diphenylhydantoin

出典: meddic

ジフェニルヒダントイン

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「an anticonvulsant drug (trade name Dilantin) used to treat epilepsy and that is not a sedative」
phenytoin, Dilantin

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/08/22 03:39:13」(JST)

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英文文献

  • A comparison of four antiepileptic drugs in status epilepticus: experience from India.
  • Misra UK1, Kalita J1.
  • The International journal of neuroscience.Int J Neurosci.2016 Nov;126(11):1013-9. doi: 10.3109/00207454.2015.1095743. Epub 2015 Oct 20.
  • PURPOSE: We report the efficacy and safety of lorazepam (LOR), phenytoin (PHT), valproate (VPA) and levetiracetam (LEV) as first and second choice antiepileptic drug (AED) in status epilepticus (SE) and their combinations in preventing refractory SE.MATERIALS AND METHODS: The results of our two earl
  • PMID 26456955
  • Concentration of antiepileptic drugs in persons with epilepsy: a comparative study in serum and saliva.
  • Dwivedi R1, Singh M1, Kaleekal T2, Gupta YK2, Tripathi M1.
  • The International journal of neuroscience.Int J Neurosci.2016 Nov;126(11):972-8. doi: 10.3109/00207454.2015.1088848. Epub 2015 Oct 6.
  • AIM OF THE STUDY: The monitoring of antiepileptic drugs (AEDs) in clinical setting is important for measuring the efficacy of drugs and their safety and in personalizing drug therapy. We investigated the levels of AED, carbamazepine (CBZ), phenytoin (PHT) and phenobarbital (PHB), to understand their
  • PMID 26441313
  • A novel path to chronic proprioceptive disability with oxaliplatin: Distortion of sensory encoding.
  • Vincent JA1, Wieczerzak KB1, Gabriel HM1, Nardelli P2, Rich MM1, Cope TC3.
  • Neurobiology of disease.Neurobiol Dis.2016 Nov;95:54-65. doi: 10.1016/j.nbd.2016.07.004. Epub 2016 Jul 7.
  • Persistent neurotoxic side effects of oxaliplatin (OX) chemotherapy, including sensory ataxia, limit the efficacy of treatment and significantly diminish patient quality of life. The common explanation for neurotoxicity is neuropathy, however the degree of neuropathy varies greatly among patients an
  • PMID 27397106

和文文献

  • One Trial of the Development of Image Analyzing Method of Cardiomyocytes Derived from ES Cells as Alternative Method of Cardiotoxicity Test Based on an Electrocardiogram -Analysis of Chronotropic and the Inotropic Action-
  • Kawai Sumiko,Takagi Yasuhiro,Shioya Kyoko,Kurosawa Tsutomu
  • Alternatives to Animal Testing and Experimentation 17(1), 9-12, 2012
  • … The pulsatile frequency and intensity of the beating cardiomyocyte were inhibited after exposure to Diphenylhydantoin (DPH). …
  • NAID 130004679887
  • Diphenylhydantoin-Induced Severe yet Reversible Anemia during Pregnancy
  • Sugaya Akinori,Nakamagoe Kiyotaka,Okoshi Yasushi,Obata-Yasuoka Mana,Tamaoka Akira
  • Internal Medicine 49(22), 2515-2518, 2010
  • Diphenylhydantoin (DPH) therapy, often used in treating epileptic seizures, can cause anemia in some patients. …
  • NAID 130000413387
  • Evaluation of brain and whole-body pharmacokinetics of ^<11>C-labeled diphenylhydantoin in rats by means of planar positron imaging system
  • HASEGAWA Yukinori,KANAI Yasukazu,HASEGAWA Shinji,OKAMOTO Takashi,MATSUI Tamiko,SHIMOSEGAWA Eku,KURACHI Yoshihisa,HATAZAWA Jun
  • Annals of nuclear medicine 22(4), 301-307, 2008-05-01
  • NAID 10021281082

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★リンクテーブル★
リンク元フェニトイン」「DPH
拡張検索amino(diphenylhydantoin) valeric acid

フェニトイン」

  [★]

phenytoin PHT
phenytoinum
ジフェニルヒダントイン diphenylhydantoin DPH
アレビアチンフェニトインNヒダントールホストインDilantin複合アレビアチン配合
抗痙攣薬不整脈治療薬
  • Ib群

構造

作用機序

  • 不活性化状態のNaチャネルに結合 (SPC.186)

薬理作用

抗てんかん薬

  • てんかん発作波の出現は抑制しない(けいれん閾値は変化しない)
  • 異常発射の焦点から周辺への伝播を押さえる

抗不整脈薬

作用はリドカインに似るが、作用は弱い。

動態

  • 肝臓

適応

欠神発作では増悪
  • QT延長に伴う心室性不整脈、ジギタリス不整脈

注意

  • 血中濃度に注意する
血中濃度を幻覚にコントロールすべき薬物:テオフィリンフェニトインジゴキシン

禁忌

副作用

  • 歯肉増殖症、緩急振戦、運動失調、複視、多毛症、皮疹、大球性貧血

相互作用

DPH」

  [★] フェニトインジフェニルヒダントイン, diphenylhydantoin


amino(diphenylhydantoin) valeric acid」

  [★] アミノジフェニルヒダントイン吉草酸




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