WordNet

used of flowers having more than the usual number of petals in crowded or overlapping arrangements; "double chrysanthemums have many rows of petals and are usually spherical or hemispherical"
increase twofold; "The population doubled within 50 years" (同)duplicate
a base hit on which the batter stops safely at second base; "he hit a double to deep centerfield" (同)two-base hit, two-bagger, two-baser
someone who closely resembles a famous person (especially an actor); "he could be Gingrichs double"; "shes the very image of her mother" (同)image, look-alike
a stand-in for movie stars to perform dangerous stunts; "his first job in Hollywood was as a double for Clark Gable" (同)stunt man, stunt woman
a quantity that is twice as great as another; "36 is the double of 18"
twice as great or many; "ate a double portion"; "the dose is doubled"; "a twofold increase" (同)doubled, twofold, two-fold
consisting of or involving two parts or components usually in pairs; "an egg with a double yolk"; "a double (binary) star"; "double doors"; "dual controls for pilot and copilot"; "duple (or double) time consists of two (or a multiple of two) beats to a measure" (同)dual, duple
having more than one decidedly dissimilar aspects or qualities; "a double (or dual) role for an actor"; "the office of a clergyman is twofold; public preaching and private influence"- R.W.Emerson; "every episode has its double and treble meaning"-Frederick Harrison (同)dual, twofold, two-fold, treble, threefold, three-fold
having two meanings with intent to deceive; "a sly double meaning"; "spoke with forked tongue" (同)forked
bridge: make a demand for (a card or suit)
do double duty; serve two purposes or have two functions; "She doubles as his wife and secretary"
downward and forward; "he was bent double with pain"
hit a two-base hit
large enough for two; "a double bed"; "a double room"
two together; "some people sleep better double"
for or pertaining to or composed of men or boys; "the male lead"; "the male population"
an animal that produces gametes (spermatozoa) that can fertilize female gametes (ova)
a person who belongs to the sex that cannot have babies (同)male person
characteristic of a man; "a deep male voice"; "manly sports" (同)manful, manlike, manly, virile
being the sex (of plant or animal) that produces gametes (spermatozoa) that perform the fertilizing function in generation; "a male infant"; "a male holly tree"
a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"
increase by a factor of two; "doubling with a computer took no time at all"
raising the stakes in a card game by a factor of 2; "I decided his double was a bluff" (同)double
informal terms for a mother (同)mama, mamma, mom, momma, mommy, mammy, mum, mummy

PrepTutorEJDIC

(数量・強さ・重さ・価値などが)『2倍の』,倍の / 『二重の』,二様の;複の,対の,2人用の / 表裏のある,二心ある / (意味が)二様にとれる,あいまいな / (花が)八重の,重弁の / 『2倍に』,2倍だけ(twice) / 二重に,二様に / 対をなして,二人いっしょに / 〈U〉『2倍』[の数量・価額など] / 〈C〉2倍のもの / 〈C〉よく似た人(物),生き写し / 〈C〉(映画の)代役 / 《複数形》《単数扱い》(テニスなどの)ダブルス / 〈C〉(獲物が追っ手を逃れるときなどの)逆走,急転回 / 〈C〉2塁打 / 〈C〉(ブリッジの点の)倍加 / 〈C〉(競馬・ドッグレースの)重勝式のかけ,複式 / …‘を'『2倍にする』 / …‘を'『二つ折りにする』 / …‘の'2倍の数(量)がある / 〈二役〉‘を'ひとりで演ずる / 〈船が〉〈岬〉‘を'回る / 『2倍になる』 / (…の役を)兼ねる《+『as』+『名』》 / (急に)取って返す,逆戻りする《+『back』》 / 二つ折りになる / (ブリッジで)相手のせり高を倍加する / 2塁打を打つ
『男性の』,男の;(動物が)雄の,(植物が)雄性の / 《名詞の前にのみ用いて》(機械・器具などが)雄の差し込み口のある / 『男性』;(動物の)雄,雄性植物
(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態
《M-》《話》おかあちゃん(mamma)

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1. 関節過剰可動性症候群 joint hypermobility syndrome
2. ダウン症：臨床的特徴および診断 down syndrome clinical features and diagnosis
3. カウデン症候群などのPTEN過誤腫症候群 pten hamartoma tumor syndrome including cowden syndrome
4. アンドロゲン受容体障害の診断および治療 diagnosis and treatment of disorders of the androgen receptor
5. Uncommon congenital adrenal hyperplasias

English Journal

Cardiometabolic biomarkers in chronic plaque psoriasis before and after etanercept treatment.

