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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/26 18:58:05」(JST)

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  • Safety of an Oral Fixed Combination of Netupitant and Palonosetron (NEPA): Pooled Data From the Phase II/III Clinical Program.
  • Aapro M1, Hesketh PJ2, Jordan K3, Gralla RJ4, Rossi G5, Rizzi G5, Palmas M5.
  • The oncologist.Oncologist.2016 Apr;21(4):494-502. doi: 10.1634/theoncologist.2015-0301. Epub 2016 Mar 21.
  • BACKGROUND: Standard prophylaxis for chemotherapy-induced nausea and vomiting (CINV) with highly emetogenic and anthracycline-cyclophosphamide-based chemotherapy includes a 5-hydroxytryptamine-3 receptor antagonist, a neurokinin-1 receptor antagonist (NK1RA), and corticosteroid therapy. NEPA is a fi
  • PMID 27000465
  • The prospective IQ-CSRC trial: A prototype early clinical proarrhythmia assessment investigation for replacing the ICH E14 thorough QTc (TQT) study.
  • Cavero I1, Holzgrefe H2, Clements M3.
  • Journal of pharmacological and toxicological methods.J Pharmacol Toxicol Methods.2016 Mar 9;80:1-8. doi: 10.1016/j.vascn.2016.02.181. [Epub ahead of print]
  • INTRODUCTION: Early clinical Phase I ECG investigations designed to replace the currently applied thorough QT (TQT) study are reviewed to examine how they could complement and verify the conclusions of nonclinical investigations and, in particular, the Comprehensive in vitro Proarrhythmia Assay (CiP
  • PMID 26903171
  • Implications of the IQ-CSRC Prospective Study: Time to Revise ICH E14.
  • Darpo B1, Garnett C, Keirns J, Stockbridge N.
  • Drug safety.Drug Saf.2015 Sep;38(9):773-80. doi: 10.1007/s40264-015-0325-5.
  • Exposure-response (ER) analysis has evolved as an important tool to evaluate the effect of a drug on cardiac repolarization, as reflected in the QTc interval. It has been suggested that careful electrocardiogram (ECG) evaluation in 'first-in-human' studies using ER analysis could replace or serve as
  • PMID 26162419


  • A Practical and Direct Comparison of Intrinsic Metabolic Clearance of Several Non-CYP Enzyme Substrates in Freshly Isolated and Cryopreserved Hepatocytes
  • AKABANE Takafumi,GERST Nicolas,NARITOMI Yoichi,MASTERS Jeffrey N.,TAMURA Kouichi
  • Drug Metabolism and Pharmacokinetics 27(2), 181-191, 2012
  • … However, the number of compounds with >20% CLint reduction decreased to 3 on comparing average of CLint values including un-matched donors (dolasetron: −27%, naltorexone: −32%, and phthalazine: −48%; …
  • NAID 130004463242
  • Carbonyl reduction of naltrexone and dolasetron by oxidoreductases isolated from human liver cytosol
  • Dolasetron decreases postoperative nausea and vomiting after breast surgery


Dolasetron (trade name Anzemet) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center ...
Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations.