downregulation

出典: meddic

  • n.
declinedecreasediminishdiminutiondown-regulatedown-regulationdownmodulationdownregulatefalllossreceptor down-regulationreducereduction

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/02/18 22:36:47」(JST)

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英文文献

  • Exposure of Female Rats to an Environmentally Relevant Mixture of Brominated Flame Retardants Targets the Ovary, Affecting Folliculogenesis and Steroidogenesis.
  • Lefèvre PL1, Berger RG1, Ernest SR1, Gaertner DW2, Rawn DF2, Wade MG3, Robaire B4, Hales BF5.
  • Biology of reproduction.Biol Reprod.2016 Dec;94(1):9. doi: 10.1095/biolreprod.115.134452. Epub 2015 Nov 25.
  • Brominated flame retardants (BFRs) are incorporated into various consumer products to prevent flame propagation. These compounds leach into the domestic environment, resulting in chronic exposure and contamination. Pregnancy failure is associated with high levels of BFRs in human follicular fluid, r
  • PMID 26607716
  • Integrative analysis of copy number and gene expression data suggests novel pathogenetic mechanisms in primary myelofibrosis.
  • Salati S1, Zini R1, Nuzzo S2, Guglielmelli P3, Pennucci V1, Prudente Z1, Ruberti S1, Rontauroli S1, Norfo R1, Bianchi E1, Bogani C3, Rotunno G3, Fanelli T3, Mannarelli C3, Rosti V4, Salmoiraghi S5, Pietra D6, Ferrari S2, Barosi G4, Rambaldi A5, Cazzola M6, Bicciato S2, Tagliafico E2, Vannucchi AM3, Manfredini R1; AGIMM (AIRC Gruppo Italiano Malattie Mieloproliferative) investigators.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2016 Apr 1;138(7):1657-69. doi: 10.1002/ijc.29920. Epub 2015 Nov 25.
  • Primary myelofibrosis (PMF) is a Myeloproliferative Neoplasm (MPN) characterized by megakaryocyte hyperplasia, progressive bone marrow fibrosis, extramedullary hematopoiesis and transformation to Acute Myeloid Leukemia (AML). A number of phenotypic driver (JAK2, CALR, MPL) and additional subclonal m
  • PMID 26547506
  • Modified pectic polysaccharide from turmeric (Curcuma longa): A potent dietary component against gastric ulcer.
  • Harsha MR1, Chandra Prakash SV1, Dharmesh SM2.
  • Carbohydrate polymers.Carbohydr Polym.2016 Mar 15;138:143-55. doi: 10.1016/j.carbpol.2015.11.043. Epub 2015 Dec 2.
  • Native, intact (TrPP) and modified, low-molecular-weight (MTrPP) forms of pectic polysaccharides isolated from turmeric were evaluated for ulcer-preventive potentials in in vitro and in vivo models. Data indicated that MTrPP possessed significantly better ulcer-preventive property than TrPP; inhibit
  • PMID 26794747

和文文献

  • Heme oxygenase-1 alleviates alcoholic liver steatosis: histopathological study
  • Knockdown of AT-rich interaction domain (ARID) 5B gene expression induced AMPKα2 activation in cardiac myocytes
  • INTRA-GOLGI CONNEXIN26 BEHAVES IN A PRO-ONCOGENIC MANNER IN HEAD AND NECK CANCER CELLS

関連リンク

downregulation 【名】下方制御 - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。 ... HOME 通信講座 出版物 メールマガジン セミナー 会員 ...
しかし、それを越えて継続使用すると左のグラフのように、急激なゴナドトロピン分泌の低下が起こり、卵巣が刺激されなくなるので女性ホルモンも閉経レベルに低下します。(ダウンレギュレーション。)

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★リンクテーブル★
先読みfall」「ダウンレギュレーション
リンク元reduce」「decrease」「loss」「decline」「reduction

fall」

  [★]

  • vi.
  • n.
  • [Fall](米)秋(autumn)。[形容詞的に]秋の、秋向きの
  • (単数形)(~からの)落下、墜落。落下距離、落差(from)
  • (単数形)(多くの落下部分からなる幅の広い)滝
  • (単数形)降雨(量)、降雪(量)
  • 転倒。倒壊。戦死
  • (単数形)(~の)下落、降下、減少(in)
  • (アクセントなどの)あるべき位置
  • (the ~; 単数形)(都市などの)陥落。没落、滅亡、崩壊、政権を失うこと
  • (Fall]/[the/a ~]堕落。(神学)罪
  • 傾斜、勾配
  • 垂れ下がる物。(女性の)垂れ下がった付け毛。(テリヤ犬などの)顔面に垂れている房毛

