出典: meddic


sodium valproatevalproatevalproic acid


  • Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
  • Zhou R1, Lu Y1, Han Y1, Li X1, Lou H1, Zhu L1, Zhen X2, Duan S3.
  • Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2015 Dec 3;63:110-8. doi: 10.1016/j.pnpbp.2015.06.007. Epub 2015 Jun 16.
  • Mutations in cathepsin D (CTSD), an aspartic protease in the endosomal-lysosomal system, underlie congenital neuronal ceroid-lipofuscinosis (cNCL, also known as CLN10), a devastating neurodegenerative disease. CLN10 patients die within the first few days of life, and in the few patients who live int
  • PMID 26092248
  • Lithium is associated with decrease in all-cause and suicide mortality in high-risk bipolar patients: A nationwide registry-based prospective cohort study.
  • Toffol E1, Hätönen T2, Tanskanen A3, Lönnqvist J4, Wahlbeck K5, Joffe G6, Tiihonen J3, Haukka J7, Partonen T8.
  • Journal of affective disorders.J Affect Disord.2015 Sep 1;183:159-65. doi: 10.1016/j.jad.2015.04.055. Epub 2015 May 8.
  • BACKGROUND: Mortality rates, in particular due to suicide, are especially high in bipolar patients. This nationwide, registry-based study analyses the associations of medication use with hospitalization due to attempted suicides, deaths from suicide, and overall mortality across different psychotrop
  • PMID 26005778
  • Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate.
  • Wang SY1, Ren M2, Jiang HZ1, Wang J1, Jiang HQ1, Yin X1, Qi Y1, Wang XD1, Dong GT1, Wang TH1, Yang YQ1, Feng HL3.
  • Neuroscience.Neuroscience.2015 Aug 20;301:276-88. doi: 10.1016/j.neuroscience.2015.06.002. Epub 2015 Jun 8.
  • Amyotrophic lateral sclerosis (ALS) is an idiopathic and lethal neurodegenerative disease that currently has no effective treatment. A recent study found that the Notch signaling pathway was up-regulated in a TAR DNA-binding protein-43 (TDP-43) Drosophila model of ALS. Notch signaling acts as a mast
  • PMID 26067594


  • Successful Initiation of Combined Therapy with Valproate Sodium Injection and Divalproex Sodium Extended-release Tablets in the Epilepsy Monitoring Unit
  • Epilepsia : journal of the International League against Epilepsy 46(6), 949-951, 2005-06-01
  • NAID 10017069356
  • Extended-release Divalproex in Child and Adolescent Outpatients with Epilepsy
  • Epilepsia : journal of the International League against Epilepsy 46(3), 440-443, 2005-03-01
  • NAID 10016479329
  • Divalproex-ER pharmacokinetics in older children and adolescents


Valproate semisodium (INN) or divalproex sodium (USAN) consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. It is used in the United Kingdom, Canada, and United States for the ...
Learn about the prescription medication Depakote (Divalproex Sodium Delayed Release Tablets), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling.



先読みsodium valproate

sodium valproate」

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