二重鎖切断修復、二本鎖切断修復

WordNet

prevent completion; "stop the project"; "break off the negotiations" (同)break off, discontinue, stop
happen; "Report the news as it develops"; "These political movements recrudesce from time to time" (同)recrudesce, develop
become separated into pieces or fragments; "The figurine broke"; "The freshly baked loaf fell apart" (同)separate, split up, fall_apart, come apart
be broken in; "If the new teacher wont break, well add some stress"
crack; of the male voice in puberty; "his voice is breaking--he should no longer sing in the choir"
destroy the integrity of; usually by force; cause to separate into pieces or fragments; "He broke the glass plate"; "She broke the match"
diminish or discontinue abruptly; "The patients fever broke last night"
fall sharply; "stock prices broke"
render inoperable or ineffective; "You broke the alarm clock when you took it apart!"
weaken or destroy in spirit or body; "His resistance was broken"; "a man broken by the terrible experience of near-death"
vary or interrupt a uniformity or continuity; "The flat plain was broken by tall mesas"
(tennis) a score consisting of winning a game when your opponent was serving; "he was up two breaks in the second set" (同)break of serve
an escape from jail; "the breakout was carefully planned" (同)breakout, jailbreak, gaolbreak, prisonbreak, prison-breaking
an act of delaying or interrupting the continuity; "it was presented without commercial breaks"; "there was a gap in his account" (同)interruption, disruption, gap
a sudden dash; "he made a break for the open door"
the opening shot that scatters the balls in billiards or pool
an unexpected piece of good luck; "he finally got his big break" (同)good_luck, happy chance
an abrupt change in the tone or register of the voice (as at puberty or due to emotion); "then there was a break in her voice"
the occurrence of breaking; "the break in the dam threatened the valley"
interrupt a continued activity; "She had broken with the traditional patterns" (同)break away
break a piece from a whole; "break a branch from a tree" (同)break off, snap off
move away or escape suddenly; "The horses broke from the stable"; "Three inmates broke jail"; "Nobody can break out--this prison is high security" (同)break_out, break away
destroy the completeness of a set of related items; "The book dealer would not break the set" (同)break_up
force out or release suddenly and often violently something pent up; "break into tears"; "erupt in anger" (同)burst, erupt
ruin completely; "He busted my radio!" (同)bust
be released or become known; of news; "News of her death broke in the morning" (同)get_out, get_around
go to pieces; "The lawn mower finally broke"; "The gears wore out"; "The old chair finally fell apart completely" (同)wear, wear_out, bust, fall_apart
become punctured or penetrated; "The skin broke"
cause the failure or ruin of; "His peccadilloes finally broke his marriage"; "This play will either make or break the playwright"
cause to give up a habit; "She finally broke herself of smoking cigarettes"
change directions suddenly
change suddenly from one tone quality or register to another; "Her voice broke to a whisper when she started to talk about her children"
come forth or begin from a state of latency; "The first winter storm broke over New York"
come into being; "light broke over the horizon"; "Voices broke in the air"
come to an end; "The heat wave finally broke yesterday"
curl over and fall apart in surf or foam, of waves; "The surf broke"
emerge from the surface of a body of water; "The whales broke"
exchange for smaller units of money; "I had to break a $100 bill just to buy the candy"
find a flaw in; "break an alibi"; "break down a proof"
find the solution or key to; "break the code"
give up; "break cigarette smoking"
happen or take place; "Things have been breaking pretty well for us in the past few months"
interrupt the flow of current in; "break a circuit"
invalidate by judicial action; "The will was broken"
make a rupture in the ranks of the enemy or ones own by quitting or fleeing; "The ranks broke"
make the opening shot that scatters the balls
pierce or penetrate; "The blade broke her skin"
scatter or part; "The clouds broke after the heavy downpour"
separate from a clinch, in boxing; "The referee broke the boxers"
undergo breaking; "The simple vowels broke in many Germanic languages"
used of flowers having more than the usual number of petals in crowded or overlapping arrangements; "double chrysanthemums have many rows of petals and are usually spherical or hemispherical"
increase twofold; "The population doubled within 50 years" (同)duplicate
a base hit on which the batter stops safely at second base; "he hit a double to deep centerfield" (同)two-base hit, two-bagger, two-baser
someone who closely resembles a famous person (especially an actor); "he could be Gingrichs double"; "shes the very image of her mother" (同)image, look-alike
a stand-in for movie stars to perform dangerous stunts; "his first job in Hollywood was as a double for Clark Gable" (同)stunt man, stunt woman
a quantity that is twice as great as another; "36 is the double of 18"
twice as great or many; "ate a double portion"; "the dose is doubled"; "a twofold increase" (同)doubled, twofold, two-fold
consisting of or involving two parts or components usually in pairs; "an egg with a double yolk"; "a double (binary) star"; "double doors"; "dual controls for pilot and copilot"; "duple (or double) time consists of two (or a multiple of two) beats to a measure" (同)dual, duple
having more than one decidedly dissimilar aspects or qualities; "a double (or dual) role for an actor"; "the office of a clergyman is twofold; public preaching and private influence"- R.W.Emerson; "every episode has its double and treble meaning"-Frederick Harrison (同)dual, twofold, two-fold, treble, threefold, three-fold
having two meanings with intent to deceive; "a sly double meaning"; "spoke with forked tongue" (同)forked
bridge: make a demand for (a card or suit)
do double duty; serve two purposes or have two functions; "She doubles as his wife and secretary"
downward and forward; "he was bent double with pain"
hit a two-base hit
large enough for two; "a double bed"; "a double room"
two together; "some people sleep better double"
drive (a vessel) ashore
line consisting of a complex of fibers or filaments that are twisted together to form a thread or a rope or a cable
a pattern forming a unity within a larger structural whole; "he tried to pick up the strands of his former life"; "I could hear several melodic strands simultaneously"
a poetic term for a shore (as the area periodically covered and uncovered by the tides)
move, travel, or proceed toward some place; "He repaired to his cabin in the woods" (同)resort
restore by replacing a part or putting together what is torn or broken; "She repaired her TV set"; "Repair my shoes please" (同)mend, fix, bushel, doctor, furbish up, restore, touch_on
a formal way of referring to the condition of something; "the building was in good repair"
the act of putting something in working order again (同)fix, fixing, fixture, mend, mending, reparation
increase by a factor of two; "doubling with a computer took no time at all"
raising the stakes in a card game by a factor of 2; "I decided his double was a bluff" (同)double