WordNet   license wordnet

「yield to temptation or sin; "Adam and Eve fell"」

WordNet   license wordnet

「the season when the leaves fall from the trees; "in the fall of 1973"」
autumn

WordNet   license wordnet

「come as if by falling; "Night fell"; "Silence fell"」
descend, settle

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「be born, used chiefly of lambs; "The lambs fell in the afternoon"」

WordNet   license wordnet

「begin vigorously; "The prisoners fell to work right away"」

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「go as if by falling; "Grief fell from our hearts"」

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「occur at a specified time or place; "Christmas falls on a Monday this year"; "The accent falls on the first syllable"」

WordNet   license wordnet

「pass suddenly and passively into a state of body or mind; "fall into a trap"; "She fell ill"; "They fell out of favor"; "Fall in love"; "fall asleep"; "fall prey to an imposter"; "fall into a strange way of thinking"; "she fell to pieces after she lost her work"」

WordNet   license wordnet

「a lapse into sin; a loss of innocence or of chastity; "a fall from virtue"」

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「a sudden decline in strength or number or importance; "the fall of the House of Hapsburg"」
downfall

WordNet   license wordnet

「when a wrestler''s shoulders are forced to the mat」
pin

WordNet   license wordnet

「a movement downward; "the rise and fall of the tides"」

PrepTutorEJDIC   license prepejdic

「《しばしば副詞[句]を伴って》『落下する』,落ちる / 〈人・物が〉『倒れる』《+『down』(『over』)》 / 傷ついて倒れる,倒れて死ぬ / (…まで)垂れ下がる,〈道などが〉下降する《+『to』+『名』》 / 〈目・顔などが〉下を向く,うつむく,沈む / 〈暗やみ・静けさなどが〉(…に)たれ込める;〈災害・責任・病気・眠けなどが〉(…に)降りかかる《+『on』(『upon, over』)+『名』》 / 〈程度・数量・値段などが〉(…まで)『下がる』,減少する《+『to』+『名』》 / 誘惑に負ける,墜落する / (勢力・威信・人望などを)失う《+『from』(『in』)+『名』》 / 〈政権などが〉倒れる,〈要塞などが〉陥落する;(…の手に)落ちる《+『to』+『名』》 / 『なる』,陥る / 〈時・事が〉(…に)当たる,起こる,(しかるべき位置に)来る《+『on』(『upon』)+『名』》 / 〈光線・視線などが〉(…に)向けられる《+『on』(『upon』)+『名』 / (…に)分かれる《+『into』+『名』》 / 〈言葉などが〉(…から)漏れる《+『from』》 / 〈C〉(…から)『落ちること』,落下《+『from』+『名』》;(…への)落下《+『to』(『toward』)+『名』》 / 〈C〉(雨・雪などの)降った量《+『of』+『名』》 / 《複数形で》《固有名詞としては単数扱い》滝 / 〈C〉(…から…までの)落差《+『from』+『名』+『to』+『名』》 / 〈C〉倒れること,転倒 / 〈C〉(程度・数量・値段などの)下落,減少,衰退《+『in』+『名』》 / 《単数形で》(…の)陥落,崩壊《+『of』+『名』》 / 〈U〉堕落 / 〈C〉傾斜」

PrepTutorEJDIC   license prepejdic

「『秋』(autumn)」

WordNet   license wordnet

「come under, be classified or included; "fall into a category"; "This comes under a new heading"」
come

WordNet   license wordnet

「lose an upright position suddenly; "The vase fell over and the water spilled onto the table"; "Her hair fell across her forehead"」
fall down

WordNet   license wordnet

「fall to somebody by assignment or lot; "The task fell to me"; "It fell to me to notify the parents of the victims"」
light

WordNet   license wordnet

「be inherited by; "The estate fell to my sister"; "The land returned to the family"; "The estate devolved to an heir that everybody had assumed to be dead"」
return, pass, devolve

WordNet   license wordnet

「touch or seem as if touching visually or audibly; "Light fell on her face"; "The sun shone on the fields"; "The light struck the golden necklace"; "A strange sound struck my ears"」
shine, strike

