出典: meddic


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「a tricyclic antidepressant (trade names Adapin and Sinequan) with numerous side effects (dry mouth and sedation and gastrointestinal disturbances)」
doxepin hydrochloride, Adapin, Sinequan

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/01/29 12:34:48」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/09 11:06:05」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/09/17 23:38:28」(JST)

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  • An evidence-based review of systemic treatments for itch.
  • Pongcharoen P1, Fleischer AB Jr2.
  • European journal of pain (London, England).Eur J Pain.2016 Jan;20(1):24-31. doi: 10.1002/ejp.766. Epub 2015 Sep 28.
  • BACKGROUND AND OBJECTIVE: Many treatment modalities are used for itch treatment in daily medical practices without adequate evidence of their efficacy. The purpose of this study was to provide an evidence-based review of the literature as to the clinical benefits of systemic anti-itch treatments.DAT
  • PMID 26416344
  • The effect of histamine on changes in mental energy and fatigue after a single bout of exercise.
  • Loy BD1, O'Connor PJ2.
  • Physiology & behavior.Physiol Behav.2016 Jan 1;153:7-18. doi: 10.1016/j.physbeh.2015.10.016. Epub 2015 Oct 19.
  • The purpose of this research was to determine if histamine, acting on brain H1 receptors, influences changes in feelings of energy and fatigue or cognitive test performance after acute exercise. Women (n=20) with low vigor and high fatigue were administered the H1 antagonist drug doxepin hydrocholor
  • PMID 26482543
  • Human UDP-glucuronosyltransferase (UGT) 2B10: Validation of cotinine as a selective probe substrate, inhibition by UGT enzyme selective inhibitors and antidepressant and antipsychotic drugs, and structural determinants of enzyme inhibition.
  • Pattanawongsa A1, Nair PC1, Rowland A1, Miners JO2.
  • Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2015 Dec 15. pii: dmd.115.068213. [Epub ahead of print]
  • Although there is evidence for an important role of UGT2B10 in the N-glucuronidation of drugs and other xenobiotics, the inhibitor selectivity of this enzyme is poorly understood. This study sought primarily to characterize the inhibition selectivity of UGT2B10 by UDP-glucuronosyltransferase (UGT) e
  • PMID 26669329


  • G タンパク質共役型受容体の構造解析に向けた戦略 ~ヒスタミンH1受容体を例に~
  • 白石 充典
  • YAKUGAKU ZASSHI 133(5), 539-547, 2013
  • … We also present our success in determining the crystal structure of the histamine H1 receptor (H1R) in complex with doxepin, an inverse agonist antihistamine. … The H1R structure revealed the low selectivity of doxepin to aminergic receptors and provides key information that should aid the development of highly selective antihistamines. …
  • NAID 130003361947
  • Structure of the human histamine H1 receptor complex with doxepin.
  • Shimamura Tatsuro,Shiroishi Mitsunori,Weyand Simone,Tsujimoto Hirokazu,Winter Graeme,Katritch Vsevolod,Abagyan Ruben,Cherezov Vadim,Liu Wei,Han Gye Won,Kobayashi Takuya,Stevens Raymond C,Iwata So
  • Nature 475(7354), 65-70, 2011-07-07
  • … Here we show the crystal structure of the H(1)R complex with doxepin, a first-generation H(1)R antagonist. … Doxepin sits deep in the ligand-binding pocket and directly interacts with Trp 428(6.48), a highly conserved key residue in G-protein-coupled-receptor activation. …
  • NAID 120004225543
  • Hangover Effect of Orally Administered Antihistamines Measured by Brain Histamine H1 Receptor Occupancy Using PET and 11C-doxepin: A Comparison between Diphenhydramine and Bepotastine in Healthy Subjects
  • Zhang D.,Tashiro M.,Okamura N.,Shibuya K.,Funaki Y.,Watanuki S.,Yanai K.
  • CYRIC annual report 2009, 174-178, 2009
  • NAID 120003142953







Adapin, Sinequan

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