PrepTutorEJDIC

…'を'『壊す』,割る,砕く;…'を'折る / …'を'擦りむく / …'を'『役に立たなくする』,壊す / (小さな物に)〈組になった物〉'を'分ける,ばらす,〈お金〉'を'くずす《+『名』+『into』+『名』》 / 〈垣・へいなど〉'を'破って出る / 〈法律・規則・約束など〉'を'『破る』,犯す / 〈均整・秩序・配列など〉'を'破る,くずす;〈持続しているもの〉'を'中止する,妨げる / 〈記録〉'を'破る,更新する / (…に)…'を'打ち明ける,知らせる《+『名』+『to』+『名』》 / …'を'破産させる,倒産させる / 〈気力・抵抗など〉'を'くじく;〈力・効果・強度〉'を'弱める / (…に)…‘の'位を下げる,…'を'降等させる《+『名』+『to』+『名』》 / 〈動物〉'を'ならす / 〈人〉‘の'(…の)癖を直す《+『名』〈人〉+『of』+『名』(do『ing』)》 / 〈暗号など〉'を'解読する;〈事件・問題など〉を解決する,解く / 《しばしば副詞[句]を伴って》『壊れる』,砕ける,割れる;破れる,破裂する / ぷっつりと切れる;中断する,途切れる;《米》仕事を中断する / はずれる,離れる,分離する《+『off』(『away』)》 / 故障する,壊れる,動かなくなる / 突然始まる;突然変化する / 夜が明ける / 〈健康・気力などが〉衰える,弱る;〈心が〉悲しみに打ちひしがれる / 〈株・価格などが〉急落する,暴落する / 壊れた箇所,裂け目,割れ目 / 中断,途切れ;不和,仲たがい / 休憩時間,小休止 / 逃亡計画,脱獄 / (…に向かっての)突進 / 急な変化,顕著な変化 / 夜明け / 《話》運,機会
(数量・強さ・重さ・価値などが)『2倍の』,倍の / 『二重の』,二様の;複の,対の,2人用の / 表裏のある,二心ある / (意味が)二様にとれる,あいまいな / (花が)八重の,重弁の / 『2倍に』,2倍だけ(twice) / 二重に,二様に / 対をなして,二人いっしょに / 〈U〉『2倍』[の数量・価額など] / 〈C〉2倍のもの / 〈C〉よく似た人(物),生き写し / 〈C〉(映画の)代役 / 《複数形》《単数扱い》(テニスなどの)ダブルス / 〈C〉(獲物が追っ手を逃れるときなどの)逆走,急転回 / 〈C〉2塁打 / 〈C〉(ブリッジの点の)倍加 / 〈C〉(競馬・ドッグレースの)重勝式のかけ,複式 / …‘を'『2倍にする』 / …‘を'『二つ折りにする』 / …‘の'2倍の数(量)がある / 〈二役〉‘を'ひとりで演ずる / 〈船が〉〈岬〉‘を'回る / 『2倍になる』 / (…の役を)兼ねる《+『as』+『名』》 / (急に)取って返す,逆戻りする《+『back』》 / 二つ折りになる / (ブリッジで)相手のせり高を倍加する / 2塁打を打つ
〈船〉‘を'座礁させる / 《受動態で》〈人〉‘を'置き去りにする,困った状態におく / 〈船が〉座礁する / 〈人が〉途方に暮れる,立ち往生する / 岸,浜
こ撚(よ)り(何本かより合わせて糸・なわなどにするその一本) / (より合わせた)糸,ひも;(頭髪の)房 / (真珠・ビーズなど)ひもに通したもの
…‘を'『修繕する』,修理する / …‘を'『償う』;…‘を'訂正する』 / …‘を'回復する / 修繕(修理)できる / 『修繕』,『修理』,修繕作業 / 〈U〉手入れ(修理)の状態
(大挙して)(…へ)行く(GO)《+『to』+『名』》