WordNet   license wordnet

「assume a disappointed or sad expression; "Her face fell when she heard that she would be laid off"; "his crest fell"」

WordNet   license wordnet

「be captured; "The cities fell to the enemy"」

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「be cast down; "his eyes fell"」

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「be due; "payments fall on the 1st of the month"」

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「come out; issue; "silly phrases fell from her mouth"」

WordNet   license wordnet

「descend in free fall under the influence of gravity; "The branch fell from the tree"; "The unfortunate hiker fell into a crevasse"」

WordNet   license wordnet

「die, as in battle or in a hunt; "Many soldiers fell at Verdun"; "Several deer have fallen to the same gun"; "The shooting victim fell dead"」

WordNet   license wordnet

「drop oneself to a lower or less erect position; "She fell back in her chair"; "He fell to his knees"」

WordNet   license wordnet

「lose office or power; "The government fell overnight"; "The Qing Dynasty fell with Sun Yat-sen"」

WordNet   license wordnet

「lose one''s chastity; "a fallen woman"」

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「move in a specified direction; "The line of men fall forward"」

WordNet   license wordnet

「slope downward; "The hills around here fall towards the ocean"」

WordNet   license wordnet

「suffer defeat, failure, or ruin; "We must stand or fall"; "fall by the wayside"」

WordNet   license wordnet

「to be given by assignment or distribution; "The most difficult task fell on the youngest member of the team"; "The onus fell on us"; "The pressure to succeed fell on the youngest student"」

WordNet   license wordnet

「to be given by right or inheritance; "The estate fell to the oldest daughter"」


ダウンレギュレーション」

  [★]

down-regulation, down regulation
下向き調節



reduce」

  [★]

  • vt.
  • 減少させる、縮小させる、減らす、(化学)還元する
  • vi.
  • (細胞などが)縮小する
declinedecreasediminishdiminutiondown-regulatedown-regulationdownregulatedownregulationfalllessenlossreductiontaper

WordNet   license wordnet

「undergo meiosis; "The cells reduce"」

WordNet   license wordnet

「cook until very little liquid is left; "The cook reduced the sauce by boiling it for a long time"」
boil down, concentrate

WordNet   license wordnet

「be the essential element; "The proposal boils down to a compromise"」
come down, boil down

WordNet   license wordnet

「take off weight」
melt off, lose weight, slim, slenderize, thin, slim down

WordNet   license wordnet

「make smaller; "reduce an image"」
scale down

WordNet   license wordnet

「narrow or limit; "reduce the influx of foreigners"」
tighten

WordNet   license wordnet

「make less complex; "reduce a problem to a single question"」

WordNet   license wordnet

「cut down on; make a reduction in; "reduce your daily fat intake"; "The employer wants to cut back health benefits"」
cut down, cut back, trim, trim down, trim back, cut, bring down

WordNet   license wordnet

「bring to humbler or weaker state or condition; "He reduced the population to slavery"」

WordNet   license wordnet

「destress and thus weaken a sound when pronouncing it」

WordNet   license wordnet

「lessen and make more modest; "reduce one''s standard of living"」

WordNet   license wordnet

「lower in grade or rank or force somebody into an undignified situation; "She reduced her niece to a servant"」

WordNet   license wordnet

「reposition (a broken bone after surgery) back to its normal site」

WordNet   license wordnet

「simplify the form of a mathematical equation of expression by substituting one term for another」

PrepTutorEJDIC   license prepejdic

「(あるところまで)〈数量など〉‘を'『減らす』,小さくする;〈程度・地位など〉‘を'『下げる』《+『名』+『to』+『名』》 / 《しばしば受動態で》(ある状態・形に)…‘を'『する,』変える,至らせる《+『名』+『to』+『名』(do『ing』)》 / (単純な要素・部分に)…‘を'分解する,還元する《+『名』+『to』+『名』》 / …‘を'(…に)換算する,約分する《+『名』+『to』+『名』》 / 《話》〈人が〉減量する / 〈数量などが〉減る;〈程度・位などが〉下がる」


decrease」

  [★]

  • vt.vi.
  • 減少する/させる。縮小する/させる。(力・温度など)低下する/させる、衰える/衰えさせる
  • n.
  • 減少、縮小、低下。減少/縮小/低下の数/量/額/率/度合い
declinedepressiondiminishdiminutiondown-regulatedown-regulationdownregulatedownregulationdropfalllessenlosslowerloweringreducereductiontaper

