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1. サラセミア症候群の分子病理 molecular pathology of the thalassemic syndromes
2. C型肝炎ウイルス感染に対する試験的治療 investigational therapies for hepatitis c virus infection
3. 成人における鉄欠乏性貧血の原因および診断 causes and diagnosis of iron deficiency anemia in the adult

English Journal

Identification and functional characterization of an endoplasmic reticulum oxidoreductin 1-α gene in Litopenaeus vannamei.

Zhang ZZ1, Yuan K1, Yue HT1, Yuan FH1, Bi HT1, Weng SP1, He JG2, Chen YH3.
Developmental and comparative immunology.Dev Comp Immunol.2016 Apr;57:10-9. doi: 10.1016/j.dci.2015.11.013. Epub 2015 Nov 26.
In the current study, full-length sequence of endoplasmic reticulum oxidoreductin 1-α (LvERO1-α) was cloned from Litopenaeus vannamei. Real-time RT-PCR results showed that LvERO1-α was highly expressed in hemocytes, gills, and intestines. White spot syndrome virus (WSSV) challenge was performed,
PMID 26631649

DBP-induced endoplasmic reticulum stress in male germ cells causes autophagy, which has a cytoprotective role against apoptosis in vitro and in vivo.

Zhang G1, Liu K2, Ling X3, Wang Z4, Zou P5, Wang X6, Gao J7, Yin L8, Zhang X9, Liu J10, Ao L11, Cao J12.
Toxicology letters.Toxicol Lett.2016 Mar 14;245:86-98. doi: 10.1016/j.toxlet.2016.01.016. Epub 2016 Jan 22.
Recently, spermatogenic cell apoptosis was shown to play a key role in the induction of testicular atrophy by dibutyl phthalate (DBP), thus causing reproductive toxicology. However, the molecular events induced by DBP in apoptotic germ cells remain unclear. In the present study, the mouse spermatocy
PMID 26804720

PFKFB3 modulates glycolytic metabolism and alleviates endoplasmic reticulum stress in human osteoarthritis cartilage.

Qu J1, Lu D2, Guo H1,3, Miao W1, Wu G1, Zhou M1.
Clinical and experimental pharmacology & physiology.Clin Exp Pharmacol Physiol.2016 Mar;43(3):312-8. doi: 10.1111/1440-1681.12537.
Glycolytic disorder has been demonstrated to be a major cause of osteoarthritis (OA) and chondrocyte dysfunction. The present work aimed to investigate the expression and role of the glycolytic regulator 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in OA cartilage. It was found th
PMID 26718307

Methylglyoxal activates Gcn2 to phosphorylate eIF2α independently of the TOR pathway in Saccharomyces cerevisiae.

Nomura Wataru,Maeta Kazuhiro,Kita Keiko,Izawa Shingo,Inoue Yoshiharu
Applied microbiology and biotechnology 86(6), 1887-1894, 2010-05
… Previously, we have reported that methylglyoxal attenuates the rate of overall protein synthesis in Saccharomyces cerevisiae through phosphorylation of the alpha subunit of translation initiation factor 2 (eIF2alpha) in a Gcn2-dependent manner. … Phosphorylation of eIF2alpha impedes the formation of a translation initiation complex, and subsequently, overall protein synthesis is reduced. …
NAID 120002383972

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha