BMC biology.BMC Biol.2016 Aug 1;14:63. doi: 10.1186/s12915-016-0285-y.
BACKGROUND: Gene regulatory networks (GRNs) underlie developmental patterning and morphogenetic processes, and changes in the interactions within the underlying GRNs are a major driver of evolutionary processes. In order to make meaningful comparisons that can provide significant insights into the e
Anterior-Posterior Patterning of Definitive Endoderm Generated from Human Embryonic Stem Cells Depends on the Differential Signaling of Retinoic Acid, Wnt-, and BMP-Signaling.
Stem cells (Dayton, Ohio).Stem Cells.2016 Jun 14. doi: 10.1002/stem.2428. [Epub ahead of print]
As known from model organisms, such as frog, fish, mouse, and chicken, the anterior-posterior patterning of the definitive endoderm (DE) into distinct domains is controlled by a variety of signaling interactions between the DE and its surrounding mesoderm. This includes Wnt/FGFs and BMPs in the post
Skeletal patterning in the sea urchin embryo requires coordinated signaling between the pattern-dictating ectoderm and the skeletogenic primary mesenchyme cells (PMCs); recent studies have begun to uncover the molecular basis for this process. Using an unbiased RNA-Seq-based screen, we have previous
Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Jones CM, Kuehn MR, Hogan BL, Smith JC, Wright CV. Department of Cell Biology, Vanderbilt University Medical School, Nashville, TN 37232-2175, ...