WordNet

a complex consisting of an organic base in association with hydrogen chloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/29 17:15:13」(JST)

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Dorzolamide (trade name Trusopt) is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent, and acts by decreasing the production of aqueous humour.^[1] It is administered as a topical ophthalmic in the form of a 2% solution.^[2]

History

This drug, developed by Merck, was the first drug in human therapy (market introduction 1995) which resulted from structure-based drug design. It was developed to circumvent the systemic side effects of acetazolamide which has to be taken orally.^[2]

Uses

Dorzolamide hydrochloride is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.

Pharmacodynamics

It lowers IOP by about 20%.^[2]

Side effects

Ocular stinging, burning, itching and bitter taste.^[2] it causes shallowing of the anterior chamber and leads to transient myopia.

References

^ Dorzolamide at Drugs.com. Revised: 12/2011
^ ^a ^b ^c ^d KD Tripari MD. Essentials of Medical Pharmacology (5 ed.). Jaypee Brothers Medical Publishers(P) Ltd. p. 88. ISBN 81-8061-187-6.

UpToDate Contents

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1. 網膜色素変性症：治療 retinitis pigmentosa treatment
2. 原発性乳児緑内障 primary infantile glaucoma

English Journal

Fundus Autofluorescence and SD-OCT Document Rapid Progression in Autosomal Dominant Vitreoretinochoroidopathy (ADVIRC) Associated with a c.256G > A Mutation in BEST1.

Kellner S1,2, Stöhr H3, Fiebig B3,4, Weinitz S1,2, Farmand G1, Kellner U1,2, Weber BH3.
Ophthalmic genetics.Ophthalmic Genet.2016 Jun;37(2):201-8. doi: 10.3109/13816810.2015.1033556. Epub 2016 Jan 15.
PURPOSE: To report the variability of clinical findings, rapid concentric progression, and successful treatment of macular edema in autosomal dominant vitreoretinochoroidopathy (ADVIRC) associated with a heterozygous c.256G > A missense mutation in the bestrophin-1 (BEST1) gene.METHODS: Three
PMID 26771239

Angle closure caused by a plateau-like iris associated with an enlarged Soemmering's ring: a case report.

Kitamura F1, Inoue T2, Kuroda U1, Tanihara H1.
BMC ophthalmology.BMC Ophthalmol.2016 May 4;16(1):49. doi: 10.1186/s12886-016-0226-0.
BACKGROUND: This study evaluated the anterior ocular segment in a pseudophakic eye with angle closure due to a plateau-like iris associated with Soemmering's ring, using ultrasound biomicroscopy (UBM) and anterior segment optical coherence tomography (AS-OCT).CASE PRESENTATION: A 60-year-old woman w
PMID 27145815

Efficacy of Bimatoprost Plus Timolol Fixed Combination in Open Angle Glaucoma Patients Previously Treated with Dorzolamide Plus Timolol Fixed Combination.

Sacchi M1, Specchia C2,3, Williams SE4, Villani E1, Nucci P1.
Current eye research.Curr Eye Res.2016 Apr 26:1-5. [Epub ahead of print]
PURPOSE: To evaluate the efficacy and safety of bimatoprost plus timolol fixed combination (BTFC) in patients with primary open angle glaucoma (POAG) previously treated with dorzolamide plus timolol fixed combination (DTFC).MATERIALS AND METHODS: Retrospective, medical records review study. Medical
PMID 27115319

Japanese Journal

プロスタグランジン関連点眼液併用下でのβ遮断点眼液あるいは炭酸脱水酵素阻害点眼液から1%ドルソラミド塩酸塩・0.5%チモロールマレイン酸塩配合点眼液への変更時の眼圧下降効果と安全性

井上賢治,富田剛司
あたらしい眼科 31(1), 115-118, 2014-01
NAID 40019958111

2剤併用を配合薬1剤に変更した場合の1年6カ月の眼圧下降効果

小林茂樹,小林守治
あたらしい眼科 = Journal of the eye 30(7), 1011-1013, 2013-07-30
NAID 10031189386

2剤併用を配合薬1剤に変更した場合の1年6ヵ月の眼圧下降効果 (第23回日本緑内障学会)

小林茂樹,小林守治
あたらしい眼科 30(7), 1011-1013, 2013-07
NAID 40019753322

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★リンクテーブル★

リンク元	「ドルゾラミド」
関連記事	「dorzolamide」「hydrochloride」

「ドルゾラミド」

Dorzolamide
Systematic (IUPAC) name
	(4S,6S)-2-ethylamino-4-methyl-5,5-dioxo-; 5λ6,7-dithiabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide
Clinical data
Trade names	Trusopt
AHFS/Drugs.com	monograph
MedlinePlus	a602022
Pregnancy; category	US: C (Risk not ruled out); ;
Legal status	US: ℞-only;
Routes of; administration	Topical (eye drops)
Pharmacokinetic data
Protein binding	~33%
Biological half-life	4 months
Identifiers
CAS Number	130693-82-2 120279-96-1
ATC code	S01EC03
PubChem	CID: 5284549
IUPHAR/BPS	6810
DrugBank	DB00869
ChemSpider	4447604
UNII	9JDX055TW1
KEGG	D07871
ChEBI	CHEBI:4702
ChEMBL	CHEMBL218490
Chemical data
Formula	C10H16N2O4S3
Molecular mass	324.443 g/mol
	SMILES CCNC1CC(C)S(=O)(=O)c2sc(cc12)S(=O)(=O)N ;
	InChI InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 ; Key:IAVUPMFITXYVAF-XPUUQOCRSA-N ;
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