distribution of drugs

出典: meddic

specific agents

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  • Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats.
  • Westerhout J, Ploeger B, Smeets J, Danhof M, de Lange EC.SourceDepartment of Pharmacology, Leiden/Amsterdam Center for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
  • The AAPS journal.AAPS J.2012 Sep;14(3):543-53. Epub 2012 May 17.
  • One of the major challenges in the development of central nervous system (CNS)-targeted drugs is predicting CNS exposure in human from preclinical data. In this study, we present a methodology to investigate brain disposition in rats using a physiologically based modeling approach aiming at improvin
  • PMID 22588644
  • ADME of Biologics-What Have We Learned from Small Molecules?
  • Prueksaritanont T, Tang C.SourceDepartment of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, WP 75A-203, Merck Sharp and Dohme Corp., West Point, Pennsylvania, 19486, USA, thomayant_prueksaritanont@merck.com.
  • The AAPS journal.AAPS J.2012 Sep;14(3):410-9. Epub 2012 Apr 7.
  • Thorough characterization and in-depth understanding of absorption, distribution, metabolism, and elimination (ADME) properties of a drug candidate have been well recognized as an important element in small molecule (SM) drug discovery and development. This has been the area of focus for drug metabo
  • PMID 22484625


  • ベキ正規分布に基づく階層仮説を用いた生物学的同等性の評価
  • 古川 泰伸,後藤 昌司
  • 計算機統計学 25(2), 87-104, 2013-06-17
  • 後発医薬品や投薬方法の改良による薬剤については,ヒトに対する「生物学的同等性(BioEqui-valence,以下BE)」の評価のみで申請,および承認を受けることが可能である.日本では,厚生省(現厚生労働省,1997)に従い標準製剤と試験製剤の母集団平均の差の信頼区間に基づいてBEが評価されている.他方,上述の評価過程には,諸種の統計的問題が内包され,BEの特徴を理論的かつ方法論的に体系だてて評価 …
  • NAID 110009625174
  • Impact of P-glycoprotein and breast cancer resistance protein on the brain distribution of antiepileptic drugs in knockout mouse models.
  • Nakanishi Haruka,Yonezawa Atsushi,Matsubara Kazuo,Yano Ikuko
  • European journal of
  • … Refractory epilepsy is reportedly associated with an overexpression of ATP-binding cassette transporters such as P-glycoprotein (Pgp) and breast cancer resistance protein (Bcrp). … In this study, we examined the contribution of Pgp and Bcrp to the brain distribution of 12 antiepileptic drugs (AEDs) in Mdr1a/1b(-/-) and Mdr1a/1b(-/-)/Bcrp(-/-) mice within a therapeutic concentration range. …
  • NAID 120005289852
  • Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21)
  • Tamai Ikumi
  • Biopharmaceutics and Drug Disposition 34(1), 29-44, 2013-01-00
  • … The carnitine/organic cation transporter (OCTN) family consists of three transporter isoforms, i.e. OCTN1 (SLC22A4) and OCTN2 (SLC22A5) in humans and animals and Octn3 (Slc22a21) in mice. … These transporters are physiologically essential to maintain appropriate systemic and tissue concentrations of carnitine by regulating its membrane transport during intestinal absorption, tissue distribution and renal reabsorption. …
  • NAID 120004997007


Drug enters the body by absorption. Inside the body, drugs move in the blood to different parts of the body. Distribution of drugs can be defined as: “The process by which a drug reversibly leaves the blood stream and enters the ...
Distribution of drugs [SH4:p10] Perfusion and drug distribution Highly perfused tissues receive a disproportionately large amount of drug --> Acts as reservoir When plasma concentration drops below the concentration in these tissues


Figure 1: Drug Metabolism PathwaysDistribution of Drugs - Pharmacokinetic Distribution Of DrugsFont size:Volume of distribution019 Distribution of drugs




  • n.
  • 分配、配布、配給、配分。流通、販売。(郵便の)区分。(統計)分布。(薬)分布(証券)売り抜け。(ミサの)聖品の分餐

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「the spatial or geographic property of being scattered about over a range, area, or volume; "worldwide in distribution"; "the distribution of nerve fibers"; "in complementary distribution"」

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「the act of distributing or spreading or apportioning」

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「the commercial activity of transporting and selling goods from a producer to a consumer」

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「(statistics) an arrangement of values of a variable showing their observed or theoretical frequency of occurrence」
statistical distribution

PrepTutorEJDIC   license prepejdic

「〈U〉(…への)『配分』,『分配』,配布,配達《+『to』+『名』》 / 〈U〉分布;分布区域 / 〈C〉配分されたもの,配給品 / 〈U〉(商品の)流通[組織,機構]」



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「《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)」




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「use recreational drugs」
do drugs

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「administer a drug to; "They drugged the kidnapped tourist"」

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「a substance that is used as a medicine or narcotic」

PrepTutorEJDIC   license prepejdic

「『薬』,薬品,薬剤 / 『麻薬』,麻酔剤 / 〈人〉‘に'薬(特に麻酔剤)を与える / 〈飲食物〉‘に'(麻酔薬・毒薬などの)薬を混ぜる」



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「OLD French古[代]フランス語」