eIF5

• 真核生物翻訳開始因子5

関

eIF-5、eukaryotic initiation factor-5、eukaryotic translation initiation factor 5

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/30 01:27:27」(JST)

wiki en

[Wiki en表示]

Eukaryotic translation initiation factor 5
PDB rendering based on 2g2k.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2E9H, 2G2K, 2IU1
Identifiers
Symbols	EIF5 ; EIF-5; EIF-5A
External IDs	OMIM: 601710 MGI: 95309 HomoloGene: 49610 GeneCards: EIF5 Gene
Gene ontology Molecular function • translation initiation factor activity • GTPase activity • GTP binding • translation factor activity, nucleic acid binding • poly(A) RNA binding Cellular component • cytoplasm • cytosol • plasma membrane Biological process • GTP catabolic process • translation • translational initiation • regulation of translational initiation • gene expression • cellular protein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1983	217869
Ensembl	ENSG00000100664	ENSMUSG00000021282
UniProt	P55010	P59325
RefSeq (mRNA)	NM_001969	NM_173363
RefSeq (protein)	NP_001960	NP_775539
Location (UCSC)	Chr 14: 103.8 – 103.81 Mb	Chr 12: 111.54 – 111.55 Mb
PubMed search	[1]	[2]

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.

EIF5 is a GTPase-activating protein.

References

External links

• Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors

Further reading

• Das S, Maiti T, Das K, Maitra U (1998). "Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2.". J. Biol. Chem. 272 (50): 31712–8. doi:10.1074/jbc.272.50.31712. PMID 9395514. 
• Bandyopadhyay A, Maitra U (1999). "Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells.". Nucleic Acids Res. 27 (5): 1331–7. doi:10.1093/nar/27.5.1331. PMC 148320. PMID 9973622. 
• Das S, Maitra U (2000). "Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo.". Mol. Cell. Biol. 20 (11): 3942–50. doi:10.1128/MCB.20.11.3942-3950.2000. PMC 85746. PMID 10805737. 
• Choi SK, Olsen DS, Roll-Mecak A et al. (2000). "Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2.". Mol. Cell. Biol. 20 (19): 7183–91. doi:10.1128/MCB.20.19.7183-7191.2000. PMC 86272. PMID 10982835.  CS1 maint: Explicit use of et al. (link)
• Das S, Ghosh R, Maitra U (2001). "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein.". J. Biol. Chem. 276 (9): 6720–6. doi:10.1074/jbc.M008863200. PMID 11092890. 
• Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.  CS1 maint: Explicit use of et al. (link)
• Asano K, Shalev A, Phan L et al. (2001). "Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.". EMBO J. 20 (9): 2326–37. doi:10.1093/emboj/20.9.2326. PMC 125443. PMID 11331597.  CS1 maint: Explicit use of et al. (link)
• Majumdar R, Bandyopadhyay A, Deng H, Maitra U (2002). "Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo.". Nucleic Acids Res. 30 (5): 1154–62. doi:10.1093/nar/30.5.1154. PMC 101238. PMID 11861906. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  CS1 maint: Explicit use of et al. (link)
• Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners.". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535–40. doi:10.1073/pnas.0437845100. PMC 149867. PMID 12569173. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  CS1 maint: Explicit use of et al. (link)
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.  CS1 maint: Explicit use of et al. (link)
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  CS1 maint: Explicit use of et al. (link)
• Homma MK, Wada I, Suzuki T et al. (2005). "CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression.". Proc. Natl. Acad. Sci. U.S.A. 102 (43): 15688–93. doi:10.1073/pnas.0506791102. PMC 1266118. PMID 16227438.  CS1 maint: Explicit use of et al. (link)
• Conte MR, Kelly G, Babon J et al. (2006). "Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors.". Biochemistry 45 (14): 4550–8. doi:10.1021/bi052387u. PMID 16584190.  CS1 maint: Explicit use of et al. (link)
• Bieniossek C, Schütz P, Bumann M et al. (2006). "The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5.". J. Mol. Biol. 360 (2): 457–65. doi:10.1016/j.jmb.2006.05.021. PMID 16781736.  CS1 maint: Explicit use of et al. (link)
• Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  CS1 maint: Explicit use of et al. (link)

English Journal

• Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy.

• Martin-Marcos P, Nanda JS, Luna RE, Zhang F, Saini AK, Cherkasova VA, Wagner G, Lorsch JR, Hinnebusch AG.
• RNA (New York, N.Y.).RNA.2014 Feb;20(2):150-67. doi: 10.1261/rna.042069.113. Epub 2013 Dec 13.
• In the current model of translation initiation by the scanning mechanism, eIF1 promotes an open conformation of the 40S subunit competent for rapidly loading the eIF2·GTP·Met-tRNAi ternary complex (TC) in a metastable conformation (POUT) capable of sampling triplets entering the P site while block
• PMID 24335188

• The Scanning Mechanism of Eukaryotic Translation Initiation.

