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  • Antiarrhythmic Effects of Combining Dofetilide and Ranolazine in a Model of Acutely Induced Atrial Fibrillation in Horses.
  • Carstensen H1, Kjær L, Haugaard MM, Flethøj M, Hesselkilde EZ, Kanters JK, Pehrson S, Buhl R, Jespersen T.
  • Journal of cardiovascular pharmacology.J Cardiovasc Pharmacol.2017 Oct 25. doi: 10.1097/FJC.0000000000000541. [Epub ahead of print]
  • PMID 29068807
  • AuthorsIbrahim MA1, Bhimji SS.
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  • PMID 29083831
  • In silico assessment of the effects of various compounds in MEA/hiPSC-CM assays: Modeling and numerical simulations.
  • Abbate E, Boulakia M, Coudière Y, Gerbeau JF, Zitoun P, Zemzemi N.
  • Journal of pharmacological and toxicological methods.J Pharmacol Toxicol Methods.2017 Oct 21. pii: S1056-8719(16)30165-4. doi: 10.1016/j.vascn.2017.10.005. [Epub ahead of print]
  • We propose a mathematical approach for the analysis of drugs effects on the electrical activity of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) based on multi-electrode array (MEA) experiments. Our goal is to produce an in silico tool able to simulate drugs action in MEA/hi
  • PMID 29066291



Effects of Dofetilide on I kr Dofetilide blocks I Kr in all myocardial tissues with high potency (50% effective concentration [EC 50] in the nanomolar range). Block is voltage dependent and most prominent at depolarized potentials. 1 3 4 It does not occur in resting muscle but rather develops on depolarization. ...
View and buy high purity Dofetilide from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents ... Biological Activity Selective potassium channel blocker. Blocks K V 11.1 (hERG) channels ...