UpToDate Contents

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4. 毛細血管拡張性運動失調症 ataxia telangiectasia
5. 転移性大腸癌に対する全身化学療法：終了した臨床試験 systemic chemotherapy for metastatic colorectal cancer completed clinical trials

English Journal

Programmable Site-Specific Nucleases for Targeted Genome Engineering in Higher Eukaryotes.

Govindan G1, Ramalingam S1.
Journal of cellular physiology.J Cell Physiol.2016 Nov;231(11):2380-92. doi: 10.1002/jcp.25367. Epub 2016 Mar 15.
Recent advances in the targeted genome engineering enable molecular biologists to generate sequence specific modifications with greater efficiency and higher specificity in complex eukaryotic genomes. Programmable site-specific DNA cleavage reagents and cellular DNA repair mechanisms have made this
PMID 26945523

DNA-PK Deficiency in Alzheimer's Disease.

Kanungo J1.
Journal of neurology & neuromedicine.J Neurol Neuromedicine.2016 Sep;1(3):17-22.
Alzheimer's disease (AD) is characterized by neuronal death with an accumulaton of intra-cellular neurofibrillary tangles (NFT) and extracellular amyloid plaques. Reduced DNA repair ability has been reported in AD brains. In neurons, the predominant mechanism to repair double-strand DNA breaks (DSB)
PMID 27376156

Effect of mild temperature shift on poly(ADP-ribose) and γH2AX levels in cultured cells.

Yamashita S1, Tanaka M2, Sato T1, Ida C3, Ohta N1, Hamada T1, Uetsuki T1, Nishi Y1, Moss J4, Miwa M5.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2016 Aug 5;476(4):594-9. doi: 10.1016/j.bbrc.2016.06.001. Epub 2016 Jun 2.
Poly (ADP-ribose) (PAR) is rapidly synthesized by PAR polymerases (PARPs) upon activation by DNA single- and double-strand breaks. In this study, we examined the quantitative amount of PAR in HeLa cells cultured within the physiological temperatures below 41 °C for verification of the effect of sh
PMID 27262441

Japanese Journal

DNA二本鎖切断修復経路を最適化する時空間的制御機構

放射線生物研究 = Radiation biology research communications : 放射線生物研究会機関誌 53(2), 116-131, 2018-06
NAID 40021642264

Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites

PLoS Genetics 14(3), e1007277, 2018-03-28
NAID 120006459820

Histone Deacetylase Inhibitor Induced Radiation Sensitization Effects on Human Cancer Cells after Photon and Hadron Radiation Exposure

International journal of molecular sciences 19(2), 496, 2018-02
NAID 120006460182

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★リンクテーブル★

リンク元	「二本鎖切断修復」「二重鎖切断修復」
拡張検索	「double-strand break repair pathway」
関連記事	「break」「strand」「double」「double strand」「doubling」