WordNet

a complex consisting of an organic base in association with hydrogen chloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/03 17:21:56」(JST)

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Dyclonine is an oral anaesthetic that is the active ingredient of Sucrets, an over the counter throat lozenge.^[1] It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt.^[2]

History

The product Sucrets was introduced in Baltimore, Maryland, by Sharp & Dohme in 1932.^[3]

In 1966 the Federal Trade Commission ordered Merck and Company to discontinue the false claims of germ-killing and pain-relieving properties for its Sucrets and Children's Sucrets throat lozenges.^[4] In 1977, it was acquired by Beecham, later merging with SmithKline Beckman in 1989 to form SmithKline Beecham. By 1994 the brand switched from a metal container to a plastic container.^[3] SmithKline Beecham, after announcing a merger with GlaxoWellcome to form GlaxoSmithKline, sold the brand in 2000 to Insight Pharmaceuticals. In 2011, Sucrets reintroduced their product back into the familiar tin due to popular demand and nostalgia.

References

^ Janice Jorgensen (1994). "Sucrets". Encyclopedia of Consumer Brands: Personal products. St. James Press. Retrieved 2011-09-24.
^ Gargiulo, A. V.; Burns, G. M.; Huck, C. P. (1992). "Dyclonine hydrochloride--a topical agent for managing pain". Illinois dental journal 61 (4): 303–304. PMID 1286862.
^ ^a ^b "The Sucrets tin joins the age of plastics". USA Today. July 19, 1994. Retrieved 2011-09-24. Invented in Baltimore by Sharp & Dohme pharmaceutical in 1932, Sucrets have always been sold in the trademark metal box except for one 4 1/2-month period during the late 1960s when a tin shortage led to cardboard packaging, says [Frank Dzvonik].
^ "F.T.C. Bids Merck Halt Claims That Lozenges Will Kill Germs". Associated Press in the New York Times. April 19, 1966. Retrieved 2011-09-24.

External links

Sucrets: Our heritage

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UpToDate Contents

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1. 粘膜類天疱瘡のマネージメント management of mucous membrane pemphigoid
2. 成人における急性咽頭炎の対症療法 symptomatic treatment of acute pharyngitis in adults

English Journal

Development of a HPLC/MS/MS method for simultaneous determination of tinidazole, dyclonine and chlorhexidine in rat plasma and its application in the pharmacokinetic research of a film-forming solution.

Wu L, Liu J, Zhang Y, Hou Y.SourceHebei Medical University, 361 East Zhongshan Road, Shijiazhuang 050017, China.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2012 Mar 25;62:224-7. doi: 10.1016/j.jpba.2012.01.009. Epub 2012 Jan 16.
A rapid and sensitive HPLC/MS/MS method was developed and validated for simultaneous determination of tinidazole, dyclonine and chlorhexidine, the three main components of a film-forming solution, in rat plasma. The plasma samples were pretreated by solid phase extraction (SPE) method. Separation wa
PMID 22305084

In Silico Studies on Fungal Metabolite against Skin Cancer Protein (4,5-Diarylisoxazole HSP90 Chaperone).

Kandasamy S, Sahu SK, Kandasamy K.SourceCentre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608 502, India.
ISRN dermatology.ISRN Dermatol.2012;2012:626214. Epub 2012 Sep 6.
This work was to find out the dominant secondary metabolites derived from the fungus Trichoderma and to test them against skin cancer protein. The metabolites were extracted in 80% methanol from the fungal biomass of Trichoderma isolated from mangrove sediment. The crude methanol extract was purifie
PMID 22991673

Microneedle pretreatment improves efficacy of cutaneous topical anesthesia.

Li X, Zhao R, Qin Z, Zhang J, Zhai S, Qiu Y, Gao Y, Xu B, Thomas SH.SourceDepartments of Pharmacy and Plastic Surgery, Peking University Third Hospital, Beijing 100083, China.
The American journal of emergency medicine.Am J Emerg Med.2010 Feb;28(2):130-4. doi: 10.1016/j.ajem.2008.10.001.
Methods to facilitate topical anesthesia for venipuncture are characterized by substantial limitations. This randomized double-blind study was undertaken to assess whether use of a quickly and painlessly applied microneedle system (functional microarray, FMA) to create punctures in the stratum corne
PMID 20159380

Japanese Journal

1%Dyclonine Hydrochlorideレスタミン軟膏の止痒効果

出川智久 [他]
臨床皮膚泌尿器科 12(7), ????, 1958-07
NAID 40018623749

Related Pictures

★リンクテーブル★

リンク元	「ジクロニン」「塩酸ジクロニン」「DYCLONE」「SKIN SHIELD」「SUCRETS」
関連記事	「dyclonine」「hydrochloride」

「ジクロニン」

Dyclonine
Systematic (IUPAC) name
	1-(4-butoxyphenyl)-3-(1-piperidyl)propan-1-one
Clinical data
Trade names	Sucrets
AHFS/Drugs.com	monograph
Pregnancy; category	US: C (Risk not ruled out);
Legal status	US: OTC;
Routes of; administration	Lozenge
Identifiers
CAS Registry Number	586-60-7
ATC code	N01BX02 R02AD04
PubChem	CID: 3180
IUPHAR/BPS	7173
DrugBank	DB00645
ChemSpider	3068
UNII	078A24Q30O
KEGG	D07881
ChEBI	CHEBI:4724
ChEMBL	CHEMBL1201217
Chemical data
Formula	C18H27NO2
Molecular mass	289.413 g/mol
	SMILES O=C(c1ccc(OCCCC)cc1)CCN2CCCCC2 ;
	InChI InChI=1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3 ; Key:BZEWSEKUUPWQDQ-UHFFFAOYSA-N ;
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