Puig L1, Strohal R, Fuiman J, Pedersen R, Szumski A, Koenig AS, Robertson D, Drexel H.Author information 1Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona , Barcelona , Spain .AbstractOBJECTIVE: To assess cardiometabolic biomarkers in patients with psoriasis before and after etanercept treatment.
The Journal of dermatological treatment.J Dermatolog Treat.2014 Dec;25(6):470-81. doi: 10.3109/09546634.2013.848260. Epub 2013 Nov 13.
OBJECTIVE: To assess cardiometabolic biomarkers in patients with psoriasis before and after etanercept treatment.METHODS: Patients with moderate-to-severe plaque psoriasis were randomized to etanercept 50 mg once or twice weekly, double-blinded. Cardiometabolic biomarkers were assessed at baseline
PMID 24219012

Chemerin reduces vascular nitric oxide/cGMP signalling in rat aorta: a link to vascular dysfunction in obesity?

Neves KB, Lobato NS1, Lopes RA2, Filgueira FP2, Zanotto CZ1, Oliveira AM3, Tostes RC2.Author information 1‡Department of Biological Sciences, Federal University of Goias, Jatai, GO, Brazil.2†Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil.3*Department of Physics and Chemistry, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.AbstractThe adipokine chemerin has been implicated in cardiovascular complications associated with obesity and the metabolic syndrome. Chemerin has direct effects on the vasculature, augmenting vascular responses to contractile stimuli. As NO/cGMP signalling plays a role in vascular dysfunction associated with obesity and the metabolic syndrome, we hypothesized that chemerin induces vascular dysfunction by decreasing NO/cGMP signalling. Aortic rings from male Wistar rats (10-12 weeks of age) were incubated with chemerin (0.5 or 5 ng/ml for 1 h) or vehicle and isometric tension was recorded. Vasorelaxation in response to ACh (acetylcholine), SNP (sodium nitroprusside) and BAY 412272 [an sGC (soluble guanylate cyclase) stimulator] were decreased in chemerin-treated vessels. The NOS (NO synthase) cofactor BH4 (tetrahydrobiopterin), an O2- (superoxide anion) scavenger (tiron) and a SOD (superoxide dismutase) mimetic (tempol) abolished the effects of chemerin on ACh-induced vasodilation. eNOS (endothelial NOS) phosphorylation, determined by Western blotting, was increased in chemerin-treated vessels; however, the enzyme was mainly in the monomeric form, with decreased eNOS dimer/monomer ratio. Chemerin decreased the mRNA levels of the rate-limiting enzyme for BH4 biosynthesis GTP cyclohydrolase I. Chemerin-incubated vessels displayed decreased NO production, along with increased ROS (reactive oxygen species) generation. These effects were abrogated by BH4, tempol and L-NAME (NG-nitro-L-arginine methyl ester). sGC protein expression and cGMP levels were decreased in chemerin-incubated vessels. These results demonstrate that chemerin reduces NO production, enhances NO breakdown and also decreases NO-dependent cGMP signalling, thereby reducing vascular relaxation. Potential mechanisms mediating the effects of chemerin in the vasculature include eNOS uncoupling, increased O2- generation and reduced GC activity.
Clinical science (London, England : 1979).Clin Sci (Lond).2014 Jul 1;127(2):111-22. doi: 10.1042/CS20130286.
The adipokine chemerin has been implicated in cardiovascular complications associated with obesity and the metabolic syndrome. Chemerin has direct effects on the vasculature, augmenting vascular responses to contractile stimuli. As NO/cGMP signalling plays a role in vascular dysfunction associated w
PMID 24498891

Randomised clinical trial: gluten may cause depression in subjects with non-coeliac gluten sensitivity - an exploratory clinical study.

Peters SL1, Biesiekierski JR, Yelland GW, Muir JG, Gibson PR.Author information 1Department of Gastroenterology, Central Clinical School, Monash University, The Alfred Hospital, Melbourne, Vic, Australia.AbstractBACKGROUND: Current evidence suggests that many patients with self-reported non-coeliac gluten sensitivity (NCGS) retain gastrointestinal symptoms on a gluten-free diet (GFD) but continue to restrict gluten as they report 'feeling better'.
Alimentary pharmacology & therapeutics.Aliment Pharmacol Ther.2014 May;39(10):1104-12. doi: 10.1111/apt.12730. Epub 2014 Apr 1.
BACKGROUND: Current evidence suggests that many patients with self-reported non-coeliac gluten sensitivity (NCGS) retain gastrointestinal symptoms on a gluten-free diet (GFD) but continue to restrict gluten as they report 'feeling better'.AIM: To investigate the notion that a major effect of gluten
PMID 24689456