- specific enzymes
- Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers.
- Metzger IF1, Quigg TC2, Epstein N1, Aregbe AO1, Thong N1, Callaghan JT3, Flockhart DA1, Nguyen AT1, Stevens CK1, Gupta SK4, Desta Z1.
- Current therapeutic research, clinical and experimental.Curr Ther Res Clin Exp.2014 Sep 27;76:64-9. doi: 10.1016/j.curtheres.2014.05.002. eCollection 2014.
- BACKGROUND: Efavirenz exhibits multiple interactions with drug-metabolizing enzymes and transporters, and for this reason efavirenz-based HIV therapy is associated with altered pharmacokinetics of coadministered drugs. Probably by the same mechanism, efavirenz-based HIV therapy affects the dispositi
- PMID 25352936
- Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans.
- Darwich AS1, Aslam U2, Ashcroft DM2, Rostami-Hodjegan A2.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2014 Dec;42(12):2016-22. doi: 10.1124/dmd.114.058404. Epub 2014 Sep 18.
- Due to the rapid turnover of the small intestinal epithelia, the rate at which enterocyte renewal occurs plays an important role in determining the level of drug-metabolizing enzymes in the gut wall. Current physiologically based pharmacokinetic (PBPK) models consider enzyme and enterocyte recovery
- PMID 25233858
- DNA methylation and personalized medicine.
- Tang J1, Xiong Y, Zhou HH, Chen XP.
- Journal of clinical pharmacy and therapeutics.J Clin Pharm Ther.2014 Dec;39(6):621-7. doi: 10.1111/jcpt.12206. Epub 2014 Sep 17.
- WHAT IS KNOWN AND OBJECTIVE: Variation in the expression of drug-response-related genes contributes significantly to interindividual differences in drug response. DNA methylation is one of the most common epigenetic modifications that control gene expression. DNA methylation may occur in genes encod
- PMID 25230364
- 1. Curr Drug Metab. 2000 Sep;1(2):107-32. Drug-metabolizing enzymes: mechanisms and functions. Sheweita SA(1). Author information: (1)Department of Bioscience and Technology, Institute of Graduate Studies and ...
- Fetal exposure to xenobiotics is modulated to a considerable degree by the metabolic capabilities of the mother and the placenta. However, once liberated from t ... where CL metabolic refers to metabolism by organs capable of drug ...
- do drugs