Spectroscopic detection of etoposide binding to chromatin components: The role of histone proteins.
Chamani E1, Rabbani-Chadegani A2, Zahraei Z3.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2014 Dec 10;133:292-9. doi: 10.1016/j.saa.2014.05.068. Epub 2014 Jun 5.
Chromatin has been introduced as a main target for most anticancer drugs. Etoposide is known as a topoisomerase II inhibitor, but its effect on chromatin components is unknown. This report, for the first time, describes the effect of etoposide on DNA, histones and DNA-histones complex in the structu
DNA topoisomerase II plays an essential role in animal spermiogenesis, where changes of chromatin structure are connected with appearance of transient DNA breaks. Such topo II activity can be curtailed by inhibitors such as etoposide and suramine. The aim of the present study was to investigate, for
BACKGROUND: Lysine methylation is the most versatile covalent posttranslational modification (PTM) found in histones and non-histone proteins. Over the past decade a number of methyllysine-specific readers have been discovered and their interactions with histone tails have been structurally and bioc
dinucleosome Definition from Wiktionary, the free dictionary Jump to: navigation, search English [edit] Noun [edit] dinucleosome (plural dinucleosomes) (biochemistry, genetics) A short complex of nucleosomes that is formed as the ...
Definition of Dinucleosome with photos and pictures, translations, sample usage, and additional links for more information. ... ¹ Source: wiktionary.com Dinucleosome Pictures Click the following link to bring up a new window with an ...