WordNet   license wordnet

「make smaller; "He decreased his staff"」
lessen, minify

WordNet   license wordnet

「a process of becoming smaller or shorter」
decrement

WordNet   license wordnet

「decrease in size, extent, or range; "The amount of homework decreased towards the end of the semester"; "The cabin pressure fell dramatically"; "her weight fell to under a hundred pounds"; "his voice fell to a whisper"」
diminish, lessen, fall

WordNet   license wordnet

「the amount by which something decreases」
decrement

WordNet   license wordnet

「the act of decreasing or reducing something」
diminution, reduction, step-down

WordNet   license wordnet

「a change downward; "there was a decrease in his temperature as the fever subsided"; "there was a sharp drop-off in sales"」
lessening, drop-off

PrepTutorEJDIC   license prepejdic

「…'を'『減らす』 / 『減る』,少なくなる / 〈U〉〈C〉(…の)『減少』,縮小《+『in』+『名』》 / 〈C〉(…の)減少量(額)《+『in』(『of』)+『名』》」


loss」

  [★]

  • n.
declinedecreasediminishdiminutiondown-regulatedown-regulationdownregulatedownregulationfallreducereduction


WordNet   license wordnet

「the amount by which the cost of a business exceeds its revenue; "the company operated at a loss last year"; "the company operated in the red last year"」
red ink, red

WordNet   license wordnet

「gradual decline in amount or activity; "weight loss"; "a serious loss of business"」

WordNet   license wordnet

「something that is lost; "the car was a total loss"; "loss of livestock left the rancher bankrupt"」

WordNet   license wordnet

「the disadvantage that results from losing something; "his loss of credibility led to his resignation"; "losing him is no great deprivation"」
deprivation

WordNet   license wordnet

「the act of losing someone or something; "everyone expected him to win so his loss was a shock"」

WordNet   license wordnet

「the experience of losing a loved one; "he sympathized on the loss of their grandfather"」

PrepTutorEJDIC   license prepejdic

「〈U〉(…を)『失うこと』,紛失《+『of』+『名』》 / 〈C〉(…の)『損害』,損失;損失額《+『of』+『名』》 / 〈U〉〈C〉(…に)『負けること』,(…の)敗北;失敗《+『of』+『名』》 / 〈U〉(状態・程度の)『減少』,低下 / 《複数形で》(戦場における)(人の)損害,此傷者数」

decline」

  [★]

  • n.
  • v.
  • 低下する、減退する
decreasedepressiondiminishdiminutiondown-regulatedown-regulationdownregulatedownregulationdropfalllosslowerloweringreducereduction

WordNet   license wordnet

「inflect for number, gender, case, etc., "in many languages, speakers decline nouns, pronouns, and adjectives"」

WordNet   license wordnet

「a condition inferior to an earlier condition; a gradual falling off from a better state」
declination

WordNet   license wordnet

「change toward something smaller or lower」
diminution

PrepTutorEJDIC   license prepejdic

「(穏やかに,礼儀正しく)…'を'『断る』,拒絶する,拒否する / 〈名詞・代名詞・形容詞〉'を'語形変化させる / 『断る』,辞退する / 《文》〈土地などが〉『下に傾く』;〈太陽・月が〉傾く / 《文》『衰える』,衰徴する / 『衰徴』,衰弱」

WordNet   license wordnet

「grow smaller; "Interest in the project waned"」
go down, wane

WordNet   license wordnet

「go down in value; "the stock market corrected"; "prices slumped"」
slump, correct

WordNet   license wordnet

「go down; "The roof declines here"」

reduction」

  [★]

  • n.
declinedecreasedepressiondiminishdiminutiondown-regulatedown-regulationdownregulatedownregulationdropfallhypoergylosslowerloweringparsimonyreduceretrenchment

WordNet   license wordnet

「any process in which electrons are added to an atom or ion (as by removing oxygen or adding hydrogen); always occurs accompanied by oxidation of the reducing agent」
reducing

WordNet   license wordnet

「the act of reducing complexity」
simplification

PrepTutorEJDIC   license prepejdic

「〈U〉〈C〉(…を)『減らすこと』,減少,縮小,格下げ,(…の)割り引き《+『in』+『名』》 / 〈C〉減少(縮小)した量;割引額 / 〈C〉縮図,縮写 / 〈U〉換算約分」




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