczynski P1.
International journal of neural systems.Int J Neural Syst.2016 Dec;26(8):1650053. Epub 2016 Aug 22.
Complex dynamical systems may exhibit sudden autonomous changes from one state to another. Such changes that occur rapidly in comparison to the regular dynamics have been termed critical transitions. Examples of such phenomena can be found in many complex systems: changes in climate and ocean circul
PMID 27633895

Prevalence of reported physical health problems in people with severe or profound intellectual and motor disabilities: a cross-sectional study of medical records and care plans.

van Timmeren EA1, van der Putten AA2, van Schrojenstein Lantman-de Valk HM3, van der Schans CP4,5, Waninge A4.
Journal of intellectual disability research : JIDR.J Intellect Disabil Res.2016 Nov;60(11):1109-1118. doi: 10.1111/jir.12298. Epub 2016 May 20.
BACKGROUND: People with severe or profound intellectual and motor disabilities (SPIMD) experience numerous serious physical health problems and comorbidities. Knowledge regarding the prevalence of these problems is needed in order to detect and treat them at an early stage. Data concerning these pro
PMID 27197564

Functional aspects of early brain development are preserved in tuberous sclerosis complex (TSC) epileptogenic lesions.

Ruffolo G1, Iyer A2, Cifelli P3, Roseti C4, Mühlebner A5, van Scheppingen J2, Scholl T6, Hainfellner JA7, Feucht M6, Krsek P8, Zamecnik J9, Jansen FE10, Spliet WG11, Limatola C12, Aronica E13, Palma E14.
Neurobiology of disease.Neurobiol Dis.2016 Nov;95:93-101. doi: 10.1016/j.nbd.2016.07.014. Epub 2016 Jul 16.
Tuberous sclerosis complex (TSC) is a rare multi-system genetic disease characterized by several neurological disorders, the most common of which is the refractory epilepsy caused by highly epileptogenic cortical lesions. Previous studies suggest an alteration of GABAergic and glutamatergic transmis
PMID 27425893

山本大介,内山剛,武内智康,佐藤慶史郎,清水貴子,田中惠子,大橋寿彦
臨床神経学 54(9), 715-720, 2014
症例は35歳男性である．発熱をともなう上気道炎の罹患1週間後に間代性痙攣で発症した．入院後複雑部分発作をくりかえし，複数の抗てんかん薬投与に抵抗性であった．ステロイドパルス療法，ガンマグロブリン静注療法にも反応なく第8病日から痙攣重積にいたった．経静脈麻酔による痙攣重積治療とともに血漿交換療法を施行し，発作は漸く抑制された．本症例の急性期の発症様式はNORSE（new-onset refracto …
NAID 130004696171

藤田直也,山本雅紀,深山雄大
Nihon Shoni Jinzobyo Gakkai Zasshi 26(2), 268-273, 2014
学校検尿で尿蛋白陽性を指摘されたことをきっかけに巣状分節性糸球体硬化症（FSGS）と診断された発達障害と下肢の痙性麻痺を伴う8 歳女児例を報告した。過去の記録では3 歳時の尿検査ですでに尿蛋白（2+）を指摘されており，それ以前の乳児期早期からすでに尿蛋白が出現していた可能性が推測された。原因の明らかにされていない発達障害，下肢の痙性麻痺を伴うことからAngelman症候群やその他の症候群，ミトコン …
NAID 130004495420