• Hinnebusch AG.
• Annual review of biochemistry.Annu Rev Biochem.2014 Jan 29. [Epub ahead of print]
• In eukaryotes, the translation initiation codon is generally identified by the scanning mechanism, wherein every triplet in the messenger RNA leader is inspected for complementarity to the anticodon of methionyl initiator transfer RNA (Met-tRNAi). Binding of Met-tRNAi to the small (40S) ribosomal su
• PMID 24499181

• The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.

• Luna RE1, Arthanari H, Hiraishi H, Akabayov B, Tang L, Cox C, Markus MA, Luna LE, Ikeda Y, Watanabe R, Bedoya E, Yu C, Alikhan S, Wagner G, Asano K.
• Biochemistry.Biochemistry.2013 Dec 31;52(52):9510-8. doi: 10.1021/bi4009775. Epub 2013 Dec 19.
• Scanning of the mRNA transcript by the preinitiation complex (PIC) requires a panel of eukaryotic initiation factors, which includes eIF1 and eIF1A, the main transducers of stringent AUG selection. eIF1A plays an important role in start codon recognition; however, its molecular contacts with eIF5 ar
• PMID 24319994

Japanese Journal

• The Role of Acetylation in the Subcellular Localization of an Oncogenic Isoform of Translation Factor eIF5A

• ISHFAQ Muhammad,MAETA Kazuhiro,MAEDA Satoko [他],NATSUME Toru,ITO Akihiro,YOSHIDA Minoru
• Bioscience, biotechnology, and biochemistry 76(11), 2165-2167, 2012-11-23
• NAID 10031126530

• The Role of Acetylation in the Subcellular Localization of an Oncogenic Isoform of Translation Factor eIF5A

• ISHFAQ Muhammad,MAETA Kazuhiro,MAEDA Satoko,NATSUME Toru,ITO Akihiro,YOSHIDA Minoru
• Bioscience, Biotechnology, and Biochemistry 76(11), 2165-2167, 2012
• … Mammalian cells express two isoforms of eIF5A, eIF5A1 and eIF5A2, but little is known about the function of eIF5A2. … Here we report that eIF5A2 is reversibly acetylated at lysine-47. … HDAC6 and SIRT2 were identified as the enzymes responsible for deacetylating eIF5A2. … Analysis using acetylation-deficient mutants indicated that acetylation regulates the subcellular localization of eIF5A2. …
• NAID 130004137870

• 3D1358 The Recognition Mechanism of eIF2β for its partner proteins eIF5 and eIF2β_ε(3D Protein: Structure & Function 3,The 49th Annual Meeting of the Biophysical Society of Japan)

• Gai Zuoqi,Kitagawa Yumie,Yao Min,Ose Toyoyuki,Tanaka Yoshikazu,Tanaka Isao
• 生物物理 51(SUPPLEMENT_1), S119-S120, 2011-08-15
• NAID 110008903445

Related Links

• 江戸前活ふぐ EIF5 [EIF5] - 7,720円

品番 標準全長(m) 継数(本) 仕舞(cm) 先径(m/m) 元径(m/m) 錘負荷(号) カーボン含有率(％) 自重(g) 税込価格 定価/実売 割引 数量 カートに入れる EIF5 1.5 2 111.5 0.7 15.7 10〜30 60 136 7,720円 オープン

• 抗EIF5ポリクローナル抗体 (Anti-EIF5) | ヒト組織免疫染色用抗体 ...

EIF5に対するポリクローナル抗体(Anti-EIF5)です。高品質なTriple A Polyclonalsブランド抗体となります。 ... お問い合わせ先（テクニカルサポート 試薬担当） mail フォームでのお問い合わせはこちら TEL/FAXでのお問い合わせはこちら

Related Pictures

---

★リンクテーブル★

リンク元	「真核生物翻訳開始因子5」「eukaryotic initiation factor-5」「eukaryotic translation initiation factor 5」
関連記事	「eIF」

「真核生物翻訳開始因子5」

　　[★]

英

eukaryotic initiation factor-5、eukaryotic translation initiation factor 5、eIF5、eIF-5

関

翻訳開始因子5

「eukaryotic initiation factor-5」

　　[★]

• 真核生物翻訳開始因子5、翻訳開始因子5

関

eIF-5、eIF5、eukaryotic translation initiation factor 5

「eukaryotic translation initiation factor 5」

　　[★]

• 真核生物翻訳開始因子5

関

eIF-5、eIF5、eukaryotic initiation factor-5

「eIF」

　　[★]

• 真核生物翻訳開始因子

関

eukaryotic initiation factor