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English Journal
- Studies of phase transitions in the aripiprazole solid dosage form.
- Łaszcz M1, Witkowska A2.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2016 Jan 5;117:298-303. doi: 10.1016/j.jpba.2015.09.004. Epub 2015 Sep 5.
- Studies of the phase transitions in an active substance contained in a solid dosage form are very complicated but essential, especially if an active substance is classified as a BCS Class IV drug. The purpose of this work was the development of sensitive methods for the detection of the phase transi
- PMID 26397209
- Study on the pharmacokinetic profiles of corynoline and its potential interaction in traditional Chinese medicine formula Shuanghua Baihe tablets in rats by LC-MS/MS.
- Liu R1, Gu P1, Wang L1, Cheng M1, Wu Y1, Zheng L2, Liu Y2, Ding L3.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2016 Jan 5;117:247-54. doi: 10.1016/j.jpba.2015.09.009. Epub 2015 Sep 10.
- Corynoline, the major isoquinoline alkaloid component derived from Corydalis bungeana Herba, has greatly impressed many scientists due to its various pharmacological effects. However, there is little information on its pharmacokinetics. In this study, a sensitive and rapid liquid chromatography with
- PMID 26386954
Japanese Journal
- Efficacy of 2-Hydroxypropyl-β-cyclodextrin in Niemann–Pick Disease Type C Model Mice and Its Pharmacokinetic Analysis in a Patient with the Disease
- , , , , , , , , , , , , , , , ,
- Biological and Pharmaceutical Bulletin 38(6), 844-851, 2015
- … A solubilizing agent of lipophilic compounds, 2-hydroxypropyl-β-cyclodextrin (HPBCD), is an attractive drug candidate against NPC disease. … However, establishment of the optimum dosage of HPBCD remains to be determined. … In this study, we evaluated the effective dosage of HPBCD in NPC model (Npc1−/−) mice, and determined serum HPBCD concentrations. …
- NAID 130005072664
- Development and Characterization of Solid Self-emulsifying Drug Delivery System of Cilnidipine
- ,
- Chemical and Pharmaceutical Bulletin 63(6), 408-417, 2015
- … The present investigations highlight the development of solid self-emulsifying drug delivery system (solid-SEDDS) for improved oral delivery of the poorly water-soluble drug; … Liquid SEDDS of the drug were formulated using Capryol 90 as the oil phase, Tween 80 as the surfactant, and Transcutol HP as the co-surfactant after screening various vehicles. …
- NAID 130005072106
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