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  • SNPs in candidate genes MX dynamin-like GTPase and chemokine (C-C motif) receptor-5 are associated with ovine pulmonary adenocarcinoma progression in Latxa sheep.
  • Larruskain A1, Esparza-Baquer A1, Minguijón E2, Juste RA2, Jugo BM1.
  • Animal genetics.Anim Genet.2015 Dec;46(6):666-75. doi: 10.1111/age.12351. Epub 2015 Sep 13.
  • Ovine pulmonary adenocarcinoma (OPA) is a contagious lung cancer in sheep caused by Jaagsiekte sheep retrovirus (JSRV). OPA is present in many sheep-rearing countries causing economic and welfare issues, as currently no efficient vaccines or treatments are available. Breed differences suggest a host
  • PMID 26365162
  • BDNF, via truncated TrkB receptor, modulates GlyT1 and GlyT2 in astrocytes.
  • Aroeira RI1, Sebastião AM1, Valente CA1.
  • Glia.Glia.2015 Dec;63(12):2181-97. doi: 10.1002/glia.22884. Epub 2015 Jul 21.
  • Glycine transporters (GlyT), GlyT1 and GlyT2, are responsible for the termination of glycine-mediated synaptic activity through removal of neurotransmitter from synaptic cleft. Brain-derived neurotrophic factor (BDNF) activates its high affinity tropomyosin-related kinase (Trk) receptors, namely Trk
  • PMID 26200505
  • Carboxylic Acid Fullerene (C60) Derivatives Attenuated Neuroinflammatory Responses by Modulating Mitochondrial Dynamics.
  • Ye S1, Zhou T, Cheng K, Chen M, Wang Y, Jiang Y, Yang P.
  • Nanoscale research letters.Nanoscale Res Lett.2015 Dec;10(1):953. doi: 10.1186/s11671-015-0953-9. Epub 2015 May 30.
  • Fullerene (C60) derivatives, a unique class of compounds with potent antioxidant properties, have been reported to exert a wide variety of biological activities including neuroprotective properties. Mitochondrial dynamics are an important constituent of cellular quality control and function, and an
  • PMID 26058514


  • Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced smad signaling in endothelial cells
  • Aki Sho,Yoshioka Kazuaki,Okamoto Yasuo,Takuwa Noriko,Takuwa Yoh
  • Journal of Biological Chemistry 290(10), 6086-6105, 2015-03-06
  • … Inhibition of dynamin, which is required for the clathrin-dependent receptor endocytosis, suppressed both TGFβ receptor internalization and Smad2/3 phosphorylation. … TGFβ1 stimulated Smad-dependent VEGF-A expression, VEGF receptor-mediated EC migration, and capillary-like tube formation, which were all abolished by either PI3K-C2α knockdown or a dynamin inhibitor. …
  • NAID 120005593954
  • Mdivi-1, mitochondrial fission inhibitor, impairs developmental competence and mitochondrial function of embryos and cells in pigs
  • , , [他], , , , , , , , ,
  • Journal of Reproduction and Development 61(2), 81-89, 2015
  • … Mitochondria are highly dynamic organelles that undergo constant fusion/fission as well as activities orchestrated by large dynamin-related GTPases. …
  • NAID 130005064914
  • The Dynamin 2 inhibitor Dynasore affects the actin filament distribution during mouse early embryo development
  • , , [他], , , ,
  • Journal of Reproduction and Development 61(1), 49-53, 2015
  • Dynamin 2 is a large GTPase notably involved in clathrin-mediated endocytosis, cell migration and cytokinesis in mitosis. … Our previous study identified that Dynamin 2 regulated polar body extrusion in mammalian oocytes, but its roles in early embryo development, remain elusive. … Here, we report the critical roles of Dynamin 2 in mouse early embryo development. … Dynamin 2 accumulated at the periphery of the blastomere during embryonic development. …
  • NAID 130004774179


Function [edit] As a vesicle invaginates, dynamin forms a spiral around the neck of the vesicle. Once the spiral is in place, it extends lengthwise and constricts through GTP hydrolysis. This lengthening and tightening of the coil around ...
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