WordNet
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
PrepTutorEJDIC
- answer / ampere
- arsenicの化学記号
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/12 19:01:41」(JST)
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- 1. 慢性疼痛の定義および病因 definition and pathogenesis of chronic pain
- 2. 成人における急性オピオイド中毒 acute opioid intoxication in adults
- 3. 性腺刺激ホルモン（ゴナドトロピン）放出ホルモンの生理学 physiology of gonadotropin releasing hormone
- 4. コルチコトロピン-放出ホルモン（CRH）の生理学 physiology of corticotropin releasing hormone
- 5. 尿毒症性そう痒症 uremic pruritus
English Journal
- Distinct physiological role of amidino-TAPA-sensitive and DAMGO-insensitive μ-opioid receptor splice variants in the mouse spinal cord.
- Mizoguchi H, Watanabe C, Higashiya T, Takeda S, Moriyama K, Aoki Y, Kon-No T, Takagi H, Yonezawa A, Sato T, Sakurada T, Sakurada S.SourceDepartment of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
- European journal of pharmacology.Eur J Pharmacol.2013 Apr 23. pii: S0014-2999(13)00307-5. doi: 10.1016/j.ejphar.2013.04.014. [Epub ahead of print]
- The physiological role of the distinct splice variants for cloned mouse μ-opioid receptor (mMOR-1), mMOR-1J, mMOR-1K and mMOR-1L, which are sensitive to Nα-amidino-Tyr-d-Arg-Phe-β-Ala (amidino-TAPA) and insensitive to [d-Ala2,N-MePhe4,Gly-ol5]enkephalin (DAMGO), was described in the mouse spinal
- PMID 23623932
- The One-Two Punch of Alcoholism: Role of Central Amygdala Dynorphins/Kappa-Opioid Receptors.
- Kissler JL, Sirohi S, Reis DJ, Jansen HT, Quock RM, Smith DG, Walker BM.SourceLaboratory of Alcoholism and Addictions Neuroscience, Department of Psychology (JLK, SS, DJR, BMW).
- Biological psychiatry.Biol Psychiatry.2013 Apr 20. pii: S0006-3223(13)00267-9. doi: 10.1016/j.biopsych.2013.03.014. [Epub ahead of print]
- BACKGROUND: The dynorphin (DYN)/kappa-opioid receptor (KOR) system undergoes neuroadaptations following chronic alcohol exposure that promote excessive operant self-administration and negative affective-like states; however, the exact mechanisms are unknown. The present studies tested the hypothesis
- PMID 23611261
- Nardilysin in human brain diseases: both friend and foe.
- Bernstein HG, Stricker R, Dobrowolny H, Steiner J, Bogerts B, Trübner K, Reiser G.SourceDepartment of Psychiatry, Otto-v.-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany, Hans-Gert.Bernstein@med.ovgu.de.
- Amino acids.Amino Acids.2013 Apr 19. [Epub ahead of print]
- Nardilysin is a metalloprotease that cleaves peptides, such as dynorphin-A, α-neoendorphin, and glucagon, at the N-terminus of arginine and lysine residues in dibasic moieties. It has various functionally important molecular interaction partners (heparin-binding epidermal growth factor-like growth
- PMID 23604405
Japanese Journal
- Dynorphin A (1-13) Alleviated Stress-Induced Behavioral Impairments in Mice
- Mamiya Takayoshi,Hasegawa Yuya,Hiramatsu Masayuki
- Biological & pharmaceutical bulletin 37(8), 1269-1273, 2014-08
- NAID 40020136554
- ストレス関連行動変化における内因性κ-オピオイドシステムの役割 : マウス学習性無力試験を用いた行動学的・神経化学的解析
- 間宮 隆吉
- 名城大学総合研究所総合学術研究論文集 (13), 11-17, 2014
- NAID 40020207536
- Dynorphin A (1–13) Alleviated Stress-Induced Behavioral Impairments in Mice
- Mamiya Takayoshi,Hasegawa Yuya,Hiramatsu Masayuki
- Biological and Pharmaceutical Bulletin 37(8), 1269-1273, 2014
- … In this study we investigated whether κ-opioid receptor stimulation by dynorphin A (1–13), a potent fragment of endogenous peptide, attenuated repeated stress-induced behavioral impairments in mice. … In order to reduce the motivation to escape, mice were preexposed to inescapable electric footshock (day 0), and then dynorphin A (1–13) was administered to mice prior to the stress from the next day for 4 d (days 1–4). …
- NAID 130004677531
Related Links
- Peptides , Dynorphin Peptides , Dynorphin A (1-17); YGGFLRRIRPKLKWDNQ; H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-OH ... Product Name Dynorphin A (1 - 17) YGGFLRRIRPKLKWDNQ Size 5 mg
- View and buy high purity Dynorphin A from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents ... References Dhawan et al (1996) International union of pharmacology XII. Classification of opioid ...
Related Pictures
![Dynorphin A [ 1 ]](https://1mg.info/0/c/i/1052.jpg)
★リンクテーブル★
| リンク元 | 「オピオイド」「ダイノルフィンA」 |
| 関連記事 | 「A」「Ad」 |
「オピオイド」
- 内因性のオピオイドペプチドが発見され、これらは内因性オピオイドペプチドと呼ばれるようになった。
作用
縮瞳
- モルフィンと多くのμ,κアゴニストは瞳孔の縮小を引き起こす。これは瞳孔を支配する副交感神経の興奮による。μアゴニストを中毒量投与すると縮瞳し、pinpoints pupupilsはpathognomonicである。(GOO.559)
オピオイドとオピオイド類似物質の作用
- GOO.552
| Drugs | RECEPTOR TYPES | ||
| μ受容体 | δ受容体 | κ受容体 | |
| morphine | ＋＋＋ | ＋ | |
| methadone | ＋＋＋ | ||
| etorphine | ＋＋＋ | ＋＋＋ | ＋＋＋ |
| levorphanol | ＋＋＋ | ||
| fentanyl | ＋＋＋ | ||
| sufentanil | ＋＋＋ | ＋ | ＋ |
| DAMGO | ＋＋＋ | ||
| butorphanol | P | ＋＋＋ | |
| buprenorphine | P | ーー | |
| naloxone | ーーー | ー | ーー |
| naltrexone | ーーー | ー | ーーー |
| CTOP | ーーー | ||
| diprenorphine | ーーー | ーー | ーーー |
| β-funaltrexamine | ーーー | ー | ＋＋ |
| naloxonazine | ーーー | ー | ー |
| nalorphine | ーーー | ＋ | |
| pentazocine | P | ＋＋ | |
| nalbuphine | ーー | ＋＋ | |
| naloxone benzoylhydrazone | ーーー | ー | ー |
| bremazocine | ＋＋＋ | ＋＋ | ＋＋＋ |
| ethylketocyclazocine | P | ＋ | ＋＋＋ |
| U50,488 | ＋＋＋ | ||
| U69,593 | ＋＋＋ | ||
| spiradoline | ＋ | ＋＋＋ | |
| nor-Binaltorphimine | ー | ー | ーーー |
| naltrindole | ー | ーーー | ー |
| DPDPE | ＋＋ | ||
| [[［[D-Ala2,Glu4］deltorphin]] | ＋＋ | ||
| DSLET | ＋ | ＋＋ | |
| endogenous Peptides | |||
| met-enkephalin | ＋＋ | ＋＋＋ | |
| leu-enkephalin | ＋＋ | ＋＋＋ | |
| β-endorphin | ＋＋＋ | ＋＋＋ | |
| dynorphin A | ＋＋ | ＋＋＋ | |
| dynorphin B | ＋ | ＋ | ＋＋＋ |
| α-neoendorphin | ＋ | ＋ | ＋＋＋ |
＋アゴニスト ーアンタゴニスト P partial agonist
各鎮痛薬のオピオイド受容体への作用
- μ受容体 κ受容体
- レミフェンタニル ＋＋＋ ー
- フェンタニル ＋＋＋ －
- モルヒネ ＋＋＋ ＋
- ペチジン ＋＋ ＋
- トラマドール ＋ －
- ペンタゾシン ー ＋＋
- ブプレノルフィン Ｐ ー
- ナロキソン ー －
「ダイノルフィンA」
- 英
- dynorphin A
- 関
- ダイノルフィン
「A」